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1.
This study examined the contribution of daily experiences and acute exercise to fluctuations in feeling states of older, obese adults with knee osteoarthritis and explored the role of perceived physical function and general health perceptions as moderator variables. Using an experience sampling procedure, a total of 964 feeling state assessments were recorded and coded into samplings that occurred either on a nonexercise day or prior to or following scheduled activity on an exercise day. Multilevel modeling analyses controlling for the influence of subjective stress, contemporaneous pain reports, and diurnal variations revealed that physical exhaustion was higher immediately following exercise. Analyses of the moderator variables demonstrated that general health perceptions and perceived physical function accounted for significant portions of between-subject variance with more positive perceptions of each variable being related to higher levels of pleasant feeling states and lower feelings of physical exhaustion. However, perceived physical function and general health perceptions did not influence feeling states that emerged in conjunction with physical activity. The present findings suggest that whereas daily fluctuations in feeling states are influenced by perceived physical function and general health perceptions, older adults with knee OA do not exhibit the improvements in feeling states that have often been observed following acute exercise in younger, more physically active populations.  相似文献
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Genetic factors have been shown to play an important role in the etiology of osteoarthritis (OA). To elucidate the possible role of genetic variation in the estrogen receptors alpha and beta (ER-alpha, ER-beta) and androgen receptor (AR) genes with knee OA, the -1174(TA)(n), c.1092+3607(CA)(n), and c.172(CAG)(n) repeat polymorphisms of ER-alpha, ER-beta, and AR genes were studied. A case-control cohort of 158 patients with idiopathic knee OA and 193 controls were used. A significant difference was observed in the frequency distribution of -1174(TA)(9-25) and c.1092+3607(CA)(13-27) repeat polymorphisms of the ER-alpha and ER-beta genes between OA patients and controls (p<0.005 and p<0.0001, respectively). A significantly increased odds ratio (OR) for knee OA was observed in individuals having long alleles (LL) genotype for ER-alpha gene and LL and one short and one long allele (SL) genotypes for ER-beta gene compared to individuals with the short alleles (SS) genotype (95% CI 1.03-3.5; p=0.04 and CI 2.4-8.3 and 2.5-7.5; p < 0.001, respectively). When ORs were adjusted for various risk factors, it was observed that women with LL genotypes for ER-beta and AR genes showed significantly increased risk for OA development (p=0.002 and 0.001). An association between c.1092+3607(CA)(13-27) and c.172(CAG)(8-34) repeat polymorphisms of the ER-beta and AR genes and knee OA was found in individuals of Greek descent.  相似文献
3.
Joint pain is a primary symptom in knee osteoarthritis (OA), but the effect of pain and pain relief on the knee joint mechanics of walking is not clear. In this study, the effects of local knee joint analgesia on knee joint loads during walking were studied in a group of knee osteoarthritis patients. A group of healthy subjects was included as a reference group. The joint loads were calculated from standard gait analysis data obtained with standardised walking speed (4 km/h). The gait analyses were performed before and after pain relief by intra-articular injections of 10 mL lidocaine (1%). Pre-injection measurements revealed lower joint loads in the OA group compared to the reference group. Following injections pain during walking decreased significantly and the joint loads increased in the OA group during the late single support phase to a level comparable to the reference group. Although the patients walked with less compressive knee joint forces compared to the reference group, the effects of pain relief may accelerate the degenerative changes.  相似文献
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5.

Background

Physical activity and exercise is central to conservative management of knee osteoarthritis (KOA), but is often difficult for patients with KOA to maintain over the decade or more prior to surgical management. Better approaches are needed for maintaining physical function and health in this population that can also address the patho-biomechanics of the osteoarthritic knee.The objective of the study is to quantify how a lower-extremity robotic exoskeleton (dermoskeleton) modifies the external knee moments during over-ground walking in a sample of healthy adults, and to evaluate these biomechanical modifications in the context of the osteoarthritic knee.

Method

Motion analysis data was acquired for 13 participants walking with and without the dermoskeleton. Force plate data, external knee moment arms, and knee moments in the laboratory and tibia frames of reference were computed, as well as time–distance parameters of walking, and compared between the two conditions.

Results

Although gait speed was not different, users took shorter and wider steps when walking with the dermoskeleton. Ground reaction forces and early-stance knee moment increased due to the added mass of the dermoskeleton, but the knee adduction moment was significantly reduced in late stance phase of gait. There was no effect on the knee torsional moment when measured in the anatomical frame of reference, and the late-stance knee flexion moment was invariant.

