冬季护肤百分百

严寒的冬天,人们的身体受到寒冷气候的影响,新陈代谢开始减慢,皮肤分泌汗腺,皮脂腺随之减少,皮肤因此逐渐失去光泽,加之冬季空气湿度变小,风多,导致皮肤水分流失过多,皮肤易干燥、刺痛、瘙痒,面部易增皱纹,嘴唇易干燥、脱皮,手脚皮肤易变得粗糙或裂口等。怎样才能避免这些烦恼,让皮肤锁住水分,光彩依旧呢?     

Comparison Study on Clinical and Neuropathological Characteristics of Hamsters Inoculated With Scraple Strain 263K in Different Challenging Pathways

OBJECTIVE: To understand the infectious characteristics of a hamster-adapted scrapie strain 263K with five different routes of infection including intracerebral (i.c.), intraperitoneal (i.p.), intragastrical (i.g.), intracardiac and intramuscular (i.m.) approaches. METHODS: Hamsters were infected with crude- or fine-prepared brain extracts. The neuropathological changes, PrP(Sc) deposits, and patterns of PK-resistant PrP were analyzed by HE stain, immnunohistochemistry (IHC) assay and Western blot. Reactive gliosis and neuron loss were evaluated by glial fibrillary acidic protein (GFAP) and neuron specific enolase (NSE) specific IHC. RESULTS: The animals inoculated in i.m. and i.p. ways with crude PrP(Sc) extracts showed clinical signs at the average incubation of 69.2 +/- 2.8 and 65.5 +/- 3.9 days. Inoculation in i.c. and intracardiac ways with fine PrP(Sc) extracts (0.00035 g) caused similar, but relative long incubation of around 90 days. Only one out of eight hamsters challenged in i.g. way with low dosage (0.01 g) became ill after a much longer incubation (185 d), while all animals (4/4) with high dosage (0.04 g) developed clinical signs 105 days postinfection. The most remarkable spongiform degeneration and PrP(Sc) deposits were found in brain stem among the five challenge groups generally. The number of GFAP-positive astrocytes increased distinctly in brain stems in all infection groups, while the number of NSE-positive cells decreased significantly in cerebrum, except i.c. group. The patterns of PK-resistant PrP in brains were basically identical among the five infection routes. CONCLUSION: Typical TSE could be induced in hamsters by inoculating strain 263K in the five infection ways. The incubation periods in bioassays depend on infective dosage, administrating pathway and preparation of PrP(Sc). The neuropathological changes and PrP(Sc) deposits seem to be related with regions and inoculating pathways.     

睫毛耻阴虱1例

男，25岁，左眼睑瘙痒伴异物感8d于2004-06-28就诊，患8d前不明原因出现左眼上睑瘙痒，伴虫行异物感．眼部余无不适。追诉患2nm前有不洁性接触史，且外阴瘙痒至今。检查：双眼视光1．0．左上睑缘皮肤点状充血，可见散在细小丘疹、血痂，睫毛上见直径0．5～10mm大小呈淡白色椭圆形虫卵10余粒，有2粒已孵化，20倍裂隙灯显微镜下见睑正中睫毛体和根部各见一长1．5mm、宽1．0mm的蟹样虫体，镜下缓慢移动，     

瘙痒有病灶 切莫不追究

瘙痒是一种很不愉快的感觉，但不少人很少追究瘙痒的原因。这里提醒读者，相当一部分瘙痒可能是某种严重疾病的“信号”。     

抗过敏药也能引起过敏反应

一名女青年因全身瘙痒，医生给她开了扑尔敏，嘱其一日3次，一次1片。当晚，她的瘙痒症状非但没有减轻，反而加重了，背部出现红斑及水泡，两天后遍及全身，并出现畏寒、高热，被诊断为大疱性表皮松解型药疹。后来做扑尔敏皮内试验为阳性，证实此疾病由扑尔敏过敏引起的。     

高原藏族肛门瘙痒患者的真菌检测

我院地处西藏高原 ,海拔 2 75 0米 ,主要特点是低氧、气压低、寒冷、干燥 ,在此特殊环境下 ,我们对藏族患者真菌与腊门瘙痒症的关系以及比特力口服配合派瑞松软膏外搽的疗效作了初步观察。1　材料与方法1 1　一般资料选择 2 0 0 0年 2月至 2 0 0 4年 2月因肛门瘙痒来诊的藏族患     

早期妊娠合并滴虫性阴道炎中药治疗效果观察

1995年5月～1998年5月我院对200例早期妊娠合并滴虫性阴道炎以中药熏洗治疗，年龄在22～30岁，妊娠均在12周内。患者均伴有不同程度的白带增多，外阴瘙痒，分泌物呈黄色或黄绿色，质稀薄泡沫状，有臭味，阴道分泌物涂片检查均见滴虫存在。     

消风止痒胶囊治疗瘙痒性皮肤病临床研究

目的观察院内制剂消风止痒胶囊对瘙痒性皮肤病的疗效.方法将患者分为观察组和对照组,观察组予消风止痒胶囊,对照组予息斯敏.结果观察组疗效优于对照组,且除对慢性湿疹和辨证属风寒束表者外,疗效均较为满意.结论消风止痒胶囊对瘙痒性皮肤病疗效可靠.     

奇症验案二则

刘某，女，63岁，1997年9月8日初诊。3个月前由于楼上邻居装修房屋使用防水油膏给厕所补漏，防水油膏顺管道渗漏而下，闻及气味则出现气急皮肤紧绷等症状。2个月前因气温较高，防水油膏气味弥漫，出现全身奇痒，到市人民医院诊断为过敏性口炎、鼻炎、角膜炎、胃肠炎、皮炎等，经住院输液3天后病情缓解。     

聚焦超声联合地米硼酸乳膏治疗慢性局限性瘙痒性皮肤病的疗效及患者生活质量评价

目的分析聚焦超声联合地米硼酸乳膏治疗慢性局限性瘙痒性皮肤病的疗效以及对患者生活质量的影响,为开展相关治疗提供参考。方法随机选取慢性局限性瘙痒性皮肤病患者126例,根据病种、病程及皮损情况,按就诊顺序随机分为治疗组和对照组各63例,治疗组给予聚焦超声治疗,每2周1次,期间给予地米硼酸乳膏外用治疗,每日2次,对照组仅给予地硼霜外用治疗,每日2次。在治疗前和开始治疗12周后记录患者症状体征评分和皮肤病生活质量评分表,对患者疗效及生活质量影响进行评价。结果治疗组和对照组治疗有效率分别为92. 06%和42. 86%,差异有统计学意义(X~2=34. 745,P<0. 05),两组患者生活质量均有改善,改善程度有统计学差异(t=-12. 468,P<0. 05)。结论聚焦超声联合地米硼酸乳膏治疗慢性局限性瘙痒性皮肤病安全、有效,提高患者生活质量评分。