全文获取类型
收费全文 | 57594篇 |
免费 | 4928篇 |
国内免费 | 1858篇 |
专业分类
耳鼻咽喉 | 666篇 |
儿科学 | 803篇 |
妇产科学 | 1180篇 |
基础医学 | 8527篇 |
口腔科学 | 1530篇 |
临床医学 | 5163篇 |
内科学 | 10730篇 |
皮肤病学 | 1063篇 |
神经病学 | 3901篇 |
特种医学 | 1829篇 |
外国民族医学 | 6篇 |
外科学 | 7940篇 |
综合类 | 5268篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 3519篇 |
眼科学 | 1447篇 |
药学 | 5213篇 |
中国医学 | 1094篇 |
肿瘤学 | 4495篇 |
出版年
2023年 | 232篇 |
2022年 | 332篇 |
2021年 | 627篇 |
2020年 | 456篇 |
2019年 | 686篇 |
2018年 | 1224篇 |
2017年 | 993篇 |
2016年 | 998篇 |
2015年 | 1184篇 |
2014年 | 1550篇 |
2013年 | 2004篇 |
2012年 | 2652篇 |
2011年 | 2652篇 |
2010年 | 1862篇 |
2009年 | 1742篇 |
2008年 | 2320篇 |
2007年 | 2403篇 |
2006年 | 2274篇 |
2005年 | 1864篇 |
2004年 | 1554篇 |
2003年 | 1433篇 |
2002年 | 1316篇 |
2001年 | 4702篇 |
2000年 | 4599篇 |
1999年 | 3942篇 |
1998年 | 1360篇 |
1997年 | 995篇 |
1996年 | 591篇 |
1995年 | 505篇 |
1994年 | 471篇 |
1993年 | 423篇 |
1992年 | 1938篇 |
1991年 | 1677篇 |
1990年 | 1529篇 |
1989年 | 1492篇 |
1988年 | 1298篇 |
1987年 | 1194篇 |
1986年 | 1064篇 |
1985年 | 900篇 |
1984年 | 593篇 |
1983年 | 471篇 |
1982年 | 251篇 |
1981年 | 182篇 |
1980年 | 142篇 |
1979年 | 282篇 |
1978年 | 77篇 |
1974年 | 76篇 |
1973年 | 98篇 |
1972年 | 72篇 |
1969年 | 67篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
目的 运用网络药理学方法及分子对接技术探讨黄芪干预腹膜纤维化的可能机制。方法 利用中药系统药理学数据库及分析平台(TCMSP)检索黄芪的主要化学成分及靶点,并补充文献报道相关药理作用的成分作为潜在活性成分。以"peritoneal fibrosis"为关键词分别在OMIM、Genecards获取目前已知的与腹膜纤维化相关的疾病靶点,后取两者的交集靶点;对交集基因通过STRING数据库与Cytoscape 3.7.2软件构建"药物-成分-靶点-疾病"网络及蛋白互作(PPI)网络并筛选核心网络。基于R软件使用Bioconductor生物信息软件对核心靶点进行GO及KEGG富集分析,最终采用AutoDock软件将主要有效成分与核心靶点进行分子对接,得出其结合能力。结果 筛选出20个黄芪活性成分及文献报道有相关药理作用4个, 457药物作用靶点,与674个腹膜纤维化病靶点取交集,得到86个共同靶点。GO功能富集分析提示黄芪拮抗腹膜纤维化主要参与了蛋白激酶B信号转导的调节、细胞对化学的应激反应、炎症反应的调节等通路; KEGG通路富集分析主要涉及调控肿瘤、磷脂酰肌醇-3-羟激酶-蛋白激酶B(PI3K-Akt)、晚期糖基化终末产物/晚期糖基化终末产物受体(AGE-RAGE)、人类巨细胞病毒感染、HIF-1信号通路等;分子对接结果显示关键靶点与活性成分具有较好的结合能力。结论 黄芪治疗腹膜纤维化的分子机制,可能与抑制炎症及氧化应激反应、调节多种信号通路等相关。 相似文献
2.
3.
