Primary localized stages I and II non-Hodgkin’s lymphoma of the nasopharynx: a retrospective 17-year single institutional experience

The aim of this retrospective study was to define the natural history, clinicopathological findings, prognostic factors, and treatment outcome of 43 patients with localized stages I and II primary non-Hodgkin’s lymphoma (NHL) of the nasopharynx, followed up in a single institution over a 17-year period. Forty-three (13 women and 30 men) consecutive patients with localized stages I (N = 12) and II (N = 31) primary nasopharyngeal NHL were treated in our institution between 1990 and 2007. The pathologic reports were classified according to the International Working Formulation (N = 22) or Revised European-American Lymphoma classification (N = 21). The vast majority of patients (88%) were managed with a sequential combination of chemotherapy and radiation therapy. Chemotherapy mainly consisted of 4–8 (median 6) cycles of CHOP regimen (cyclophosphamide, doxorubicin, vincristine and prednisolone). Involved-field radiation therapy with a median dose of 44 Gy was delivered to the primary site and entire cervical lymph nodes. The median age of the patients was 53 years (range, 6 to 86 years). The majority of the patients (70%) had high-grade histology. B-cell types represented 67% of the cases, among which diffuse large B cell was the most common histological subtype. After a median follow-up of 70 months, the 5-year disease-free survival and overall survival were 58.8% and 70.6%, respectively. In multivariate analysis, age less than or equal to 30 years (hazard ratio (HR) = 5.32, 95% confidence interval (CI) = 1.69–16.76), elevated serum lactate dehydrogenase level (HR = 3.69, 95% CI = 1.43–9.51), and modified International Prognostic Index with more than or equal to two risk factors (HR = 17.99, 95% CI = 2.32–139.30) retained statistical significance. Our limited data suggest that primary nasopharyngeal NHL tends to have aggressive histology and unfavorable clinical course with poor outcome, despite a considerably localized disease at the time of presentation and high frequency of complete initial response rates. Combined modality therapy should be considered for the majority of patients with primary localized nasopharyngeal NHL.     

整体护理对预防鼻咽癌放射治疗患者口腔黏膜炎的效果评价

目的 探讨整体护理对预防鼻咽癌放射治疗患者口腔黏膜炎的应用效果.方法 将102例接受放射治疗的鼻咽癌患者随机分为对照组和干预组,每组51例,对照组采用常规护理,干预组采用整体护理,比较两组患者口腔黏膜炎的发生率及严重程度.结果 干预组口腔黏膜炎发生率明显低于对照组,严重程度较对照组轻,差异有统计学意义(x2 =4.15,P＜0.05).结论 整体护理能降低鼻咽癌放射治疗患者口腔黏膜炎的发生率,减轻口腔黏膜炎严重程度,提高患者生存质量.     

Choanal fungus ball mimicking a tumour

We report the first case of an isolated choanal fungus ball in a 28-year-old man with a previous history of nasopharyngeal carcinoma, who was treated with radiotherapy 14 years ago. The initial diagnosis was a recurrent tumour or a secondary neoplasm. Histopathological examination confirmed a fungal infection. There are no previous reports of a fungus ball located at the posterior choanal region. Although it has been reported that bacteriology of sinonasal region would be different in irradiated patients, there is no study reporting fungal infections in irradiated patients in English literature.In this report, the clinical presentation, relevant radiologic findings and management of sinonasal fungus ball and its relationship with previous radiotherapy were discussed with the literature knowledge.     

