三级甲等综合医院护士情域能力及影响因素研究

目的调查贵州省三级甲等综合医院临床护士情域能力现状并探讨影响因素,为采取干预措施提高情域能力提供参考。方法采用护士情域能力评价量表对贵州省9个州市45个临床科室的1 823名临床护士进行调查。结果临床护士情域能力评价量表总得分、专业信念感知能力、专业内涵领悟能力、专业价值评价能力、专业价值内化能力得分分别为108.61±22.53、21.71±4.82、30.34±6.43、26.48±5.51、30.08±6.72。护士年龄、岗位、最高学历、是否门急诊片区及离异是临床护士情域能力的主要影响因素(P0.05,P0.01)。结论贵州省三级甲等综合医院临床护士情域能力处于较高水平,可制定针对性干预措施加强对低年资、无职务、学历较低、门急诊片区、离异护士情域能力的培训。     

骶管注射治疗腰椎间盘突出症的应用效果与优越性分析

目的:分析骶管注射治疗腰椎间盘突出症的应用效果与优越性.方法:选择参与研究病例数共有70例,均是腰椎间盘突出症患者,随机等分为两组,即对照组35例和实验组35例,前组患者以常规法治疗,后组患者以骶管注射治疗,对两组治疗效果进行观察和比较.结果:经2周的治疗,对照组优良率为74.3%,疼痛评分为4.55±1.21分;实验组优良率为91.4%,疼痛评分为3.02±1.07分.组间各数据相比较具有统计学意义(P均<0.05).结论:采用骶管注射治疗腰椎间盘突出症,可有效缓解患者腰腿痛症状,效果显著,推荐应用.     

口腔颌面部肿瘤术后吞咽障碍的评估和康复管理专家共识

手术治疗是口腔颌面部肿瘤的主要治疗手段,吞咽障碍是患者术后的常见并发症。吞咽障碍不但可导致误吸、营养不良、吸入性肺炎等严重后果,还可能引发心理问题和社会交往障碍,影响患者的生活质量。目前国内针对口腔颌面部肿瘤术后合并吞咽障碍的问题尚缺乏一个系统的评估和康复治疗管理方案。在前期临床实践的基础上,结合口腔颌面肿瘤患者术后吞咽障碍的特点及总结颌面肿瘤外科和康复领域专家的临床经验,回顾和总结国内外相关文献,组织相关专家经共同讨论,从吞咽障碍的筛查、评估和康复治疗管理的实施方案等核心内容方面达成共识,以期为临床相关工作提供参考。     

间充质干细胞在神经和运动系统相关疾病再生康复中的应用

再生康复是康复医学和再生医学的结合,有助于根据患者个体情况制定个性化治疗方案,促进患者的功能恢复,提高其生活质量。间充质干细胞具有自我更新、多能性、再生性和免疫调节等特点,在相关疾病的再生康复中发挥重要作用。本文对间充质干细胞在神经和运动系统相关疾病再生康复中的应用进展进行综述。     

急性脊髓损伤后继发肺损伤发生机制的研究进展

正急性脊髓损伤(acute spinal cord injury,ASCI)的常见致病原因为高坠伤和交通事故[1]。呼吸系统并发症是创伤性脊髓损伤患者急性期死亡的主要原因[2]。流行病学调查表明,ASCI后呼吸系统并发症的发生率为36%～83%,其中以肺炎、肺不张和呼吸衰竭最为常见[2]。颈髓损伤患者发生上述呼吸系统并发症的主要原因是膈肌及辅助呼吸肌瘫痪,导致呼吸受限、咳     

Noth2调控舌鳞癌干细胞的增殖、侵袭和迁移

BACKGROUND:Previous studies have found that the expression of Notch2 is up-regulated in tongue squamous cell carcinoma (TSCC) stem cells, but the effect of Notch2 on TSCC remains unclear. OBJECTIVE:To explore the effect of Notch2 on the proliferation, invasion and migration of TSCC stem cells (ALDH^br). METHODS:ALDHbr cells were enriched and separated by fluorescence-activated cell sorting technique from Tca8113 cells cultured in using serum-free medium, and Notch2 expression in ordinary TSCC cells (ALDH^low) and ALDH^br cells was detected by western blot. The ALDH^br cells transfected with Notch2 shRNA (sh-Notch2) by liposome served as experimental group, and ALDH^br cells transfected with sh-control were as control group. The effects of Notch2 on the proliferation, invasion and migration of ALDH^br cells were detected by cell counting kit-8 kit and Transwell assay, respectively. In addition, the expression levels of Ki67, matrix metalloproteinases 2 and 9 protein in Notch2-silenced ALDH^br cells and control cells were detected by western blot. RESULTS AND CONCLUSION:The expression level of Notch2 in ALDH^br cells was significantly higher than that in ALDH^low cells (P < 0.05). The ALDHbr cell proliferation ability and Ki67 protein expression in the experimental group were obviously lower than those in the control group (P < 0.05). The ALDH^br cell invasion and migration abilities in the experimental group were significantly lower than those in the control group (P < 0.05). The expression levels of matrix metalloproteinases 2 and 9 protein in the experimental group were obviously lower than those in the control group (P < 0.05). All these results show that Notch2 can promote the proliferation, invasion and migration of ALDH^br cells, which suggests that Notch2 plays an important role in the occurrence and development of TSCC, and it may be a potential molecular target for the treatment of TSCC.