Measles virus and Guillain-Barré syndrome during long-term hemodialysis.

In a black man, recently receiving long-term hemodialysis, a severe, rapidly progressive polyradiculoneuritis (Guillain-Barre syndrome) developed. Routine virologic study revealed a high antimeasles virus antibody titer (1:1280 by hemagglutination-inhibition) which progressively decreased. There was no clinical evidence of measles. Discussed here is the possible relationship between the Guillain-Barre syndrome and clinically inapparent measles associated with and perhaps modified by the uremic state.     

Immunologically-mediated acute renal failure of nonglomerular origin in the course of systemic lupus erythematosus [SLE]. Report of two cases.

Acute anuric renal failure was observed in two patients with systemic lupus erythematosus (SLE) during the clinical and serologic active phase of the disease. Renal biopsies, performed during the acute episodes, showed only mild and focal mesangial cell proliferation without deposits. In contrast, tubulointerstitial lesions were predominant. Intense granular immune deposits along the tubular basement membrane, or immunofluorescence examination, were suggestive of immune complex deposition. One of these patients had severe high blood pressure and vascular lesions likely induced by immune complexes. In both, renal function was recovered. Immunologically-mediated tubular and vascular lesions in the course of SLE are discussed.     

Menzel's hereditary ataxia with slow eye movements and myoclonus: A clinico-pathological study

The patient we describe had cerebellar ataxia, slow eye movements, myoclonus, facial dystonia and signs of spinal cord and peripheral nerve involvement. The patient's mother, brother and sister died from the same disease. Neuropathological examination revealed lesions of olivo-ponto-cerebellar atrophy (OPCA) associated with spinal cord degenerative changes characteristic of Menzel's hereditary ataxia.Although myoclonus was similar to Hunt's dyssynergia cerebellaris myonica, pathological findings did not show significant involvement of the dentate nucleus or superior cerebellar peduncle and physiopathological hypotheses for myoclonus are discussed.Slow eye movement is emphasized in the propositus and we suggest that it could be specific of one type of OPCA. Its pathological significance is discussed, but a primitive and unique involvement of the paramedian pontine reticular formation is unlikely.     

Salvage cryoablation for local recurrence of prostatic cancer after curative therapy

PurposeThe purpose of this study was to determine the efficacy of salvage cryotherapy for intra-prostatic and local extraprostatic recurrences after curative treatment of prostate adenocarcinoma.Material and methodTwenty-eight men (mean age, 69 ± 6 [SD] years; range: 51–82 years) treated with cryoablation for prostatic (N = 21) or extraprostatic (N = 7) recurrent prostate cancer after radiotherapy with or without associated prostatectomy were included. Technical success, complication and recurrences were reported. Biological recurrence was defined as an elevation ≥ 2 ng/mL of prostate specific antigen (PSA) serum level after the treatment.ResultsThe mean follow-up was 18 months. Among the 21 patients with intraprostatic recurrence, 14 had successful cryotherapy with a mean decrease in serum prostate-specific antigen (PSA) levels of ? 5.7 ± 2.6 (SD) ng/mL (range: ? 2.1 to ? 16.9 ng/mL). Four patients (19%) had early progression and three patients (14%) had delayed biological recurrence (mean time: 15 months). Among the 7 patients with extraprostatic recurrence, 2/7 (291%) had successful cryotherapy with a decrease in PSA serum level of ? 2.7 ± 1.6 (SD) ng/mL (range: ? 0.5–? 5.5 ng/mL) and 4/7 (57%) had early biological recurrence after cryotherapy that required androgen deprivation therapy, whereas 1/7 (4%) was lost to follow-up. No major complications were observed for both intra- and extraprostatic recurrence.ConclusionSalvage cryoablation of locally recurrent prostate cancer after curative treatment is feasible and safe when the half prostate is treated. It could delay initiation of androgen deprivation therapy in these patients.     

Extract of Paris polyphylla Simth protects cardiomyocytes from anoxia-reoxia injury through inhibition of calcium overload

Objective  

To assess any direct effect of extract of Paris polyphylla Simth (EPPS), a Chinese plant, on a cardiomyocyte subject to ischemia-reperfusion injury and to further elucidate its protective effect against myocardium ischemia on the cellular level.     

基于SSR分子标记的滇重楼遗传多样性研究

目的研究滇重楼Paris polyphylla var.yunnanensis自然居群的遗传多样性,为滇重楼资源的保护和合理利用提供数据。方法采用SSR分子标记对滇重楼5个不同居群共115份样品进行遗传多样性分析。结果筛选出8对可用SSR引物,多态位点百分率(PPB)为100%,多态信息量(PIC)为0.745 6。在居群水平和物种水平上,观测等位基因数(N_a)分别为8.425 0和17.750 0,有效等位基因数(N_e)分别为4.960 9和7.500 7,观测杂合度(H_o)分别为0.295 5和0.294 8,期望杂合度(H_e)分别为0.654 8和0.774 4,Shannon’s信息指数(I)分别为1.520 1和2.038 6。遗传分化系数(F_(st))为0.172 8,基因流(N_m)为1.196 6。利用UPGMA聚类分析,将5个居群分为2类。结论滇重楼遗传多样性水平较高,居群内和居群间具有一定的遗传分化。对保护和发展滇重楼资源提出若干措施,为滇重楼的保护和科学可持续利用提供参考。     

滇重楼根际微生物分布与甾体皂苷含量的相关性

观察了滇重楼栽培中根际土壤细菌、真菌、放线菌和3类促生细菌数量的变化规律,探讨了根际土壤微生物数量与滇重楼品质的关系。结果表明,滇重楼植物根际土壤微生物资源丰富,不同产地滇重楼根际土壤细菌、真菌、放线菌、解钾细菌、解无机磷细菌和解有机磷细菌数量具有显著性差异(P<0.05),根际土壤微生物数量的分布规律是:细菌数量>放线菌数量>真菌数量。随着种植年限的增加,真菌与解钾细菌数量呈逐年增加,细菌、放线菌、解无机磷细菌与解有机磷细菌数量呈逐年减小的变化趋势,土壤微生物类型由"细菌型"向"真菌型"过渡。不同产地滇重楼根茎的药用品质具有生境依赖性,种植年限的增加造成滇重楼药用品质下降作用明显。由此可见,种植年限增加会引起土壤微生态区系的变化,降低了滇重楼对营养物质的吸收利用,进而造成滇重楼药用品质下降。     

Repeat hemodynamic determinations in borderline hypertension

Repeat hemodynamic determinations were performed in 37 young men with borderline hypertension. The duration of the follow up study was 47 ± three months. At each determination, those with borderline hypertension were compared to a group of matched normal subjects. Blood pressure increased from the first to the second determination, but the increase was significant only for systolic (P < 0.001) and mean (P < 0.01) arterial pressures. Cardiac index and heart rate, which were initially increased, decreased significantly (P < 0.02; P < 3.01, respectively) and decreased to normal values; total peripheral resistance increased (P < 0.01); blood and plasma volumes decreased (P < 0.01). At the first determination, the cardiac index-heart rate correlation was significant (P < 0.01) and the cardiac index-blood volume correlation was not. At the second determination, on the contrary, the cardiac index-total blood volume correlation was significant (P < 0.001) whereas the cardiac index-heart rate correlation was not. The study provides evidence that patients with borderline hypertension, over a short-term period, show (1) a greater increase in systolic than in diastolic pressure, (2) a return of cardiac output toward normal values through a decrease both in heart rate and blood volume, and (3) an increased importance of volume factors in the cardiac output control.