Conclusions

The dermoskeleton demonstrated favorable biomechanical modifications at the knee in healthy adults while walking. Studies are warranted to explore this technology for enabling physical activity-based interventions in patients with KOA.  相似文献
6.
目的:探讨社会支持和心理资本对老年膝骨关节炎(knee osteoarthritis,KOA)患者自我感受负担的影响,并分析其影响路径.方法:采用社会支持评定量表(social support rating scale,SSRS)、心理资本量表(psychological capital questionnaire,PCQ)和自我感受负担量表(self-perceived burden scale,SBPS)对佛山市中医院就诊的383名老年KOA患者进行调查.结果:本组自我感受负担得分为33.82±9.13,处于中等水平;多元逐步回归分析结果显示社会支持与心理资本的自我效能、坚韧顽强、感恩奉献维度共可解释自我感受负担65.3%的方差变异量;进一步路径分析可知,社会支持对自我感受负担既有直接影响又有间接影响,自我效能、坚韧顽强、感恩奉献维度对自我感受负担具有直接影响.结论:老年KOA患者自我感受负担相对严重,护理人员可通过提升患者的社会支持和心理资本,以降低患者的自我感受负担水平,提高患者的心理健康水平.  相似文献
7.
Forefoot alignment may contribute to patellofemoral joint (PFJ) osteoarthritis (OA) via its influence on the closed chain kinematics of the lower limb. The purpose of this cadaveric study was to investigate the relationship between forefoot varus and ipsilateral cartilage damage in the medial and lateral PFJ. Forefoot alignment measurements were obtained from the feet of 25 cadavers (n = 50). Cartilage damage in the medial and lateral PFJ of each knee was scored using the Outerbridge scale. The relative odds of medial and lateral PFJ cartilage damage in limbs with forefoot varus and valgus were determined using logistic regression. The relationship between increasing varus alignment and increasing odds of medial and lateral PFJ cartilage damage was assessed. Of the 51% of limbs with forefoot varus, 91.3% had medial, and 78.3% had lateral PFJ cartilage damage, compared with 54.6% and 68.2% of those with forefoot valgus. The former also had 3.0 times (95% CI 1.2, 7.7) the odds of medial PFJ damage; no association was found with lateral damage (OR 1.4, 95% CI 0.7, 3.0). Feet in the highest tertile of varus alignment had 3.9 times (95% CI 10, 15.3, P = 0.058) the odds of medial PFJ damage as those in the lowest tertile. The results of this study suggest a relationship between forefoot varus and medial PFJ cartilage damage in older adults. As forefoot varus may be modified with foot orthoses, these findings indicate a potential role for orthoses in the treatment of medial PFJ OA. Anat Rec, 300:1032–1038, 2017. © 2016 Wiley Periodicals, Inc.  相似文献
8.
Objective: The aim of this study was to evaluate the effects of an aquatic exercise program and low-level laser therapy (LLLT) (associated or not) on degenerative modifications and inflammatory mediators on the articular cartilage using an experimental model of knee OA. Method: Forty male Wistar rats were divided into 4 groups: knee OA – without treatment (OA); OA plus exercise program group (OAE); OA plus LLLT (OAL); OA plus exercise program associated with LLLT (OAEL). Trained rats performed a water-jumping program carrying a load equivalent to 50-80 % of their body mass strapped to their chest. The laser irradiation was used either as the only method or after the exercise training had been performed, at 2 points contact mode (medial and lateral side of the left joint). The treatments started 4 weeks after the surgery, 3 days/week for 8 weeks. Results: The results revealed that all treated groups (irradiated or not) exhibited a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and improved chondrocytes organization. Also, a lower cellular density and structural damage (OARSI score) and higher thickness values were observed in all treated groups. Additionally, OAE and OAEL showed a reduced expression in IL-1β and caspase-3 as compared with OA. Furthermore, a statistically lower MMP-13 expression was only observed in OAEL as compared with OA. Conclusion: These results suggest that aquatic exercise program and LLLT were effective in preventing cartilage degeneration. Also, physical exercise program presented anti-inflammatory effects in the knees in OA rats.  相似文献
9.
膝关节单间室骨性关节炎引起的膝内翻是常见病症之一,目前手术方法主要有胫骨高位截骨术、单髁置换术以及最新推广的腓骨截骨术。单髁置换术自开展以来已有60余年历史,相比全膝关节置换术具有可保留膝关节正常运动、手术创伤小、保留骨量多以及术后关节活动度大等优点,故单髁置换术已成为治疗内侧间室骨关节炎一种可靠的治疗方式。腓骨截骨术是一种治疗膝内翻的新治疗手段,具有手术简单、费用低、恢复快等优点,目前正在被大力推广,但其治病机制尚不很清楚。综述单髁置换和腓骨截骨两种临床手术方式,并从生物力学角度推论腓骨截骨术治疗内侧间室骨性关节炎的可能机制,提出腓骨截骨术后外侧收缩肌力下降导致关节合力矩再平衡,故关节接触位置改变、关节接触力下降可能是腓骨截骨术能够缓解疼痛治疗骨性关节炎的原因。  相似文献
10.
Alterations in the contractile and non-contractile proteins of the skeletal muscle may reduce muscle function in knee osteoarthritis (OA), and the formation and accumulation of advanced glycation end products, particularly in collagen, can influence the quality of these muscle proteins. The objective of this study was to evaluate the reactivity of types I, III and IV collagen and the expression and localization of receptor for advanced glycation end products (RAGE) in the vastus lateralis (VL) muscle in early stages of knee OA. The hypothesis was that these patients present a higher expression of RAGE and increased immunoreactivity in the collagen. Thirty-five men were divided into two groups: the control group (CG; n?=?17) and the osteoarthritis group (OAG; n?=?18). All participants were submitted to a biopsy of the VL. The muscle samples were analyzed by immunohistochemistry for collagen and for RAGE and laminin. The expression of RAGE was counted (intracellular, extracellular and total). Student's t-test for independent samples and Mann–Whitney U test were used for the RAGE's intergroup analysis (α?≤?0.05). A semiquantitative analysis was performed to assess the collagen reactivity. No significant differences were observed in the intracellular, extracellular or total localization of RAGE (p?>?0.05). Higher immunoreactivity was observed in the OAG for all types of collagen, with more reactivity for collagen III and IV. We concluded that in the initial stages of knee OA, no differences were observed for RAGE levels between the groups. However, the OAG's higher collagen expression may represent adaptations for reducing muscle stiffness and avoiding injury.  相似文献
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