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1.
目的:观察阿奇霉素序贯治疗联合中药喜炎平注射液治疗小儿支原体肺炎的临床效果。方法:参照《诸福棠实用儿科学》的诊断标准选取支气管肺炎患儿56例,随机分为治疗组和对照组。治疗组给予阿奇霉素联合喜炎平静滴治疗,对照组给予常规剂量阿奇霉素静滴治疗,观察两组患儿咳嗽、气喘、发热消失时间和出现不良反应的情况。结果:治疗组临床疗效优于对照组。结论:阿奇霉素序贯治疗联合喜炎平注射液治疗小儿支原体肺炎疗效肯定,缩短了疗程,减少了副作用的发生,在临床上值得推广。  相似文献
2.
希舒美针剂治疗儿童肺炎支原体肺炎疗效观察   总被引:1,自引:0,他引:1  
目的 观察希舒美针剂治疗肺炎支原体肺炎的临床疗效.方法 将44例肺炎支原体肺炎住院患儿分为2组,分别用希舒美针剂(阿奇霉素,辉瑞制药)和国产阿奇霉素治疗,观察比较2组的临床症状、体征的改善情况.结果 希舒美组25例,1周后治愈17例,显效2例,好转6例,有效率(有效为治愈+显效)76.00%(19/25).对照组19例,治愈5例,显效9例,好转4例,无变化1例,有效率73.68%(14/19).2组对肺炎支原体肺炎治疗均有效,2组有效率比较差异无统计学意义(x2=0.03,P>0.05).但比较2组1周治愈率(x2=7.50,P<0.05)、退热时间(t=34.05.P<0.05)和啰音消失时间(t=2.39,P<0.05),希舒美组均优于对照组,差异均有统计学意义(P均<0.05).结论 希舒美针剂治疗肺炎支原体肺炎疗效好,在改善临床症状上具有一定优越性.
Abstract:
Objective To observe the effect Azithromycin injection in the treatment of mycoplasma pneumoniae pneumonia ( MPP) in children. Methods Forty-four children of mycoplasma pneumoniae pneumonia were randomly divided into two groups, the Azithromycin group ( treat by Azithromycin, made by Pfizer) and the control group (treat by domestic Azithromycin) respectively. Improvement in symptoms and signs between the two groups were observed and compared. Results There were 25 cases in the Azithromycin group, of which,after a week, 17 cases cured,2 cases got better significantly and 6 cases got better. The effective ratio was 76. 00% ( 19/25 ). There were 19 cases in the control group, of which 5 cases cured, 9 cases got better significantly ,4 cases got better and 1 case no change. The effective ratio was 73. 68% (14/19). There was no statistical significance in the effective ratio between the two groups ( x2 = 0. 03, P > 0. 05). However, the Azithromycin group was superior to the control group both in the one week cure rate (t = 7.50,P< 0.05) and on defervescence time (t = 34. 05, P < 0. 05 ) and rales disappearance (t = 2. 39, P < 0. 05 ). Conclusion Azithromycin injection is more effective than domestic Azithromycin in the treatment of mycoplasma pneumoniae pneumonia,especially in the aspect of improving symptoms.  相似文献
3.
哮喘小鼠肺组织STAT5、STAT6表达及阿奇霉素的影响   总被引:1,自引:0,他引:1  
罗莉  李婷  曹贵文 《中国实验诊断学》2010,14(10):1529-1531
目的观察阿奇霉素(AZM)对哮喘小鼠信号转导和转录激活因子5、6(STAT5、STAT6)的影响。方法 BALB/c小鼠24只随机分为三组,A组(哮喘模型组)、B组(阿奇霉素治疗组)、C组(正常对照组)。其中A、B组小鼠于第0、13天分别给予卵清蛋白(OVA)20μg和氢氧化铝1 mg的混悬液致敏,于第21-30天每天给予雾化吸入2%OVA建立哮喘模型,B组于15-30天给予阿奇霉素100 mg/kg/d腹腔注射,C组以0.9%生理盐水代替OVA致敏和激发。所有动物于31天处死,制备肺组织石蜡切片,应用免疫组化方法检测支气管肺组织STAT5、STAT6的表达水平。结果哮喘模型组STAT5、STAT6蛋白表达分别为(23.25±3.28)和(26.11±3.95)明显高于正常对照组(2.33±0.78)和(2.78±0.32)(P〈0.01),阿奇霉素治疗组STAT5、STAT6蛋白表达分别为(10.83±1.96)和(11.32±2.03)明显低于哮喘组(P〈0.01)。结论 STAT5S、TAT6与哮喘发病相关,阿奇霉素可通过下调STAT5、STAT6的表达抑制气道炎症。  相似文献
4.
Azithromycin-induced torsade de pointes   总被引:1,自引:0,他引:1  
Although erythromycin frequently induces long QT interval and torsade de pointes, the newer drug, azithromycin, has rarely been reported to be associated with torsade de pointes. We report here the occurrence of a significant typical QT prolongation within a few hours after taking azithromycin which lead to torsade de pointes.  相似文献
5.
