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1.
背景 复发性流产(RSA)发病率呈逐年上升趋势,严重影响妇女身心健康,目前现代医学对RSA的病因和发病机制尚未完全明确。目的 了解RSA病因的分布情况,以及流产孕周与流产次数和RSA病因之间的关系。方法 选取2018年在新疆医科大学第二附属医院确诊为RSA的患者198例,收集患者的一般资料包括年龄、自然流产次数、流产孕周,并筛查患者的病因:染色体异常、生殖道解剖结构异常、内分泌系统异常、生殖道感染、自身免疫异常等,并对这些资料进行回顾性分析。根据患者的流产孕周,分为早期RSA组(<12周)(155例)和晚期RSA组(≥12周)(43例);根据流产次数分为2次组(123例)和≥3次组(75例)。分析RSA患者各病因所占比例,以及RSA病因在不同流产孕周组和不同流产次数组间的差异。结果 198例RSA患者,染色体异常9例(4.55%),生殖道解剖结构异常11例(5.56%),内分泌系统异常36例(18.18%),生殖道感染14例(7.07%),自身免疫异常30例(15.15%),不明病因98例(49.49%)。晚期RSA组患者生殖道解剖结构异常发生率大于早期RSA组,不明病因发生率低于早期RSA组(P<0.05);早期RSA组与晚期RSA组患者染色体异常、内分泌系统异常、生殖道感染、自身免疫异常发生率比较,差异均无统计学意义(P>0.05)。流产次数2次组和流产次数≥3次组患者染色体异常、生殖道解剖结构异常、内分泌系统异常、生殖道感染、自身免疫异常、不明病因发生率比较,差异均无统计学意义(P>0.05)。结论 导致RSA的病因有多种,包括染色体异常、生殖道解剖结构异常、内分泌系统异常、生殖道感染、自身免疫异常及不明病因等多种因素,其中不明病因的RSA占多数;生殖道解剖结构异常对妊娠晚期的影响大于妊娠早期。 相似文献
2.
《Anais brasileiros de dermatologia》2020,95(1):98-101
Pachydermoperiostosis (PDP) or primary hypertrophic osteoarthropathy (PHO) is a rare hereditary disease characterized by digital clubbing, pachydermia, and periostosis. Its pathogenesis is uncertain and the diagnosis is based on clinical and radiological data. A complete form of the syndrome is reported in a male patient with disease onset in adolescence, with compatible clinical and radiological findings, presenting the three cardinal findings as well as other associated manifestations, such as hyperhidrosis and acne. 相似文献
3.
目的:根据广义生物遗传与变异信息理论方程推导的2个生物相似度常数P_(g1)=69%,P_(g2)=61%及生物亲缘关系判别函数P_g=1/lnN_d对中国产8种甘草进行理论分类及亲缘关系判别,并提出了生物的理论品种概念。方法:基于8种甘草所含有的59种代表性黄酮类化合物,计算各种甘草之间的共有成分率及变异成分率,采用2个常数及判别函数确定各自的特征序列,根据特征序列进行分类。结果:8种甘草可以分为3类,且8种甘草之间具有紧密的亲缘关系。根据59种特征黄酮类化学成分,可以给出比经典分类结果更精细确定的分类结果,可将严格的理论分类定义为理论品种。结论:广义生物遗传与变异信息理论方程结合植物的多种化学成分,可以对生物进行绝对的理论分类及亲缘关系判别,实现基于数理原理,而不是经验知识的准确科学生物分类,提出了判别生物亲缘关系的理论标准,为确定具有相似功效的中药材提供严谨的科学依据。 相似文献
4.
5.
Uğur Şaylı Elif Çiğdem Altunok Melih Güven Budak Akman Jnev Biros Ayşe Şaylı 《Acta orthopaedica et traumatologica turcica》2018,52(3):167-173
Objective
This survey was designed to evaluate the prevalence estimations of HV, bunionette, hammertoe as well as their relations to shoe wearing and also familial tendency, in Turkey.Material and Methods
Two thousand six hundred sixty two volunteers (1615 females and 1047 males) with a mean age of 34.15 ± 14.23 (range; 18 to 96) years were asked to answer the predetermined questionnaire between January and June, 2016. Hallux valgus, hammertoe and bunionette images were provided as references and every adult participant without any known forefoot problems or past forefoot surgery history was asked to rate his/her foot and to respond the questions about family history and shoe wearing habits. Responses were statistically analyzed.Results
The prevalence estimations of hallux valgus, bunionette and hammertoe were calculated as 54.3%, 13.8% and 8.9% and positive family history rates were 53.2%, 61.2% and 56.1%, respectively. All three deformities were more common in females than in males (p < 0.001). Nonetheless the older age group reported significantly higher prevalence rates for only HV (p < 0.001). Likewise, among the three deformities, females reported a higher rate of positive family history only in HV compared to men (p < 0.001). Constricting shoe wear was found to affect HV incidence in women (p < 0.001) and bunionette incidence in both sexes (p < 0.01).Conclusion
This study concludes that forefoot deformities are common with high familial tendency. Hence it is worthwhile to work on molecular genetics and this may enable the anticipation of forthcoming deformities in order to take early action in prevention, in nearly the half of the population. 相似文献6.
