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1.
Summary

Further experience with maintenance depot treatment of 199 schizophrenic patients over a 42-month period has confirmed an earlier report by the same investigators of the effectiveness of flupenthixol decanoate as an antipsychotic agent and its value in maintaining schizophrenics in the community. Ten percent of patients required re-admission to hospital for treatment of psychotic relapse during this 3\-year period. Over the whole period only 28% of patients showed extrapyramidal side-effects, in most cases trivial in degree, so that the routine prophylactic prescribing of anti-parkinsonism drugs with flupenthixol decanoate would appear to be unjustified. Depression was noted in 15 % of patients (10 % severe; 5 % moderate), an incidence which, though no higher than that encountered in fluphenazine-treated patients, was disappointingly high for a drug used, in lower dosage, specifically for the treatment of neurotic depression. Other side-effects noted were transient hypomania and anergia, each in 7% of the group. There was no unequivocal evidence of toxicity. The mean dose required by the first 78 patients (31.97 to 33.46?mg./3 weeks) did not vary very significantly over a 2-year treatment period.  相似文献   
2.
杜辉  管强 《中国当代医药》2012,(30):79+81-79,81
目的观察多潘立酮联合氟哌噻吨美利曲辛片治疗原发性胆汁反流性胃炎(PBRG)患者的疗效。方法将78例PBRG患者随机分为两组,多潘立酮联合氟哌噻吨美利曲辛片组(观察组)和单用多潘立酮组(对照组),疗程均为4周,观察药物疗效。结果治疗后,观察组的总有效率(82.5%)显著高于对照组(55.3%)。结论在PBRG的治疗过程中,适当采用氟哌噻吨美利曲辛与促动力药联用,可以提高治愈率,对于常规内科治疗效果不佳的PBRG患者,可以考虑联合应用氟哌噻吨美利曲辛。  相似文献   
3.
美利曲辛合剂治疗伴有情绪障碍偏头痛和丛集性头痛   总被引:3,自引:0,他引:3  
目的探索治疗伴有抑郁和/或焦虑症状的偏头痛和丛集性头痛的有效方法.方法将伴有抑郁和/或焦虑症状的偏头痛患者154例和丛集性头痛患者28例随机分为两组,即美利曲辛合剂(黛力新)及头痛发作时加用散立痛组(治疗组,偏头痛组最终完成68例,丛集性头痛组最终完成11例)和头痛发作时单用散立痛组(对照组,偏头痛组最终完成59例,丛集性头痛组最终完成9例),进行随机单盲对照研究,同时用汉密尔顿抑郁量表评分(HAMD)和汉密尔顿焦虑量表评分(HAMA)对其抑郁和/或焦虑状况进行治疗前及治疗后(第2,4,6周)的评估.结果偏头痛治疗组不但可以明显减轻患者所伴有的抑郁和/或焦虑症状(第4,6周均P<0.01),还可以显著减少头痛发作次数(第4周P<0.05,第6周P<0.01)、缩短头痛发作持续时间(第2,4,6周均P<0.01);而丛集性头痛治疗组虽然能显著减少丛集性头痛患者的HAMD评分(第4周P<0.05,第6周P<0.01)及HAMA评分(第4,6周均P<0.01),但是却不能减少患者的丛集期头痛发作次数和头痛发作持续时间(第2,4,6周均P>0.05).结论对于伴有抑郁和/或焦虑状态的偏头痛患者,美利曲辛合剂具有一定的防治作用;而对于伴有抑郁和/或焦虑状态的丛集性头痛患者,美利曲辛合剂没有防治作用.  相似文献   
4.
On the basis of results obtained from passive avoidance studies, we have argued that the neuropeptide vasopressin could act on arousal, rather than memory processes in rats (Sahgal et al. 1982). In this report, we examine the effects of substances that are known to increase (d-amphetamine) or decrease (chlordiazepoxide) behavioural arousal, and compare the data with those obtained after vasopressin or oxytocin treatment. All four substances yielded broadly similar bimodal results (although the oxytocin data failed to reach significance). We argue for an arousal interpretation which suggests that performance and arousal are related in an inverted-U manner. The data also indicate that care must be taken in selecting appropriate statistical tests.  相似文献   
5.