鼻咽部淋巴瘤的影像诊断及鉴别诊断

目的：探讨鼻咽部淋巴瘤的影像特征及鉴别诊断。方法：回顾性分析我院经病理证实累及鼻咽部的18例恶性淋巴瘤的影像资料。结果：病变表现为单侧或双侧肿块12例,软组织增厚6例,淋巴结肿大13例,12例鼻咽部肿块轻中度强化。病变可浸润鼻腔、口咽、舌根及扁桃体,与头长肌可分界。结论：鼻咽部恶性淋巴瘤的影像表现有一定特征,CT及MR I能够显示病变的范围和浸润的程度,并与鼻咽部炎症及鼻咽癌鉴别。     

小儿鼾症鼻咽部侧位片105例X线分析

目的：通过对105例小儿鼾症鼻咽部侧位片的X线观察,探讨简便及适合基层医院的判断腺样体大小的检查方法。方法：105例小儿鼾症均照鼻咽部侧位片,采用A/N法测量及平行曲线法测量腺样体。结果：38例A/N≤0.6,59例A/N0.61~0.7,8例A/N≥0.71。结论：鼻咽部侧位片是了解腺样体大小的简便廉价有效的方法,可常规作为首选。     

数字化鼻咽侧位影像在儿童腺样体肥大的诊断中的价值

目的:探讨直接数字化X线摄影(DR)鼻咽侧位片在儿童腺样体肥大的诊断中的价值.方法:采用鼻咽侧位片腺样体-鼻咽腔(A/N)比率测量值,结合临床症状及纤维鼻咽镜检查儿童腺样体的分度范围(Ⅰ-Ⅳ°)进行影像诊断.结果:112例A/N在0.61-0.89之间的患儿,经保守治疗无效,再经低温等离子射频切割消融术治疗后痊愈出院....     

An Atypical Rare Case of Extracranial Craniopharyngioma

We present a case of a purely extracranial, infrasellar craniopharyngioma that initially presented as a mass in nose and nasopharynx. Craniopharyngiomas are usually located within the sella. Purely infrasellar craniopharyngiomas have only rarely been reported in the literature. A 55-year-old man presented with 8-month history of progressive headache and epistaxis. Rhinoscopy revealed polypoidal mass in both the nasal cavities and nasopharynx. Pre-operative biopsy suggested Craniopharyngioma. A battery of tests necessary for the diagnosis of Craniopharyngioma was done which excluded other possibilities. Surgical resection was done and histopathology thereafter was confirmatory of Craniopharyngioma. Adjuvant radiotherapy was given to the patient. The patient is doing well. The Rathke’s pouch arises from the roof of the primitive mouth and grows toward the brain at the fourth week of gestation. Normally, it loses its attachment with the stomadeum completely by the eighth week of gestation. The craniopharyngeal canal (CPC) extends from the floor of the sella to the vomer and may rarely give rise to ectopic craniopharyngiomas. This case shows that such ectopic tumors may arise anywhere along the CPC. We are documenting this case as an atypical rare case of craniopharyngioma probably originating from tooth primordia.     

鼻咽部滤泡树突状细胞肉瘤的临床病理观察

目的探讨鼻咽部滤泡树突状细胞肉瘤的临床病理特点、诊断及鉴别诊断要点。方法回顾分析2例鼻咽部滤泡树突状细胞肉瘤的临床表现、影像学、组织病理学特点及免疫组化表型。结果 2例均为女性,年龄分别为53岁和56岁。肿物最大径分别为4.4 cm和4 cm。2例肿瘤均由梭形细胞组成,细胞片状排列,局部略呈车辐状、束状、旋涡状,细胞异型性不明显。免疫组化:vimentin、CD21和CD23均(+),CK(-);例1 EMA(+),CD35(-),EB病毒(+);例2 CD35(+),EMA(-),EBV(-)。例1放弃治疗,随访2个月,目前带瘤生存;例2接受了肿物扩大切除,术后25个月复发,拒绝再次手术,目前带瘤生存32个月。结论鼻咽部滤泡树突状细胞肉瘤非常罕见,明确诊断需结合组织病理学形态、免疫组化表型及EB病毒检测。     

Rhabdomyosarcoma of nasopharynx

Rhabdomyosarcoma is a highly invasive malignant tumour arising from the mesenchymal tissue. Here, we reported a rare case of embryonal rhadomyosarcoma of nasopharynx with extension to different spaces of base of skull and orbit. Rarity of the case difficulty in diagnosis encourages its reporting.