首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   384篇
  免费   12篇
  国内免费   30篇
儿科学   2篇
基础医学   29篇
临床医学   17篇
内科学   6篇
神经病学   45篇
特种医学   8篇
外科学   233篇
综合类   43篇
预防医学   3篇
药学   20篇
中国医学   6篇
肿瘤学   14篇
  2024年   1篇
  2023年   3篇
  2022年   11篇
  2021年   16篇
  2020年   8篇
  2019年   10篇
  2018年   13篇
  2017年   11篇
  2016年   10篇
  2015年   14篇
  2014年   30篇
  2013年   26篇
  2012年   29篇
  2011年   26篇
  2010年   25篇
  2009年   22篇
  2008年   16篇
  2007年   19篇
  2006年   15篇
  2005年   15篇
  2004年   15篇
  2003年   14篇
  2002年   8篇
  2001年   9篇
  2000年   7篇
  1999年   9篇
  1998年   10篇
  1997年   4篇
  1996年   3篇
  1995年   2篇
  1994年   1篇
  1993年   3篇
  1992年   5篇
  1990年   5篇
  1988年   2篇
  1987年   1篇
  1986年   1篇
  1985年   1篇
  1984年   2篇
  1983年   2篇
  1980年   1篇
  1979年   1篇
排序方式: 共有426条查询结果,搜索用时 0 毫秒
411.

Background context

A few reports have addressed tethered cord syndrome. Detethering surgery has been performed in these cases because abnormal tension on the spinal cord causes neurologic and urologic symptoms.

Purpose

To discuss the surgical treatment of tethered cord syndrome with the belief that the tension on the cord can be decreased by shifting tethered cord to the dorsal side.

Study design

A patient with tethered cord syndrome was surgically treated by shifting the tethered cord to the dorsal side by harnessing the lumbar lordosis instead of detethering.

Methods

We performed surgery to shift the tethered cord to the dorsal side by harnessing the lumbar lordosis to decrease the tension on the spinal cord.

Results

The tethered cord that was pressed to the ventral side because of a lipoma was shifted dorsally by laminectomy and opening of the dural sac. Pain and numbness were alleviated immediately after surgery.

Conclusions

The method used in the present case, that is, shifting the tethered cord and lipoma to the dorsal side by harnessing the lumbar lordosis instead of detethering, is a viable treatment option for tethered cord syndrome.  相似文献   
412.
BackgroundThe biomechanical effect of a bifid arch as seen in spina bifida occulta and following a midline laminectomy is poorly understood.PurposeTo test the hypothesis that fatigue failure limits will be exceeded in the case of a bifid arch, but not in the intact case, when the segment is subjected to complex loading corresponding to normal sporting activities.Study designFinite element analysis.MethodsFinite element model of an intact L4-S1 human lumbar motion segment including ligaments was used. A section of the L5 vertebral arch and spinous process was removed to create the model with a midline defect. The models were loaded axially to 1 kN and then combined with axial rotation of 3°. Bilateral stresses, alternating stresses, and shear fatigue failure on both models were assessed and compared.ResultsUnder 1 kN axial load, the von Mises stresses observed in midline defect case and in the intact case were very similar (differences <5 MPa) having a maximum at the ventral end of the isthmus that decreases monotonically to the dorsal end. However, under 1 kN axial load and rotation, the maximum von Mises stresses observed in the ipsilateral L5 isthmus in the midline defect case (31 MPa) was much higher than the intact case (24.2 MPa), indicating a lack of load sharing across the vertebral arch in the midline defect case. When assessing the equivalent alternating shear stress amplitude, this was found to be 22.6 MPa for the midline defect case and 13.6 MPa for the intact case. From this, it is estimated that shear fatigue failure will occur in less than 70,000 cycles, under repetitive axial load and rotation conditions in the midline defect case, whereas for the intact case, fatigue failure will occur only after more than 10 million cycles.ConclusionsA bifid arch predisposes the isthmus to early fatigue fracture by generating increased stresses across the inferior isthmus of the inferior articular process, specifically in combined axial rotation and anteroposterior shear.  相似文献   
413.
目的观察前路选择性椎间隙减压组合椎体次全切除术治疗多节段脊髓型颈椎病(CSM)的疗效。方法选择20例累及3个节段行前路选择性椎间隙减压组合椎体次全切除术的CSM患者为研究对象即观察组,选择同期收治的20例行两椎体次全切除长节段植骨融合内固定术治疗多节段CSM患者为对照即对照组,观察比较两组手术时间、术中出血量、住院时间,术后影像学评估内固定稳定性、颈椎生理曲度改变以及植骨融合率,参照日本骨科协会(JOA)评分标准评估两组患者神经功能改善情况,评价其治疗效果。结果观察组手术时间、术中出血量以及住院时间优于对照组(t=12.724、28.657、9.573,均P〈0.01),两组患者术后临床症状均有不同程度改善,JOA评分和Odom优良率观察组(95%和90%)明显优于对照组(70%和70%)(X^2=5.45、9.02,均P〈0.05)。两组患者在术后及随访期间x线片复查均未见钛板、钛网松动和移位,骨性融合率为100%,生理曲度恢复正常,颈椎稳定性良好。两组患者在术后2d和9个月融合节段Cobb角和术前比较明显改善(t=7.364、11.259,均P〈0.01),术后9个月角度丢失率观察组明显小于对照组(t=13.579,P〈0.01)。结论临床上治疗多节段CSM采用前路选择性椎间隙减压组合椎体次全切除术疗效显著,能兼顾减压以及保留颈椎结构,是减少并发症的一种安全且有效的手术方法,值得在临床上广泛推广和应用。  相似文献   
414.

