Relationship between gut microbiota composition and sensitization to inhaled allergens

BackgroundAn imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens.MethodsThe study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Blood samples were analyzed for levels of antigen-specific IgE against Japanese cedar pollen (JCP) and house dust (HD1). Fecal samples were analyzed for bacterial 16S rRNA (ribosomal ribonucleic acid) using next generation sequencing. The percent composition of gut microbes was compared between patients sensitized and unsensitized group for JCP and HD1 to determine whether the rate of sensitization to inhaled antigens associates with specific bacterial orders composing the gut microbiota.ResultsIn participants aged 20–49 years, the percent composition of Bacteroidales was significantly higher among participants sensitized to JCP than in those unsensitized. The percent composition of Lactobacillales was significantly higher in participants unsensitized to HD group than in those sensitized to that antigen. In addition, participants with low Bacteroidales and high Bifidobacteriales or Lactobacillales has low sensitization rates to HD compared with high Bacteroidales and low Bifidobacteriales or Lactobacillales.ConclusionsThe presence of bacteria of order Lactobacillales, Bifidobacteriales, and Bacteroidales in the gut microbiota may affect sensitization to inhaled allergens.     

评估丹尼斯克乳双歧杆菌Bi07及嗜酸乳杆菌NCFM对人体肠道消化系统微生态环境改善功效的研究

目的评估丹尼斯克乳双歧杆菌Bi07及嗜酸乳杆菌NCFM对人体肠道消化系统微生态环境改善效果。方法将符合要求的400名25～45岁志愿者根据男：女=1：1的比例随机分为安慰剂组、益生菌产品组2个组。所有400名志愿者,分别在试验第一天至最后一天服用对应产品,每天2次,分别于上午10点和下午4点服用,每次100g,持续3周。结果可有效改善人体肠道消化系统微生态环境,志愿者体内双歧杆菌、乳杆菌活菌数显著增加（P〈0．01）,产气荚膜杆菌活菌数显著减少（P〈0．01）。结论连续服用丹尼斯克益生菌产品21d,每天200g,对人体肠道消化系统微生态环境的改善具有显著效果。