作为青少年特发性脊柱侧凸(AIS)发病的研究热点,遗传机制探索经过候选基因及全基因组关联研究(GWAS)时代后,初步鉴定一些相关基因.综述AIS相关基因研究现状,并初步构建AIS基因关系网络图.在NCBI-Pubmed数据库和Web of Science中检索“adolescent idiopathic scoliosis”和“gene”,分类归纳基因.用String-db构建基因关系图.共识别35个AIS相关基因,将其按病因学假设可分为结缔组织、神经系统活性物质、褪黑素合成与代谢、青春期与生长及功能未知.大部分基因呈现网络关系,其中IL6、ESR1、ESR2、VDR、TGFB1、IGF1可能是AIS遗传机制的重要基因.3个GWAS位点有两个在网络之外,提示新通路.AIS易感基因研究尚初步,需要深入研究,解析机制,鉴定新网络. 相似文献
7.
Nikolai Krementsov 《Medical history》2015,59(1):6-31
This essay examines the ‘infiltration’ of eugenics into Russian medical discourse during the formation of the eugenics movement in western Europe and North America in 1900–17. It describes the efforts of two Russian physicians, the bacteriologist and hygienist Nikolai Gamaleia (1859–1949) and the psychiatrist Tikhon Iudin (1879–1949), to introduce eugenics to the Russian medical community, analysing in detail what attracted these representatives of two different medical specialties to eugenic ideas, ideals, and policies advocated by their western colleagues. On the basis of a close examination of the similarities and differences in Gamaleia’s and Iudin’s attitudes to eugenics, the essay argues that lack of cohesiveness gave the early eugenics movement a unique strength. The loose mix of widely varying ideas, ideals, methods, policies, activities and proposals covered by the umbrella of eugenics offered to a variety of educated professionals in Russia and elsewhere the possibility of choosing, adopting and adapting particular elements to their own national, professional, institutional and disciplinary contexts, interests and agendas. 相似文献
8.
Anna Grauers Aina Danielsson Magnus Karlsson Acke Ohlin Paul Gerdhem 《European spine journal》2013,22(11):2421-2426
Purpose
To study family history in relation to curve severity, gender, age at diagnosis and treatment in idiopathic scoliosis.Methods
A self-assessment questionnaire on family history of scoliosis was administered to 1,463 untreated, brace or surgically treated idiopathic scoliosis patients.Results
Out of the 1,463 patients, 51 % had one or more relatives with scoliosis. There was no significant difference between females and males, nor between juvenile and adolescent study participants in this respect (p = 0.939 and 0.110, respectively). There was a significant difference in maximum curve size between patients with one or more relatives with scoliosis (median 35°, interquartile range 25) and patients without any relative with scoliosis (median 32°, interquartile range 23) (p = 0.022). When stratifying patients according to treatment (observation, brace treatment or surgery), we found that it was more common to have a relative with scoliosis among the treated patients (p = 0.011). The OR for being treated was 1.32 (95 % CI 1.06–1.64) when the patient had a relative with scoliosis, compared to not having.Conclusions
Larger curve sizes were found in patients with a family history of scoliosis than in the ones without. No relation between family history and gender or between family history and age at onset of idiopathic scoliosis was found. Although the presence of a family history of scoliosis may not be a strong prognostic risk factor, it indicates that these patients are at higher risk of developing a more severe curve. 相似文献9.
10.
Enrique Pimentel 《Acta diabetologica》1979,16(3):193-201
Summary Human DM consists of a heterogeneous group of metabolic disorders which have as a common denominator diminished carbohydrate
tolerance. Genetic factors are probably important in the etiology of almost all cases of DM, excluding perhaps only those
produced by pancreatectomy. However, the precise mechanisms of expression of the genetic defects related to DM have been elucidated
only in a few cases whereas the majority, especially those of MOD, should probably be considered multifactorial in origin
(complex interplay between polygenic and environmental factors). Several less frequent forms of DM can be inherited in a typical
Mendelian way, either alone (e.g. probably MODY) or associated with certain well defined genetic diseases (where carbohydrate
intolerance is a frequent component of the clinical picture). JOD should most probably be attributed to the action of some
as yet unidentified environmental factors, perhaps viruses, in subjects with a particular genetic predisposition. This predisposition
seems to be closely associated with certain HLA antigens, particularly those of the D series. The mechanisms responsible for
this association remain a matter of controversy. Autoimmune phenomena appear to be important in the pathogenesis of JOD. The
ability of certain viruses to induce DM has been clearly demonstrated in a few experimental systems by infecting genetically
susceptible animals. Under such conditions, DM is produced by a destruction of the pancreatic islets. On the other hand, there
is as yet no conclusive evidence concerning the possibility that exogenous and/or endogenous viruses may play a role in the
etiology of human DM. Patients with certain chromosome abnormalities are prone to develop DM. On the other hand, there are
no available data concerning a possible effect of DM on the incidence of chromosome abnormalities in patients with the disease
or in the embryos and fetuses of diabetic mothers. The possibility of congenital transmission of a predisposition to DM (which
might possibly be inherited thereafter) through the action of some unknown epigenetic mechanisms has been suggested on the
basis of limited clinical and experimental observations. However, further information is necessary in order to clarify the
validity of such a curious possibility. 相似文献