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1.
目的估计浙江省海岛农村社区成年人代谢综合征发病情况, 探索该地区代谢综合征发病的相关影响因素。方法 2018年6-12月在浙江省玉环市对2012年开展的代谢综合征基线调查人群中无代谢综合征调查对象进行随访调查, 获取相关调查表信息以及实验室数据, 描述代谢综合征发病情况, 使用logistic回归探索发病危险因素及调整风险比(aRR)和95%CI。结果 3 162名随访对象中新发代谢综合征522例, 6年累积发病率为16.5%, 男女性累积发病率分别为12.3%、20.6%, 女性高于男性(P<0.001)。无业、吸烟、饮酒调查对象中代谢综合征发病率较高。女性(aRR=1.96, 95%CI:1.50~2.58)和高血压家族史(aRR=1.31, 95%CI:1.04~1.63)为代谢综合征发病独立危险因素。结论海岛农村社区成年人代谢综合征发病率相对较高, 其中女性以及有高血压家族史者发病风险更高。  相似文献   
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目的:分析血液纤维蛋白原和糖化血红蛋白水平与冠状动脉Gensini积分之间的相关性。方法回顾分析261例行冠状动脉造影及相关实验室检查的患者,根据Gensini积分及冠状动脉内径狭窄程度将患者分为A组(对照组,狭窄<50%,共46例),B组(冠状动脉狭窄≥50%,Gensini积分<20,共122例)、C组(冠状动脉狭窄≥50%, Gensini积分≥20,共93例),分析3组间血液纤维蛋白原和糖化血红蛋白等指标与Gensini积分的相关性。结果 A、B、C三组的血液纤维蛋白原、糖化血红蛋白、同型半胱氨酸、尿酸浓度均依次增高,差异有统计学意义(均 P<0.05);215例冠心病的纤维蛋白原和糖化血红蛋白与Gensini积分间均呈正相关(r=0.17、0.15,P<0.05)。结论血液纤维蛋白原和糖化血红蛋白浓度越高,冠状动脉狭窄越严重,可用于冠心病的早期危险性评估。  相似文献   
3.
目的研究B型钠尿肽(BNP)与肌酸激酶MB同工酶(CK-MB)在围产期子痫前期病情评估中的作用。方法回顾性分析82例孕妇临床资料,其中健康孕妇25例(A组)、轻度子痫前期患者18例(B组),未并发肺水肿的重度子痫前期患者22例(C组),并发心力衰竭肺水肿重度子痫前期患者17例(D组),检测产前6h内(T0)及产后6h内(T1)、产后24~36h内(T2)所测BNP、CK-MB浓度,并进行统计学分析。结果在T1时C组患者的BNP、CK-MB均高于A组和B组,差异均有统计学意义(t分别=6.50、6.54、3.73、2.46,P均<0.05);而D组患者较C组更高,差异均有统计学意义(t分别=7.38、3.69,P均<0.05)。线性相关性分析显示:C、D组T1时的CK-MB与BNP之间呈正相关(r分别=0.70、0.85、P均<0.05)。在T0时,D组患者的BNP、CK-MB均高于C组,差异均有统计学意义(t分别=11.61、3.43,P均<0.05),C组患者的BNP均高于A组和B组,差异均有统计学意义(t分别=6.99、6.60,P均<0.05),但A、B、C组间的CK-MB比较,差异均无统计学意义(t分别=0.47、1.30、0.74,P均>0.05)。结论 BNP及CK-MB可用于围产期子痫前期患者的病情评估,BNP的敏感性更优于CK-MB。  相似文献   
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 【摘要】目的 了解玉环农村社区≥35周岁居民的高血压患病率及知晓情况。方法 采用流行病学现况研究设计,面对面调查所有农村社区中35周岁及以上的社区户籍居民。采用SPSS16.0进行数据分析。按照2000年全国人口进行年龄标化。结果 在125 479名调查对象中,平均收缩压为(130.7±19.4) mmHg,舒张压为(76.0±10.4) mmHg,其中收缩压平均水平男性略高于女性,差异有统计学意义(t=14.51,P<0.001),舒张压平均水平亦如此(t=51.44,P<0.001)。高血压患病率为29.1%,标化患病率为25.9%,略有降低。不同性别人群的高血压患病情况略有不同:在50岁之前,男性高血压患病率高于女性,在50岁之后女性开始高于男性,性别差异有统计学意义(χ2=9.48,P=0.002)。从年龄分布看,35岁组患病率最低,在65岁之后超过一半的居民患高血压,不同年龄组之间的分布均有统计学差异。本次调查也发现,该人群高血压知晓率为85.4%。年龄、性别、文化程度、民族和职业与农村高血压居民知晓率有关。结论 浙江省玉环县农村社区35周岁及以上成人居民高血压患病率和知晓率均较高。  相似文献   
6.
