过夜配戴角膜矫形镜早期并发症分析

目的观察过夜配戴角膜矫形镜（0K镜）的并发症，探讨发生原因及处理方法。方法采用OK镜治疗的患者95例182眼，通过视力、屈光、眼压、裂隙灯及角膜地形图等检查并记录患者主诉，观察及分析并发症发生情况。结果本组患者在治疗过程中发生的主要并发症有角膜上皮脱落51眼（28．02％），不适感35眼（19．23％），视力不稳定25眼（13．74％），叠影20眼（10．99％），眩光13眼（7．14％）等。结论OK镜虽可有效减低近视屈光度，提高远视力，但对治疗过程中出现的并发症应予以重视。     

心脏三维标测中配准方法的研究

目的对标测导管采集点与计算机断层（CT）或核磁共振（MR）成像建立的三维心脏模型进行配准。方法现有的方法通常是以三维标测点空间和CT/MR数据模型空间都是正交为前提,因此这些方法通常只调整三维平移、旋转和拉伸等9个自由度来实现配准。而我们的研究表明,这2个空间不一定同时正交。因此引入了基于12个自由度的仿射变换模型和相应的迭代最近点算法来实现配准,并研究了如何把该算法与手术操作结合起来。结合OpenGL,我们用Visual C＋＋ 6.0软件实现了该配准方法。结果仿真结果表明：平均误差由配准前的40像素降到了配准后的1.5像素;进一步的动物实验验证了该算法的有效性。结论本文提出的三维标测配准算法能够实现心脏三维标测中的配准。     

Impaired attention network in temporal lobe epilepsy: A resting FMRI study

Attention deficit is a common symptom in the patient with mesial temporal lobe epilepsy (mTLE). Although presumption has been proposed by the previous study that mTLE may have impaired attention networks, no fMRI study has addressed the alteration of the dorsal attention network in mTLE. Twenty-four patients with bilateral mTLE and the same number of gender- and age-matched healthy controls participated in the current fMRI study. The resting-state network corresponding to the dorsal attention network (DAN) was extracted by using independent component analysis (ICA) from each participant. Functional connectivity in the DAN was then compared between the patients and controls. In addition, the scores of Trail Making Test (TMT) in the patients were correlated to the z-score of the voxels showing significant difference between the two groups. Compared with the controls, the patients with mTLE presented decreased functional connectivity in almost all the regions within the DAN. Moreover, there were negative correlations between the TMT scores and the z-scores in the voxels showing decreased or increased functional connectivity in mTLE. Our results suggested that the alteration of DAN might underpin the impairment of top-down attention function in mTLE. Our fMRI study may contribute to the understanding of neuro-pathophysiological mechanism of attention impairments in patients with mTLE.     

Cortico-limbic response to personally challenging emotional stimuli after complete recovery from depression

People vulnerable to depression are at increased risk of relapse if they live in highly critical family environments. To explore this link, we used neuroimaging methods to examine cortico-limbic responding to personal criticisms in healthy participants and participants with known vulnerability to major depression. Healthy controls and fully recovered participants with a past history of major depression were scanned while they heard praising, critical, and neutral comments from their own mothers. Prior to scanning, the formerly depressed and the control participants were indistinguishable with respect to self-reported positive, negative, or anxious mood. They also reported similar mood changes after being praised or criticized. However, formerly depressed participants responded to criticism with greater activation in the amygdala and less activation in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) than did controls. During praise and neutral commentary, amygdala activation was comparable in both groups, although lower levels of activation in the DLPFC and ACC still characterized formerly depressed participants. Vulnerability to depression may be associated with abnormalities in cortico-limbic activation that are independent of mood state and that remain even after full recovery. Criticism may be a risk factor for relapse because it activates the amygdala and perturbs the affective circuitry that underlies depression.     

Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide

Both major depressive disorder and bipolar disorder are the subject of a voluminous imaging and genetics literature. Here, we attempt a comprehensive review of MRI and metabolic PET studies conducted to date on these two disorders, and interpret our findings from the perspective of developmental and degenerative models of illness. Elevated activity and volume loss of the hippocampus, orbital and ventral prefrontal cortex are recurrent themes in the literature. In contrast, dorsal aspects of the PFC tend to display hypometabolism. Ventriculomegaly and white matter hyperintensities are intimately associated with depression in elderly populations and likely have a vascular origin. Important confounding influences are medication, phenotypic and genetic heterogeneity, and technological limitations. We suggest that environmental stress and genetic risk variants interact with each other in a complex manner to alter neural circuitry and precipitate illness. Imaging genetic approaches hold out promise for advancing our understanding of affective illness.     

角膜异物剔除术236例的临床观察

目的探讨角膜异物的预防和治疗。方法采取不同的治疗措施剔除异物。结果236例中一次取净196例（83％）,其余复诊时取净。结论角膜异物应尽吊采取措施取除异物,其疗效可靠,不良反应更少。     

基于XML技术的电子病历管理平台研究与实现

介绍电子病历的内涵与发展历程,阐述基于XML技术电子病历管理平台构建的意义、功能及实现方案,从基于XML的电子病历建模,支持HL7、DICOM和XML集成医疗网关,基于SOA、多标准兼容集成网关的系统架构几方面介绍平台的具体实现技术。     

心肌力学量化评价技术现状及研究进展

心脏的心肌组织体积占心脏总体积的95%以上。毫无疑问,任何心脏疾病的发生和发展均将对心肌组织产生不同程度的损伤。而组织结构的损伤必将导致心肌力学功能的异常。如何早期检出并全面描述心肌的结构功能损伤是临床早期发现和诊断心肌病变的关键。本文就现有的心肌力学影像学评价技术的研究现状及研究方向作一述评。