首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   123篇
  完全免费   25篇
  基础医学   148篇
  2019年   4篇
  2018年   9篇
  2017年   6篇
  2016年   7篇
  2015年   7篇
  2014年   11篇
  2013年   8篇
  2012年   7篇
  2011年   9篇
  2010年   4篇
  2009年   3篇
  2008年   7篇
  2007年   10篇
  2006年   3篇
  2005年   4篇
  2003年   1篇
  2002年   1篇
  2001年   3篇
  1999年   1篇
  1997年   3篇
  1996年   1篇
  1995年   6篇
  1994年   1篇
  1993年   1篇
  1992年   3篇
  1991年   3篇
  1990年   1篇
  1989年   5篇
  1988年   2篇
  1986年   3篇
  1985年   4篇
  1982年   1篇
  1981年   2篇
  1979年   1篇
  1978年   1篇
  1977年   3篇
  1976年   1篇
  1974年   1篇
排序方式: 共有148条查询结果,搜索用时 31 毫秒
1.
同种与异种骨基质明胶修复颅骨缺损的实验研究   总被引:1,自引:1,他引:5  
以家兔颅顶骨直径10mm园形骨缺损作为动物模型,分别植入同种(兔)、异种(人、猪、羊)的骨基质明胶。植入后4、8、12、16w进行x线摄片和组织学检查。结果显示,同种骨基质明胶无免疫排斥反应,具有良好的骨诱导作用,术后12w骨缺损完全修复;异种骨基质明胶植入早期,存在着不同程度的排斥反应,植骨后期(12~16w),随着排斥反应的减轻,亦出现了诱导成骨。结果说明,如能改进异种骨基质明胶的制作方法,降低其抗原性,将具有重要的临床应用价值。  相似文献
2.
目的评价多孔纳米羟基磷灰石/壳聚糖﹙nHA/CS﹚支架与成骨细胞复合植入大鼠股部肌袋模型内的异位成骨能力。方法采用共沉淀和粒子沥滤法制备多孔nHA/CS。分离培养培养SD大鼠成骨细胞,并将其与多孔nHA/CS共同培养来构建组织工程骨。将所构建的组织工程骨和空白nHA/CS支架材料分别植入SD大鼠股部肌袋模型内。分别在植入2、4、6、8周后,将植入的支架材料取出行苏木精-伊红染色观察新骨形成情况,并应用JEDA-801D形态学图象分析系统来计算新骨生成率。用SPSS13.0软件包对测定结果进行单因素方差分析。结果在各观察时间段内成骨细胞复合多孔nHA/CS组新骨生成量均多于nHA/CS。结论多孔nHA/CS复合成骨细胞支架材料具有异位成骨能力。  相似文献
3.
CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta   总被引:1,自引:0,他引:1  
Autosomal dominant osteogenesis imperfecta (OI) is caused by mutations in the genes (COL1A1 or COL1A2) encoding the chains of type I collagen. Recently, dysregulation of hydroxylation of a single proline residue at position 986 of both the triple-helical domains of type I collagen alpha1(I) and type II collagen alpha1(II) chains has been implicated in the pathogenesis of recessive forms of OI. Two proteins, cartilage-associated protein (CRTAP) and prolyl-3-hydroxylase-1 (P3H1, encoded by the LEPRE1 gene) form a complex that performs the hydroxylation and brings the prolyl cis-trans isomerase cyclophilin-B (CYPB) to the unfolded collagen. In our screen of 78 subjects diagnosed with OI type II or III, we identified three probands with mutations in CRTAP and 16 with mutations in LEPRE1. The latter group includes a mutation in patients from the Irish Traveller population, a genetically isolated community with increased incidence of OI. The clinical features resulting from CRTAP or LEPRE1 loss of function mutations were difficult to distinguish at birth. Infants in both groups had multiple fractures, decreased bone modeling (affecting especially the femurs), and extremely low bone mineral density. Interestingly, "popcorn" epiphyses may reflect underlying cartilaginous and bone dysplasia in this form of OI. These results expand the range of CRTAP/LEPRE1 mutations that result in recessive OI and emphasize the importance of distinguishing recurrence of severe OI of recessive inheritance from those that result from parental germline mosaicism for COL1A1 or COL1A2 mutations.  相似文献
4.