Low doses of the uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) induce locomotor stimulation in mice, whereas higher doses are associated with ataxia, stereotyped behaviors and catalepsy. We investigated the role of dopamine receptors and presynaptic dopamine neurons in the locomotor effects of dizocilpine. For comparison, we studied several other drugs that induce locomotor stimulation in mice. Pretreatment of male mice with haloperidol (0.1 mg/kg, i.p.) completely prevented the stimulation of normally coordinated locomotion induced by a non-intoxicating dose of dizocilpine (0.1 mg/kg, i.p.); haloperidol also attenuated the locomotor stimulation produced by phencyclidine (PCP, 1 and 2 mg/kg, i.p.), d-amphetamine (2 and 5 mg/kg, i.p.) and diazepam (0.5 mg/kg, i.p.). Haloperidol (doses up to 2.5 mg/kg) did not attenuate the ataxia and decreased locomotion induced by higher doses of dizocilpine (1 and 2 mg/kg). The active cis isomer of flupenthixol (0.5 mg/kg, i.p.), an antagonist of both D1 and D2 dopamine receptors, also diminished the stimulant actions of all of the test drugs, whereas its inactive trans form did not. The selective D1 antagonist R(±)-SCH 23390 (0.1 mg/kg) and the selective D2 antagonist raclopride (1 mg/kg) had little effect on the stimulatory effect of dizocilpine, although they did reduce the stimulation produced by PCP, d-amphetamine and diazepam. However, pretreatment with a combination of R(±)-SCH 23390 and raclopride completely prevented dizocilpine-induced locomotor stimulation. Pretreatment with α-methyl-p-tyrosine (AMPT, 50 and 250 mg/kg), an inhibitor of tyrosine hydroxylase, or with 6-hydroxydopamine (6-OH-DA, 50 μg, i.c.v.), a neurotoxin that destroys brain dopaminergic and noradrenergic neurons, did not attenuate the locomotor stimulation induced by dizocilpine, although these treatments did reduce the stimulant effects of d-amphetamine. In AMPT or 6-OH-DA pretreated mice, haloperidol (0.125 mg/kg) prevented the stimulatory effect of dizocilpine. These results support a role for dopamine receptors in the stimulation of normally coordinated locomotion by dizocilpine. However, the locomotor stimulant effect of dizocilpine, unlike that of d-amphetamine, can be expressed in the presence of D1 or D2 dopamine receptor blockade and does not appear to be dependent on intact presynaptic mechanisms.  相似文献   
6.
A double-blind withdrawal trial in 41 chronic schizophrenic outpatients was carried out during 6 months. Depot neuroleptics (fluphenazine decanoate or flupenthixol decanoate) were compared with placebo to evaluate clinical and neurological effects during continued therapy and during withdrawal. The drugs were significantly more effective than placebo in preventing relapse and rehospitalization. In the placebo group 62% relapsed compared to 27% in the drug group. There was a weak and nonsignificant tendency to a higher relapse frequency in the flupenthixol group compared to the fluphenazine group. After withdrawal for 6 months, plasma levels for fluphenazine were detectable. Plasma levels for flupenthixol were not detectable after 9 weeks of withdrawal. The differences in the plasma levels may possibly explain the difference in relapse rate between the two depot neuroleptics. Furthermore, it was found that the patients who relapsed during fluphenazine treatment had a significantly lower plasma level of the drug than patients who did not relapse during treatment. The results from this study provide some information on the therapeutic levels of fluphenazine and flupenthixol in schizophrenic patients.  相似文献   
7.
目的 了解氟哌噻吨美利曲辛联合常规药物与单用常规药物治疗肠易激综合征(IBS)疗效的差异.方法 检索中国期刊全文数据库、中国维普全文数据库、PubMed外文期刊数据库,检出氟哌噻吨美利曲辛联合其他常规药物(匹维溴铵及马来酸曲美布汀)与单用常规药物治疗IBS的研究进行比较分析,并在此基础上进行异质性检验和合并效应量的估计.结果 共检出12项疗程为4~12周的氟哌噻吨美利曲辛联合其他常规药物治疗IBS的临床试验,其中6项研究提示氟哌噻吨美利曲辛联合匹维溴铵与单用匹维溴铵治疗比较,异质性检验x2=1.90,自由度(df)=5,P=0.86,I2=0,固定效应模型的合并比值比(OR)=7.92,95% CI(4.85,12.95),提示联合优于单药治疗;另6项研究提示氟哌噻吨美利曲辛联合马来酸曲美布汀与单用马来酸曲美布汀治疗比较,异质性检验X2=5.60,df=5,P=0.35,I2=10.6%,固定效应模型OR=5.91,95% CI(4.06,8.61),提示联合优于单药治疗.合并该12项研究提示氟哌噻吨美利曲辛联合其他常规药物与单用常规药物治疗比较,异质性检验x2=8.40,df=11,P=0.68,I2=0,固定效应模型OR=6.63,95% CI(4.92,8.93).结论 氟哌噻吨美利曲辛联合其他药物治疗IBS的疗效优于单用其他常规药物,但仍需进一步高质量的研究验证.  相似文献   
8.
