小剂量多巴胺对外科手术后患者的肾功能影响

目的 观察小剂量多巴胺是否对肾脏有保护作用。方法 对近2年来手术后的123例病人进行了研究,并随机分为2组,治疗组给予多巴胺以2～10ug/kg/min维持,连续7天。观察尿量、血肌酐及尿NAG、尿视黄醇结合蛋白变化。结果 治疗组与对照组尿量、血肌酐、尿NAG及尿RBP比较均无显著差异(P>0.05)。结论小剂量多巴胺常规应用于术后患者,难以发挥肾脏保护作用。     

Study of a Multicriterion Decision-Making Approach to the MQL Turning of AISI 304 Steel Using Hybrid Nanocutting Fluid

The enormous use of cutting fluid in machining leads to an increase in machining costs, along with different health hazards. Cutting fluid can be used efficiently using the MQL (minimum quantity lubrication) method, which aids in improving the machining performance. This paper contains multiple responses, namely, force, surface roughness, and temperature, so there arises a need for a multicriteria optimization technique. Therefore, in this paper, multiobjective optimization based on ratio analysis (MOORA), VIseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR), and technique for order of preference by similarity to ideal solution (TOPSIS) are used to solve different multiobjective problems, and response surface methodology is also used for optimization and to validate the results obtained by multicriterion decision-making technique (MCDM) techniques. The design of the experiment is based on the Box–Behnken technique, which used four input parameters: feed rate, depth of cut, cutting speed, and nanofluid concentration, respectively. The experiments were performed on AISI 304 steel in turning with minimum quantity lubrication (MQL) and found that the use of hybrid nanofluid (Alumina–Graphene) reduces response parameters by approximately 13% in forces, 31% in surface roughness, and 14% in temperature, as compared to Alumina nanofluid. The response parameters are analyzed using analysis of variance (ANOVA), where the depth of cut and feed rate showed a major impact on response parameters. After using all three MCDM techniques, it was found that, at fixed weight factor with each MCDM technique, a similar process parameter was achieved (velocity of 90 m/min, feed of 0.08 mm/min, depth of cut of 0.6 mm, and nanoparticle concentration of 1.5%, respectively) for optimum response. The above stated multicriterion techniques employed in this work aid decision makers in selecting optimum parameters depending upon the desired targets. Thus, this work is a novel approach to studying the effectiveness of hybrid nanofluids in the machining of AISI 304 steel using MCDM techniques.     

基于AO/PI荧光染色原理的杀伤细胞数量及活率检测方法学验证和细胞培养、冻存、复苏稳定性研究

目的 验证基于吖啶橙(AO)/碘化丙啶(PI)荧光染色原理的自动细胞分析仪检测细胞因子诱导的杀伤细胞(CIK)数量及活率的可行性,并对 CIK 细胞培养全过程及冻存复苏后至使用前过程进行检测,建立相应的数量及活率标准。方法 采集健康供者的外周血分离、培养 CIK 细胞,取培养过程中的细胞使用 AO/PI 荧光染色法、应用自动细胞分析仪检测细胞数量及活率,对结果的专属性、准确度、精密度、数量线性及范围、活率线性及范围进行验证。应用建立的方法对外周血分离后的外周血单个核细胞(PBMC)、培养过程中、冻存前及复苏后的 CIK 细胞数量及活率进行全过程检测。结果 专属性、准确度、精密度、数量线性及范围、活率线性及范围验证均符合预期要求。CIK 细胞培养全过程活率均不低于 80%,样本平均倍增时间为(42.26±1.17)h。冻存前的 CIK 细胞在加入含 5% DMSO 的冷冻保护剂后 90 min 内活率稳定,复苏后未经稀释或洗涤处理 120 min 内活率稳定,复苏后经洗涤去除 DMSO 处理后 12 h 内活率稳定。结论 基于AO/PI荧光染色原理的自动细胞分析仪可以用于检测 CIK 细胞的数量及活率,其结果可以用于细胞放行评价及稳定性研究。     

内蒙古自治区护理人员数量变化及其发展趋势预测

目的:分析护理人员的数量变化,发现其短缺的原因,并对护理人员的发展提出意见及建议。方法:选取2010—2018年内蒙古自治区护理人员的数量作为指数平滑法模型的基础,比较模型的不同条件,筛选出最优模型,预测2019—2030年护理人员的发展趋势。结果:护理人员发展呈现上升趋势,预计在2030年达到13.45万人,但护理人员的增长幅度逐渐趋于缓慢,年增长率降至3.40%。尽管护理人员总量上升,但医护比小,不能按时达到规划要求的1∶1.25。护理人员地区分布不均匀,呈现城市多、农村少的现象。结论:内蒙古自治区护理人员的数量仍有较大缺口,需要考虑医护合作和农村人群的需求。     

Association of sleep with moral severity to accidental harm transgressions: A cross-sectional study

Based on the assumptions that moral judgement activities require cognitive control, a capacity impaired by low sleep quality or a lack of sleep, several studies have explored the association between sleep and moral judgements. However, even if some studies support the association between sleep and both moral awareness and unethical behaviours, others failed to find a robust association between sleep and moral utilitarianism. In the present well-powered preregistered cross-sectional study, we explored the role of sleep in another class of moral judgement, namely third-party punishment (in which people have to assess the morality of an agent who transgressed a moral rule). Specifically, we targeted the association of sleep with judgements of accidental harm transgressions, which are assumed to be especially cognitively costly. Our main analysis showed no association of overall sleep quality during the past month with moral severity in these transgressions. This result was confirmed for other sleep indexes (sleep quantity in the past month, and sleep quantity and quality in the past night). Lastly, we exhaustively explored the associations of all sleep indexes with all classes of moral judgement (accidental, intentional, attempted transgressions and control scenarios). These additional results revealed associations between sleep and moral severity, but none survived correction for multiple testing. Equivalence tests confirmed that the effect sizes of all these associations were relatively low (|r < 0.25|). We ensured that the lack of robust association between natural sleep and third-party punishment could not be explained by a low quality of the data collected.     

Bedtime procrastination mediates the relation between anxiety and sleep problems

The prevalence of sleep problems is high in primary care patients and in anxious individuals. This study assessed whether total sleep time and bedtime procrastination mediated the association between anxiety and sleep problems. We predicted higher anxiety would be negatively associated with total sleep time and positively associated with bedtime procrastination and sleep problems, and these variables would statistically mediate the association between anxiety and sleep problems. Participants were 308 adult primary care patients, predominantly female (non-Hispanic White = 158, Latinx = 111, mean age = 33.30), who initiated behavioral health services at an integrated primary care clinic. Patients completed a questionnaire regarding psychological health and sleep behaviors. Using structural equation modeling, we found higher anxiety related to higher sleep problems, partially mediated by bedtime procrastination but not total sleep time. This study highlights related factors like anxiety and prebedtime behaviors that may be effective treatment targets for sleep challenges.