排序方式: 共有75条查询结果,搜索用时 31 毫秒
41.
武海军 《临床合理用药杂志》2010,3(11):49-49
为考察我院是否存在不合理用药问题,笔者抽取住院病历20份,门诊处方3283张进行调查分析。经查阅有关文献资料,现将一些用药不当问题报道如下。 相似文献
42.
紫花高乌头总碱对吗啡依赖大鼠氯唑沙宗药动学的影响 总被引:3,自引:0,他引:3
目的:观察紫花高乌头总碱对吗啡依赖大鼠氯唑沙宗药动学的影响。方法:采用剂量递增法复制吗啡依赖大鼠模型,注射纳洛酮催促产生戒断症状,高效液相色谱法测定经CYP2E1代谢的探针药物氯唑沙宗血药浓度经时变化。结果:吗啡依赖可致大鼠CYP2E1对探针药物氯唑沙宗的代谢活性增强,AUC减少,Cmax减少。催促戒断可致体质量减轻,CYP2E1对探针药物氯唑沙宗的代谢活性进一步增强。紫花高乌头总碱可降低大鼠的戒断反应症状分值,控制大鼠的体质量下降,下调吗啡依赖所致的CYP2E1的代谢活性增强。结论:紫花高乌头总碱可抑制吗啡依赖大鼠的戒断症状,使吗啡依赖及其催促戒断后增高的CYP2E1代谢活力下调。 相似文献
43.
44.
45.
46.
目的:比较不同程度睡眠呼吸障碍患者黄斑区神经节细胞复合体(GCC)的厚度变化。方法:采用横断面研究,收集2015-06/2018-06间于我校附属医院诊断为阻塞性睡眠呼吸障碍综合征的患者和健康体检者,将呼吸暂停低通气指数(AHI)≥5的58例患者纳入睡眠呼吸障碍组,根据AHI值将其分为轻、中、重度三个亚组,将AHI<5的50例健康体检者纳入对照组。采用RTVUE 100-2型相干光断层扫描检查仪对黄斑区视网膜进行扫描,测量黄斑区GCC总体平均厚度(GCC-Avg)、上方平均厚度(GCC-Sup)、下方平均厚度(GCC-Inf)、局部丢失容积(FLV)与整体丢失容积(GLV)。分析比较各组间GCC厚度的差异。结果:不同程度睡眠呼吸障碍组各区GCC厚度均较对照组变薄(P<0.05),但FLV和GLV均较对照组增加(P<0.05),不同程度睡眠呼吸障碍组组间FLV比较无差异(P>0.05),不同程度睡眠呼吸障碍组组间GLV比较有差异(P<0.05)。结论:随着睡眠呼吸障碍程度的加重黄斑区GCC厚度变薄。 相似文献
47.
48.
49.
BACKGROUND:Mesenchymal stem cells (MSCs) for the treatment of degenerative disc diseases present a new therapeutic strategy for the structural and functional recovery of the degenerative intervertebral disc.
OBJECTIVE:To study the differentiation potential of rabbit bone marrow MSCs (BMSCs) into nucleus pulposus-like cells.
METHODS:Passage 3 BMSCs and nucleus pulosus cells (NPCs) extracted from rabbits were assigned into simple BMSCs culture, simple NPCs culture or co-culture group. In the former two groups, BMSCs or NPCs were cultured in 6-well culture plates. In the co-culture group, passage 3 BMSCs and NPCs were cultured on the upper or lower layer of the 6-well Transwell chamber, respectively. Cell morphology was observed by inverted contrast phase microscope. At 7 days of culture, immunocytochemistry, RT-PCR and western blot were used to examine the expression levels of type II collagen and aggrecan.
RESULTS AND CONCLUSION:At 7 days of co-culture, BMSCs were polygonal or short spindle-shaped, with no fiber-like changes, and cell morphology was close to that of NPCs. Additionally, the expression levels of type II collagen and aggrecan in the BMSCs co-cultured with NPCs were similar to those in the NPCs cultured alone, but significantly higher than those in the BMSCs culture only. Overall, these results show that coculture of BMSCs with NPCs can induce BMSCs differentiating into an NPCs phenotype, indicating that BMSCs may provide sufficient sources of cells for the biological treatment of degenerative disc diseases. 相似文献
50.
目的:探讨姜黄素对碱烧伤角膜新生血管(corneal neovascularization,CNV)和房水VEGF表达的影响。方法:新西兰大耳白兔23只分为正常组A组3只,实验对照组B组20只左眼,实验干预组C组20只右眼。建立兔角膜碱烧伤CNV模型,运用裂隙灯观察CNV生长及用病理组织切片、酶联免疫吸附试验分别检测应用姜黄素前后角膜微血管计数和VEGF在兔房水中的表达情况。结果:正常组没有CNV生成,C组和B组相比CNV的生长受到明显抑制,二者微血管计数差异具有显著性(B组vsC组,P<0.05)。房水VEGF在3组中均有表达,但是B组和C组明显高于A组(B组vsA组、C组vsA组,两者均P<0.05),C组的VEGF表达低于B组,差异均有显著性(B组vsC组,P<0.05)。结论:姜黄素可有效降低角膜碱烧伤后房水VEGF的表达并使CNV数目减少。 相似文献