Purpose  

The purpose of our paper is to illustrate our experience with minimally invasive approaches for the treatment of cervical schwannomas. Moreover, a brief review of the literature was conducted.  相似文献   
415.
目的:探讨后路椎板切除入路手术治疗椎管内神经鞘瘤的临床疗效。方法:我院2005年1月~2011年1月收治71例椎管内神经鞘瘤,男39例,女32例,年龄25~99岁,平均51.6岁;颈段22例,胸段24例,腰、骶段25例,3例肿瘤位于髓内,66例位于髓外硬膜下,2例位于硬膜外。均行后路椎板切除入路手术治疗,术中57例采用半椎板切除,6例行全椎板切除,2例行多节段半椎板切除,6例行半椎板联合患侧关节突关节切除以完全暴露肿瘤组织,切除肿瘤;其中载瘤神经根与肿瘤无法分离而一并切除者9例;14例行全椎板切除或多节段半椎板切除或半椎板联合患侧关节突切除者采用脊柱内固定及植骨融合术。术后随访8~70个月,观察临床疗效,复查X线片观察脊柱稳定性及植骨融合情况,复查MRI观察肿瘤有无复发。结果:手术时间2~6h,平均3.5h;术中出血量300~800ml,平均450ml。71例患者肿瘤均获完全切除,术后均经病理检查证实为神经鞘瘤。术中无脊髓神经损伤。术后12例患者出现不同程度脑脊液漏,4例患者出现脊髓缺血再灌注损伤,给予对症治疗后康复。随访期内(8~70个月)全部患者临床症状及神经功能均有明显改善,复查MRI未见肿瘤残留或复发。14例采用脊柱内固定及植骨融合术患者植骨融合,内固定稳定。随访期间所有患者未见椎体滑脱、失稳现象。结论:后路椎板切除入路能充分暴露肿瘤,有利于完全切除肿瘤,采用此入路手术治疗椎管内神经鞘瘤临床疗效满意。  相似文献   
416.
目的探讨经小切口局部椎板减压,椎板间插装融合(interlaminar lumbar instrumented fusion,ILIF)技术治疗腰椎管狭窄症的近期疗效。方法 2009年11月-2011年1月,采用经小切口椎板减压、ILIF治疗16例腰椎管狭窄症患者。男7例,女9例;年龄49~67岁,平均52.8岁。病程2年~9年4个月,平均4年7个月。16例均为退变性狭窄,4例合并双侧侧隐窝狭窄,3例合并腰椎间盘突出。病变节段:L3、42例,L4、54例,L5、S14例,L3、4和L4、5双节段2例,L4、5和L5、S1双节段4例。手术前后采用疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)进行临床疗效评定;CT扫描并测量椎管横截面面积。结果手术时间35~80 min,平均47 min;术中出血量120~350 mL,平均145 mL;住院时间4~15 d,平均7.8 d。除1例发生脑脊液漏,其余切口均Ⅰ期愈合。16例均获随访,随访时间12~22个月,平均14.8个月。术后CT扫描固定节段,示14例棘突间融合,2例可能融合;融合时间3~10个月,平均4.6个月。术后VAS评分、ODI及椎管横截面面积均较术前显著改善,差异有统计学意义(P<0.05)。结论 ILIF可兼顾椎板减压和重建后柱稳定性,同时保护脊髓,具有创伤小及操作简便的优点。  相似文献   
417.
目的 探讨胸椎黄韧带骨化症的发病机制及手术方法.方法 回顾性分析经手术治疗的56例胸椎黄韧带骨化症患者的影像学与临床资料.所有患者采用全椎板切除加后外侧融合术,全椎板切除方法包括整块全椎板切除术与椎板分解切除术;手术疗效采用日本骨科协会(JOA)评分法进行评价.结果 56例患者共累及237个节段,以下胸段最为多见,占57.4%(136/237).术后随访18 ~70(25.00±11.56)个月.根据最后一次随访结果,56例患者中优25例,良20例,无变化6例,差5例,优良率80.4%(45/56).根据骨化巢形态,各型手术优良率分别为外侧型83.3%(5/6)、弥漫型82.4%(14/17)、厚结节型78.8%( 26/33).应用整块全椎板切除术24例,其中4例厚结节型中有2例术后脊髓损伤加重;应用椎板分解切除术32例,其中29例厚结节型中仅2例术后脊髓损伤加重.结论 局部应力因素是胸椎黄韧带骨化形成的主要原因之一;全椎板切除加后外侧融合术是治疗本病的理想手术方法,其中外侧型、弥漫型可采用整块全椎板切除术,而厚结节型采用椎板分解切除术更为安全.  相似文献   