徐杲  华娴  徐希  龚菲 《医学研究杂志》2016,45(1):138-140,162
目的 研究氟哌噻吨美利曲辛联合质子泵抑制剂(PPI)治疗伴焦虑抑郁症状的非糜烂性胃食管反流病(NERD)的临床疗效。方法 将2012年1月~2014年9月笔者医院消化内科治疗的伴焦虑抑郁症状的NERD患者90例,采用数字表法随机分为联合组和对照组,各45例。对照组采用PPI埃索美拉唑治疗(每日早晨空腹口服),同时辅以心理疏导,治疗组在此基础上给予氟哌噻吨美利曲辛片(早餐、午餐后各1次),疗程均为8周。比较分析两组的临床疗效、焦虑抑郁及睡眠质量的改善情况、不良反应及复发情况。结果 联合组总有效率84.4%,显著高于对照组总有效率66.7%(P>0.05);治疗后,两组HAMD、HAMA评分均有明显改善,联合组HAMD、HAMA、PSGI评分显著低于对照组(P<0.05);联合组的复发率为8.9%,显著低于对照组24.4%(P<0.05);两组治疗期间均无严重不良反应。结论 在PPI常规治疗的基础上,联合氟哌噻吨美利曲辛治疗伴焦虑抑郁的NERD患者的可改善躯体不适症状,缓解焦虑抑郁等负性情绪及睡眠状况,降低复发。  相似文献   
9.
目的观察氟哌噻吨美利曲辛联合常规消化道药物治疗难治性功能性肠病的临床疗效。方法选择符合罗马标准Ⅲ的难治性功能性肠病患者60例,给予常规性治疗(如解痉剂、促动力药、益生菌等)联合氟哌噻吨美利曲辛方案,比较患者治疗前后临床症状、抑郁焦虑状态和生活质量评分。结果60例患者完成6周随访,治疗总有效率为96.6%,总的症状严重度分值[(3.78±1.6)分VS(1.98±0.78)分]明显降低(P〈0.01),单项症状严重程度及发作频率评分均明显减少(P〈0.05)。抑郁评分[(62.68±5.94)VS(47.7±16.06)分,P〈0.01]和焦虑评分[(61.35±6.86)vs(46.57±14.36)分,P〈0.01]均显著下降。结论氟哌噻吨美利曲辛联合常规药物治疗难治性功能性肠病可以明显改善患者的肠道症状,控制抑郁情绪,显著提高生活质量。  相似文献   
10.
目的观察氟哌噻吨美利曲辛治疗非小细胞肺癌(NSCLC)患者合并抑郁状态的临床效果。方法选择NSCLC合并抑郁状态患者76例,随机分为对照组和氟哌噻吨美利曲辛组,各38例,两组均给予NP方案化疗。化疗当日,对照组于早餐后半小时口服维生素C0.2g(2片);氟哌噻吨美利曲辛组于早餐后半小时口服氟哌噻吨美利曲辛(每片含氟哌噻吨0.5mg,美利曲辛10mg)2片。分别于治疗前及治疗第21、42天应用Zung抑郁自评量表(SDS)、中国癌症患者化学生物治疗生活质量量表(QLQ-CCC)、卡氏功能状态量表(KPS)评定患者抑郁状态及生活质量。结果治疗前两组SDS、QLQ-CCC、KPS评分差异无统计学意义,具有可比性(P〉0.05)。治疗第21、42天,氟哌噻吨美利曲辛组与对照组相比,SDS评分均明显降低(P〈0.01);治疗第42天,QLQ-CCC各项评分及KPS评分明显升高(P〈0.05)。结论氟哌噻吨美利曲辛可显著改善NSCLC患者的抑郁状态,提高患者的生活质量。  相似文献   
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