The effect of a direct current on bone tissue was studied in experiments on rabbits. Passage of a current of 15–20 A through bone stimulates osteogenesis in the region of the cathode compared with the control (symmetrical bone of the same rabbit with implanted nonfunctioning electrodes), and in the case of fracture it promotes faster consolidation than in the control.Laboratory of Pathophysiology, R. R. Vreden Scientific-Research Institute of Traumatology and Orthopedics, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR, P. N. Veselkin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 78, No. 9, pp. 100–102, September, 1974.  相似文献
5.
Different relations between hematopoiesis and osteogenesis were observed in bone marrow grafts from rats, guinea pigs, and striped hairy-footed hamsters, transplanted beneath the renal capsule of irradiated mice. Active osteogenesis took place in grafts from rats and guinea pigs whereas hematopoiesis was observed irregularly (rats) or it ceased to occur (guinea pigs). In grafts from the hamsters, on the other hand, intensive hematopoiesis was maintained but the osteogenic properties of the stroma were weak. In some species the presence of bone tissue is considered to be not strictly essential for the normal maintenance of myeloid hematopoiesis whereas in others the initial development of a bony stroma is an essential condition for subsequent functioning of the hematopoietic tissue.Laboratory of Histogenesis, Institute of Biology of Development, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 2, pp. 231–234, February, 1976.  相似文献
6.
The combination of morphological and functional changes in the adrenal cortex after injection of thyrocalcitonin (TCT) and after experimental fracture was studied in 150 male albino rats. An increase in the functional activity of the gland was found during reparative osteogenesis. During administration of TCT (5 units daily) a state of hyperfunction develops in the first 5 days. Subsequent saturation with TCT caused inhibition of the adrenal and, in particular, of its glucocorticoid function. The inhibitory effect of TCT on the adrenal cortex, it is suggested, may be one of the mechanisms accelerating the course of repair processes in bone tissue.Department of Biology with General Genetics, Kalinin Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 10, pp. 484–487, October, 1977.  相似文献
7.
Exposure to a pulsed electric current during reparative regeneration of bone in rabbits resulted in stimulation of osteogenesis so that it predominated over fibro- and chondrogenesis to a greater degree than inthe control. The degree of mineralization of the microstructures was indistinguishable from the control.Laboratory of Biophysics, N. N. Priorov Central Scientific-Research Institute of Traumatology and Orthopedics, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR M. V. Volkov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 5, pp. 589–591, May, 1977.  相似文献
8.
The effect of the blood serum from animals with active osteogenesis on the biosynthesis of nucleic acids and protein and on mineralization of regenerating bone tissue was studied in experiments in vivo and in vitro. Incorporation of labeled precursors of DNA ([3H]thymidine) and protein ([14C]proline) in the recipients was intensified and mineralization of bony callus (incorporation of85Sr) was accelerated. Comparison of the order of stimulation of nucleic acid and protein synthesis suggests that the active principle of the serum promotes more rapid cell proliferation in the fracture zone.Laboratory of Pathophysiology and Laboratory of Biochemistry, Research Institute of Experimental and Clinical Orthopedics and Traumatology, Kurgan. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 12, pp. 725–727, December, 1977.  相似文献
9.
Experiments on rabbits showed that during plastic repair of a bone defect in the tibia by means of a muscle flap on a central vascular pedicle and electrical stimulation by a direct current of 18–20 A with change of polarity reorganization of the muscle flap was accelerated and bone tissue formed in its substance. Electrical stimulation of osteogenesis after muscle grafting promotes restoration of anatomic integrity of the bone.Department of Military Traumatology and Orthopedics, S. M. Kirov Military Medical Academy, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR I. S. Kolesnikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 3, pp. 356–359, March, 1978.  相似文献
10.
Mucopolysaccharide (MPS) metabolism in cultured skin fibroblasts was studied in one case of each of the following osteochondrodysplasias: chondrodysplasia punctata of the rhizomelic type, thanatophoric dysplasia, campomelic dysplasia, and osteogenesis imperfecta congenita. Accumulation of both sulfated and non-sulfated MPS, as well as secretion of total MPS, was normal in chondrodysplasia punctata of the rhizomelic type and in thanatophoric dysplasia. Accumulation of both sulfated and non-sulfated MPS was normal in campomelic dysplasia. Lastly, accumulation of sulfated MPS was normal in osteogenesis imperfecta congenita.  相似文献
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号