418.

Background Context

Despite the fact that ossification of posterior longitudinal ligament (OPLL) is a three-dimensional disease, conventional studies have focused mainly on a two-dimensional measurement, and it is difficult to accurately determine the volume of OPLL growth and analyze the factors affecting OPLL growth after posterior decompression (laminoplasty or laminectomy and fusion).

Purpose

The present study aimed to investigate the factors affecting OPLL volume growth using a three-dimensional measurement.

Study Design/Setting

This was a retrospective case study.

Patient Sample

Eighty-three patients with cervical OPLL who were diagnosed as having multilevel cervical OPLL of more than three levels on cervical computed tomography (CT) scans were retrospectively reviewed from June 1, 1998, to December 31, 2015.

Outcome Measures

The OPLL volume from the C1 vertebrae to the C7 vertebrae was measured on preoperative and the most recent follow-up CT scans.

Methods

Eighty-three patients were retrospectively examined for age, gender, body mass index, hypertension, diabetes, type of OPLL, surgical method, preoperative cervical curvature, and preoperative and postoperative cervical range of motion. Preoperative cervical CT and the most recent follow-up cervical CT scans were converted to Digital Imaging and Communications in Medicine data, and the OPLL volume was three-dimensionally measured using the Mimics program (Materialise, Leuven, Belgium). The OPLL volume growth was analyzed using univariate and multivariate analyses.

