“小棉袄”为何变成“小刺猬”?

天色渐晚,我守在小区门口四处张望。中午,女儿在盛怒之下出了门,到现在也没回来。记不清是从什么时候开始,她挣脱了我的怀抱,从贴心的"小棉袄",变成了一只扎人的"刺猬"。今天,我和女儿之间起了这个     

从优秀到卓越的秘诀

古希腊诗人Archilochus曾说过这样的一句话：“狐狸千伎百俩而有尽，刺猬凭一技之长而无穷。”千百年后，英国犹太裔思想史家伯林受此启发，将思想史上的思想家划分为狐狸型思想家和刺猬型思想家。与此类似，在企业界也同样存在刺猬型企业与狐狸型企业，前者始终明白自己的专注方向，集中所有的资源进行深耕细作，后者则战线拉得很长，业务头绪繁多。     

甜蜜的夫妻也应亲密有间

人们常用"亲密无间"比喻友情、亲情的深厚,其实,任何"无间"的东西并不能获得恒久,恰恰是"有间"才能维护亲情。两只相爱的刺猬,由于寒冷而拥抱在一起,可因为身上都长着刺,于是它们离开了一段距离,但又冷得受不了,于是又凑到一起。几经折腾,两只刺猬终于找到了一个合适的距离,既能互相获得对方的温暖而又不致于被扎。"有间"就是距离感。     

糖刺猬的想念

当某种东西消失了．我们会说．想念。 比如一只丢掉的耳环。找不到的书。坏掉的闹钟。远方的人。 春节的时候．很想念曾经的糖刺猬。     

Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/Akt signaling pathways

AIM: To investigate the effects of Sonic hedgehog (shh) protein on bone marrow- derived endothelial progenitor cells (BM-EPC) proliferation, migration and vascular endothelial growth factor (VEGF) production, and the potential signaling pathways involved in these effects. METHODS: Bone marrow-derived Flk-1(+) cells were enriched using the MACS system from adult Kunming mice and then BM-EPC was cultured in gelatin-coated culture dishes. The effects of shh N-terminal peptide on BM-EPC proliferation were evaluated using the MTT colorimetric assay. Cell migration was assayed using a modified Boyden chamber technique. The production of VEGF was determined by ELISA and immunofluorescence analysis. The potential involvement of PKC and PI3K signaling pathways was explored using selective inhibitor or Western blot. RESULTS: The proliferation, migration and VEGF production in BM-EPC could be promoted by endogenous shh N-terminal peptide at concentrations of 0.1 microg/mL to 10 microg/mL, and could be inhibited by anti-shh antibodies. Shh-mediated proliferation and migration in BM-EPC could be partly attenuated by anti-VEGF. Phospho-PI3-kinase expression in newly separated BM-EPC was low, and it increased significantly when exogenous shh N-terminal peptide was added, but could be attenuated by anti-human/mouse shh N-terminal peptide antibody. Moreover, the inhibitor of the PI3-kinase, but not the inhibitor of the PKC, significantly inhibited the shh-mediated proliferation, migration and VEGF production. CONCLUSION: Shh protein can stimulate bone marrow-derived BM-EPC proliferation, migration and VEGF production, which may promote neovascularization to ischemic tissues. This results also suggests that the PI3-kinase/Akt signaling pathways are involved in the angiogenic effects of shh.     

刺猬饲养繁殖与剪刺

１９９２年我们研制了“复方三七胶囊”，经临床使用观察治疗痔疮有效率８０％以上，其中三七与刺猬刺各占１／２。用其刺有多项优点［１］，主要是药用成分增多（活血收敛的成分在刺中而不在皮中），刺猬剪刺后能继续饲养繁殖与剪刺。具体做法介绍如下。１刺猬的习性与场...     

养血活血健胃法治疗慢性萎缩性胃炎／朱菊英／／中国医学文摘

本组70例,用黄芪、党参、丹参各20g,白芍、淮山药、川芎各15g,黄芩、当归各10g,刺猬皮、乌梅各9g,凤凰衣、生甘草各6g,公英30g。阳虚加附子;阴虚加沙参、麦冬;腹胀去黄芪、淮山药,加苏梗、佛手片、绿萼梅;隐痛加九香虫。     

铁介导骨代谢异常中“刺猬信号通路” 可能的作用

近年来有许多研究提示：铁代谢与骨质疏松症关系密切,铁过载可能引起骨代谢异常。在铁代 谢与骨代谢异常的相关机制中,许多研究认为刺猬信号通路（hedgehog信号通路,Hh信号通路）在 “铁介导骨代谢异常”中起着重要作用,本文将相关研究文献进行梳理综述。     

Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis

INTRODUCTION Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract that occur from the esophagus to the anus, including in the omentum, mesentery and retroperitoneum[1]. Small GISTs are often detected during surgery for other conditions, gastroscopy or routine X-ray[1,2]. Some GISTs present with bleeding, perforation, pain, obstruction or a combination of these symptoms[3,4]. These tumors have a wide clinical spectrum from benign, incidenta…     

Hh信号通路在氟致大鼠原代软骨细胞损伤中作用

目的 探讨体外染氟软骨细胞中刺猥蛋白基因(Hh)信号通路中音速刺猬蛋白、跨膜蛋白(Smo)及下游骨形态发生蛋白-2(BMP-2)因子表达在氟中毒软骨细胞损伤中的作用.方法 取1周龄健康SD大鼠,用机械、酶消化法分离膝关节软骨细胞,免疫细胞化学对原代软骨细胞进行鉴定.实验设对照组和染氟组(5、10、20、40 mg/L).培养48 h后,噻唑蓝法检测各组细胞活力,蛋白印迹及逆转录PCR分别检测各组细胞Smo、Shh、BMP-2蛋白及mRNA表达;流式细胞术检测各组细胞凋亡情况.结果 与对照组比较,5、10 mg/L染氟组细胞活力[分别为(113.33±11.74)％、(127.25±10.24)％]明显升高,40 mg/L染氟组细胞活力[(73.91±9.94)％]明显下降(P＜0.05);染氟组细胞中Shh、Smo、BMP-2蛋白和mRNA的表达量随染氟浓度增加而升高;40 mg/L染氟组细胞凋亡率为(11.13±1.20)％,明显高于对照组.结论 氟可激活软骨细胞中Hh信号通路,Hh信号通路与软骨细胞凋亡可能共同参与氟中毒软骨损害过程.