目的探讨玉环地区医院门诊患者潜在医院感染的危险因素,提高临床对门诊感染的认识,降低门诊感染风险。方法选取门诊接诊初诊患者11 947例,对其临床资料进行回顾分析,根据是否发生医院感染分为感染组和非感染组,比较两组患者的个体因素及医疗因素,总结门诊患者潜在医院感染的风险因素。结果经Logistic回归分析,患者的年龄较小或者高龄、就诊儿科或者急诊、有侵入性操作、合并糖尿病是门诊患者发生医院感染的独立危险因素。结论在门诊患者治疗过程中,应对个体情况及治疗方案进行分析,综合评价患者发生医院感染的风险程度,采取针对性的医疗措施,有效降低医院感染率,提高临床治疗水平。  相似文献   
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BackgroundNonalcoholic fatty liver disease and its advanced stage, nonalcoholic steatohepatitis (NASH), are the major cause of hepatocellular carcinoma (HCC) and other end-stage liver disease. However, the potential mechanism and therapeutic strategies have not been clarified. This study aimed to identify potential roles of miRNA/mRNA axis in the pathogenesis and drug combinations in the treatment of NASH.MethodsMicroarray GSE59045 and GSE48452 were downloaded from the Gene Expression Omnibus and analyzed using R. Then we obtained differentially expressed genes (DE-genes). DAVID database was used for Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway analysis. Protein-protein interaction (PPI) networks were used for the identification of hub genes. We found upstream regulators of hub genes using miRTarBase. The expression and correlation of key miRNA and its targets were detected by qPCR. Drug Pair Seeker was employed to predict drug combinations against NASH. The expression of miRNA and hub genes in HCC was identified in the Cancer Genome Atlas database and Human Protein Atlas database.ResultsNinety-four DE-genes were accessed. GO and KEGG analysis showed that these predicted genes were linked to lipid metabolism. Eleven genes were identified as hub genes in PPI networks, and they were highly expressed in cells with vigorous lipid metabolism. hsa-miR-335-5p was the upstream regulator of 9 genes in the 11 hub genes, and it was identified as a key miRNA. The hub genes were highly expressed in NASH models, while hsa-miR-335-5p was lowly expressed. The correlation of miRNA-mRNA was established by qPCR. Functional verification indicated that hsa-miR-335-5p had inhibitory effect on the development of NASH. Finally, drug combinations were predicted and the expression of miRNA and hub genes in HCC was identified.ConclusionsIn the study, potential miRNA-mRNA pathways related to NASH were identified. Targeting these pathways may be novel strategies against NASH.  相似文献   
9.
正Hepatorenal fibrocystic diseases are inherited disorders,characterized by developmental abnormalities and fibrocystic degeneration of the portobiliary system and kidneys[1].They are part of a larger group of disorders referred to as"ciliopathies"which affect 1 in 1000 people.Polycystic kidney disease is the most common kidney manifestation,while others include nephronophthisis,  相似文献   
10.
BackgroundNonalcoholic fatty liver disease (NAFLD) is one of the main liver diseases, and its pathologic profile includes nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). However, there is no reliable non-invasive parameter in distinguishing NASH from NAFL in clinical practice. The present study was to find a non-invasive way to differentiate these two categories of NAFLD via lipidomic analysis.MethodsLipidomic analysis was used to determine the changes of lipid moieties in blood from 20 NAFL and 10 NASH patients with liver biopsy. Liver histology was evaluated after hematoxylin and eosin staining and Masson's trichrome staining. The profile of lipid metabolites in correlation with steatosis, inflammation, hepatocellular necroptosis, fibrosis, and NAFLD activity score (NAS) was analyzed.ResultsCompared with NAFL patients, NASH patients had higher degree of steatosis, ballooning degeneration, lobular inflammation. A total of 434 different lipid molecules were identified, which were mainly composed of various phospholipids and triacylglycerols. Many lipids, such as phosphatidylcholine (PC) (P-22:0/18:1), sphingomyelin (SM) (d14:0/18:0), SM (d14:0/24:0), SM (d14:0/22:0), phosphatidylethanolamine (PE) (18:0/22:5), PC (O-22:2/12:0), and PC (26:1/11:0) were elevated in the NASH group compared to those in the NAFL group. Specific analysis revealed an overall lipidomic profile shift from NAFL to NASH, and identified valuable lipid moieties, such as PCs [PC (14:0/18:2), PE (18:0/22:5) and PC (26:1/11:0)] or plasmalogens [PC (O-22:0/0:0), PC (O-18:0/0:0), PC (O-16:0/0:0)], which were significantly altered in NASH patients. In addition, PC (14:0/18:2), phosphatidic acid (18:2/24:4) were positively correlated with NAS; whereas PC (18:0/0:0) was correlated positively with fibrosis score.ConclusionsThe present study revealed overall lipidomic profile shift from NAFL to NASH, identified valuable lipid moieties which may be non-invasive biomarkers in the categorization of NAFLD. The correlations between lipid moieties and NAS and fibrosis scores indicate that these lipid biomarkers may be used to predict the severity of the disease.  相似文献   
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