Results

The average follow-up period was 32.36 (±23.39) months. Patients' mean age was 54.92 (±8.21) years. In univariate analysis, younger age (p=.037) and laminoplasty (p=.012) were significantly associated with a higher mean annual growth rate of OPLL (%/y). In multivariate analysis, only laminoplasty (p=.027) was significantly associated with a higher mean annual growth rate of OPLL (%/y). The mean annual growth rate of OPLL was about seven times faster with laminoplasty (8.00±13.06%/y) than with laminectomy and fusion (1.16±9.23%/y).

Conclusions

Posterior instrumented fusion has the effect of reducing OPLL growth rate compared with motion-preserving laminoplasty. Patients' age and the surgical method need to be considered in surgically managing the multilevel OPLL.  相似文献   
419.

Background Context

The incidence of postoperative complications after microendoscopic laminectomy (MEL) has not been compared with that after open laminectomy in a large study, so it is not clear whether MEL is a safer procedure.

Purpose

The objective of this study was to compare postoperative morbidity and mortality following lumbar laminectomy between patients treated with MEL and with open laminectomy.

Study Design

This is a retrospective cohort study with propensity score-matched analysis.

Patient Sample

Data of patients who underwent elective spinal surgery between July 2010 and March 2013 were extracted from the Diagnosis Procedure Combination database, a nationwide inpatient database in Japan.

Outcome Measures

Clinical outcomes included length of hospital stay, occurrence of major complications (cardiac events, respiratory complications, pulmonary embolism, stroke, and acute renal failure), surgical site infection (SSI), postoperative delirium, and in-hospital death.

Materials and Methods

Propensity score matching was performed to adjust for measured confounding factors, including patient age, sex, Charlson Comorbidity Index, body mass index, smoking status, blood transfusion, duration of anesthesia, number of operated disc levels, and type of hospital and hospital volumes. The clinical outcomes of one-to-one propensity-matched pairs of the MEL and the open laminectomy groups were compared.

Results

Of 23,317 patients identified in the database, 1,536 underwent MEL (6.6%). By one-to-one propensity score matching, 1,536 pairs were selected. The distributions of patient backgrounds were closely balanced between the MEL and the open laminectomy groups. An analysis of 1,536 pairs revealed that there was a significantly lower incidence of major postoperative complications in those who underwent MEL (1.0% vs. 2.8% for open laminectomy, risk difference 1.8%, 95% confidence interval [CI] 0.9%–2.9%), SSI (0.5% vs. 1.6% for open laminectomy, risk difference 1.1%, 95% CI 0.4%–1.9%), and postoperative delirium (1.1% vs. 2.3% for open laminectomy, risk difference1.2%, 95% CI 0.3%–2.1%). The length of hospital stay was significantly shorter in those treated with MEL (12 days vs. 16 days for open laminectomy, p<.001). There was no significant difference in in-hospital mortality between the groups.

Conclusions

Patients who underwent MEL were significantly less likely to experience major postoperative complications and were less likely to develop SSI and postoperative delirium than those who underwent open laminectomy.  相似文献   
420.
应用人工硬脊膜预防瘢痕粘连早期临床观察   总被引:2,自引:4,他引:2  
目的:介绍一种新的预防脊柱外科手术后瘢痕组织形成,硬膜粘连的一种方法,提高对椎板切除术后硬膜粘连的认识。方法:对17例腰椎间盘突出症椎板间开窗、间盘摘除的病人,术中应用美国戈尔公司生产的人造硬脊膜,术后3—6个月行核磁共振检查瘢痕组织的生成与硬膜粘连的情况。结果:17例应用人造硬脊膜的病人,3—6个月核磁共振示人造硬脊膜与脊髓之间无粘连,无瘢痕组织长入硬脊膜外空间,而同期手术的14例病人末应用此人工材料,其核磁共振影像均可见不同程度的瘢痕组织增生,脊髓与瘢痕组织粘连,神经根周围亦有瘢痕组织包裹、环绕。结论:人造硬脊膜有效降低了椎板切除术后瘢痕组织的产生程度,使病人减少了椎板切除术后瘢痕组织生成导致的疼痛,亦为二次手术创造了有利的条件。人造硬脊膜是一种比较理想的隔离物。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号