目的:观察山莨菪碱在消除阿奇霉素所致胃肠道不良反应方面的效果并总结护理要点。方法:149例应用阿奇霉素静脉滴注过程中出现胃肠道不良反应的门诊患者随机分为试验组、对照组,试验组给予山莨菪碱治疗,对照组按常规方法处理,比较两组患者胃肠道不良反应的缓解情况。结果:山莨菪碱能迅速缓解阿奇霉素所致胃肠道不良反应,5min内,总有效率达97.4%,而对照组5min内的总有效率仅2.7%;15min时,实验组所有患者症状完全缓解,对照组30min后仍有45.2%的患者症状无缓解。结论:山莨菪碱能迅速、有效消除阿奇霉素所致的胃肠道不良反应。  相似文献
6.
吴文蓉  张淑华 《华西医学》1997,12(2):139-148
本研究的目的在于评价国产阿奇霉素的体内,外抗菌活性并与进口阿奇霉素及同类药罗红霉素与红霉素进行比较。结果表明,用琼脂二倍稀释法,阿奇霉素对临床分离的707株致病菌的体外抗菌谱与抗菌作用国产品与进口品相仿,阿奇霉素对呼吸道常见致病菌中的革兰氏阳性球菌具有强抗菌活性,对金葡菌,溶血性链球菌,肺炎链球菌,草绿色链球菌,奈瑟要球菌,嗜血流感力等MIC≤0.06mg/L,与罗红霉素,红霉素相似或稍强。革兰氏  相似文献
7.
The antimicrobial activity of azithromycin (AZM) was evaluated againstLegionella species using an experimental model of legionellosis. The minimum inhibitory concentration90s (MIC90s) of AZM against 35 standard strains (0.25 mg/L) and 22 Japanese clinical isolates ofLegionella pneumophila (0.063 mg/L) were lower than those of erythromycin (EM) and almost equal to those of clarithromycin and roxythromycin. Using14C-labeled antibiotic, AZM and EM were observed concentrated inside human polymorphonuclear leukocytes (PMN) with intracellular/extracellular concentration ratios of AZM and EM at 120 minutes after dosing of 27.3 and 22.2, respectively. AZM inhibited the growth ofL. pneumophila (80-045 strain) from cultured guinea pig alveolar macrophages, even when the extracellular AZM was washed out on day 2 of culture. However, the addition of identical concentrations of EM failed to produce a similar inhibition. Pharmacokinetic studies of AZM tissue distribution in guinea pigs infected withL. pneumophila 80-045 revealed high drug concentrations in the lung and liver and a longer half-life in these organs compared with those in plasma. Treatment of guinea pigs with experimentally-induced legionellosis with oral AZM (10 mg/kg/day for 2 days) was more effective than EM treatment (10 mg/kg/day for 4 days) or a placebo, and resulted in a significant improvement in the survival rate. Our results suggest that AZM is a promising new drug for the treatment of legionellosis using a short-term dosing regimen.  相似文献
8.
Recently, it was reported that amoxicillin-clavulanate has slightly higher activity than amoxicillin against Helicobacter pylori. In this study, we evaluated the in-vitro antibacterial activity of β-lactamase inhibitors against H. pylori. We investigated the susceptibility of 30 H. pylori strains to β-lactamase inhibitors, including clavulanate, sulbactam, and tazobactam. In short-term bactericidal studies, a clinical isolate of H. pylori NU27 was exposed to 1 × minimum inhibitory concentration (MIC) of the β-lactamase inhibitors, amoxicillin, clarithromycin, and amoxicillin-clavulanate for 3 and 6 h. The MICs90 for these β-lactamase inhibitors were 2, 4, and 2 mg/l, respectively. The short-term bactericidal studies showed that these β-lactamase inhibitors decreased viable counts of H. pylori during 6-h exposure at 1 × MIC. Our results suggest that β-lactamase inhibitors have in-vitro antibacterial activity against H. pylori. Amoxicillin and clavulanate used in combination resulted in increased antibacterial activity. Received: July 1, 1999 / Accepted: September 13, 1999  相似文献
9.
A patient on disopyramide developed disopyramide toxicity when treated concurrently with azithromycin. Evidence of toxicity included an elevated serum disopyramide level and ventricular tachycardia requiring cardioversion. The azalide antibiotic presumably inhibited dealkylation of disopyramide to its major metabolite, mono-N-dealkyldisopyramide. Physicians should avoid using azithromycin in patients on disopyramide. If this drug combination is unavoidable, disopyramide levels must be closely monitored.  相似文献
10.
Administration of oral azithromycin, in addition to previously well-tolerated long-term amiodarone therapy, was associated with a marked prolongation of QT interval and increased QT dispersion, both substrates for life-threatening ventricular tachyarrhythmia and torsades de pointes. This is a report of QT prolongation and increased QT dispersion associated with the use of azithromycin. The report assumes an added significance, in view of widespread empirical use of this antibiotic for the treatment of lower respiratory infections and belief of its safety in patients with cardiac diseases. Based on the authors' experience, they would like to emphasize that the combination of azithromycin with other drugs known to prolong QT or causing torsades de pointes be used with caution until the question of the proarrhythmic effect of azithromycin is resolved by further studies.  相似文献
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