全文获取类型
收费全文 | 5002篇 |
免费 | 448篇 |
国内免费 | 135篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 167篇 |
妇产科学 | 57篇 |
基础医学 | 572篇 |
口腔科学 | 112篇 |
临床医学 | 291篇 |
内科学 | 399篇 |
皮肤病学 | 58篇 |
神经病学 | 2087篇 |
特种医学 | 247篇 |
外科学 | 398篇 |
综合类 | 287篇 |
预防医学 | 79篇 |
眼科学 | 461篇 |
药学 | 147篇 |
1篇 | |
中国医学 | 115篇 |
肿瘤学 | 65篇 |
出版年
2023年 | 100篇 |
2022年 | 119篇 |
2021年 | 221篇 |
2020年 | 232篇 |
2019年 | 186篇 |
2018年 | 218篇 |
2017年 | 197篇 |
2016年 | 181篇 |
2015年 | 175篇 |
2014年 | 283篇 |
2013年 | 301篇 |
2012年 | 208篇 |
2011年 | 232篇 |
2010年 | 208篇 |
2009年 | 204篇 |
2008年 | 222篇 |
2007年 | 221篇 |
2006年 | 211篇 |
2005年 | 161篇 |
2004年 | 149篇 |
2003年 | 147篇 |
2002年 | 132篇 |
2001年 | 114篇 |
2000年 | 77篇 |
1999年 | 75篇 |
1998年 | 75篇 |
1997年 | 74篇 |
1996年 | 67篇 |
1995年 | 62篇 |
1994年 | 78篇 |
1993年 | 66篇 |
1992年 | 53篇 |
1991年 | 62篇 |
1990年 | 36篇 |
1989年 | 45篇 |
1988年 | 41篇 |
1987年 | 36篇 |
1986年 | 29篇 |
1985年 | 36篇 |
1984年 | 49篇 |
1983年 | 19篇 |
1982年 | 39篇 |
1981年 | 33篇 |
1980年 | 27篇 |
1979年 | 24篇 |
1978年 | 16篇 |
1977年 | 15篇 |
1976年 | 10篇 |
1975年 | 7篇 |
1974年 | 3篇 |
排序方式: 共有5585条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
杨茹莱 《中国儿童保健杂志》2022,30(7):697-701
原发性免疫缺陷病(PID)及脊髓性肌萎缩症(SMA)均是由基因突变引起的能严重影响儿童健康甚至导致死亡的遗传性出生缺陷,早期发现和及时诊断治疗是影响预后的关键,新生儿筛查是目前实现早期诊断和干预的有效手段。近年来部分国家和地区已将SMA和PID中最为严重的重症联合免疫缺陷病(SCID)和最常见的B细胞缺乏症X连锁无丙种球蛋白血症(XLA)纳入新生儿筛查范围。浙江省在国内首次开展对SCID、XLA和SMA三种遗传性疾病的新生儿早期联合筛查实践,极大地提高了筛查效率,使出生缺陷三级预防关口前移,有助于显著改善患者的预后、提高生活质量、降低死亡率。 相似文献
5.
Imre W.K. Kouw Bart B.L. Groen Joey S.J. Smeets Irene Fleur Kramer Janneau M.X. van Kranenburg Rachél Nilwik Jan A.P. Geurts René H.M. ten Broeke Martijn Poeze Luc J.C. van Loon Lex B. Verdijk 《Journal of the American Medical Directors Association》2019,20(1):35-42
Objectives
Short successive periods of skeletal muscle disuse have been suggested to substantially contribute to the observed loss of skeletal muscle mass over the life span. Hospitalization of older individuals due to acute illness, injury, or major surgery generally results in a mean hospital stay of 5 to 7 days, during which the level of physical activity is strongly reduced. We hypothesized that hospitalization following elective total hip arthroplasty is accompanied by substantial leg muscle atrophy in older men and women.Design and participants
Twenty-six older patients (75 ± 1 years) undergoing elective total hip arthroplasty participated in this observational study.Measurements
On hospital admission and on the day of discharge, computed tomographic (CT) scans were performed to assess muscle cross-sectional area (CSA) of both legs. During surgery and on the day of hospital discharge, a skeletal muscle biopsy was taken from the m. vastus lateralis of the operated leg to assess muscle fiber type–specific CSA.Results
An average of 5.6 ± 0.3 days of hospitalization resulted in a significant decline in quadriceps (?3.4% ± 1.0%) and thigh muscle CSA (?4.2% ± 1.1%) in the nonoperated leg (P < .05). Edema resulted in a 10.3% ± 1.7% increase in leg CSA in the operated leg (P < .05). At hospital admission, muscle fiber CSA was smaller in the type II vs type I fibers (3326 ± 253 μm2 vs 4075 ± 279 μm2, respectively; P < .05). During hospitalization, type I and II muscle fiber CSA tended to increase, likely due to edema in the operated leg (P = .10).Conclusions
Six days of hospitalization following elective total hip arthroplasty leads to substantial leg muscle atrophy in older patients. Effective intervention strategies are warranted to prevent the loss of muscle mass induced by short periods of muscle disuse during hospitalization. 相似文献6.
7.
8.
M.-D.-M. Amador F. Muratet E. Teyssou S. Boillée S. Millecamps 《Revue neurologique》2021,177(5):524-535
Due to novel gene therapy opportunities, genetic screening is no longer restricted to familial cases of ALS (FALS) cases but also aplies to the sporadic populations (SALS). Screening of four main genes (C9orf72, SOD1, TARDBP and FUS) identified the causes in 15% of Amyotrophic Lateral Sclerosis (ALS) patients (two third of the familial cases and 8% of the sporadic ones) but their respective contribution to ALS phenotype varies according the age of disease onset. The genetic overlap between ALS and other diseases is expanding and includes frontotemporal dementia, Paget's Disease of Bone, myopathy for adult cases, HSP and CMT for young cases highlighing the importance of retrieving the exhaustive familial history for each indivdual with ALS. Incomplete disease penetrance, diversity of the possible phenotypes, as well as the lack of confidence concerning the pathogenicity of most identified variants and/or possible oligogenic inheritance are burdens of ALS genetic counseling to be delivered to patients and at risk individuals. The multitude of rare ALS genetic causes identifed seems to converge to similar cellular pathways leading to inapropriate response to stress emphacising new potential therapeutic options for the disease. 相似文献
9.
Brandon Ginley Kuang-Yu Jen Seung Seok Han Luís Rodrigues Sanjay Jain Agnes B. Fogo Jonathan Zuckerman Vighnesh Walavalkar Jeffrey C. Miecznikowski Yumeng Wen Felicia Yen Donghwan Yun Kyung Chul Moon Avi Rosenberg Chirag Parikh Pinaki Sarder 《Journal of the American Society of Nephrology : JASN》2021,32(4):837