M. Xiao H. Song Y. You M. Liu X. Yang Y. Wang 《International journal of oral and maxillofacial surgery》2021,50(4):437-443
Parotid lymph node (PLN) metastasis greatly worsens the prognosis of patients with oral squamous cell carcinoma (OSCC) and poses a great challenge for further treatment of OSCC. The clinicopathological characteristics and treatment strategies for PLN metastasis from OSCC need to be comprehensively elucidated. A retrospective review of OSCC patients who experienced postoperative PLN metastasis in our department between 2000 and 2018 was performed in this study. A total of 47 OSCC patients with postoperative PLN metastasis were identified. PLN with metastasis were divided into three groups based on the location: parotid tail (PLN-t), superficial lobe (PLN-sl), and deep lobe (PLN-dl). Most of the patients experienced PLN metastasis within less than 12 months after the primary surgery for OSCC. Comparatively, patients with PLN-sl metastasis were more prone to have infiltration of the facial nerve. The tongue and buccal mucosa were the most frequent primary sites associated with PLN metastasis from OSCC. PLNs in the parotid tail were most commonly affected by the metastasized OSCC. Consequently, we recommend a series of strategies for the prevention and treatment of PLN metastasis for OSCC patients. In conclusion, PLNs should not be overlooked during preoperative evaluation and postoperative follow-up examinations for OSCC patients. 相似文献
4.
M. Wang A. Abdelrehem X. Qu C. Zhang 《International journal of oral and maxillofacial surgery》2021,50(3):391-397
The objective of this study was to compare the implant longevity following two methods of peri-implant soft tissue optimization following free fibula flap (FFF): thinning of skin paddle (SP) and collagen matrix (CM). All patients who underwent rehabilitation with dental implants after mandibular reconstruction with FFF between June 2009 to May 2014 were retrospectively reviewed. Two methods of peri-implant soft tissue optimization were applied: (1) SP group, (2) CM group. Outcome measurements were: modified plaque index (mPI), modified sulcus bleeding index (mSBI), probing depth (PD), marginal bone loss (MBL), implant success rate and complication rates. A total of 24 patients with 69 implants were included in the study, with 8.7% (n = 6) of implants lost in 3 years. No statistically significant difference was found regarding the outcome measurements in both groups. Failed implants presented with statistically significant higher mPI, mSBI, PD and MBL scores during prosthesis delivery and subsequent follow-ups (P<0.03). In the SP group, one patient experienced SP necrosis which later underwent soft tissue optimization using CM. CM is an alternative peri-implant soft tissue, while thinning of SP is feasible if thickness is well controlled. 相似文献
5.
6.
7.
X. Elharrar M. Fortin E. Beguinot A.M. Dols L. Greillier Y. Martinet 《Revue d'épidémiologie et de santé publique》2019,67(3):181-187
Background
Prohibition of tobacco sales to minors is a provision of the World Health Organization Framework Convention on tobacco control. This measure is effective to reduce youth tobacco use, if the legislation adopted is properly implemented and enforced. Through the examples of France and Quebec, the objective of this study is to compare legislative frameworks prohibiting tobacco sales to minors, their enforcement, and possible impact on underage smoking.Methods
Identification of legislative instruments, reports from public health authorities, and articles addressing the focused question was performed trough Medline and Google.Results
Selling tobacco products to minors under 18 years of age has been banned by the law since 1998 in Quebec and 2009 in France. In 2011, in France for individuals aged 17, compliance with the law was 15%. In 2017 in France, 94% of 17-year-old daily smokers regularly bought their cigarettes in a tobacco store. Law enforcement controls and sanctions are non-existent. In 2013 in Quebec, 23% of underage smoking students usually bought their own cigarettes in a business. The compliance rate with the prohibition law rose from 37% in 2003 to 92.6% in 2017. An approach of underage “mystery shoppers” attempting to purchase tobacco products and dedicated inspectors has been implemented, and progressive sanctions are applied in case of non-compliance. In 2013, 12.2% of Quebec high school students and, in 2017, 34.1% of French 17 year olds reported using tobacco products in the last 30 days.Conclusion
Only an improved law enforcement, through the training of tobacco retailer's, inspections and effective deterrent penalties for non-compliance, leads to an effective legislative measure in terms of public health. 相似文献8.
9.
10.