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101.
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Yuqiao Diao Ping Zhang Ruoheng Dai Jianfa Xu Helin Feng 《Pathology, research and practice》2018,214(7):974-977
Purpose
Previous studies have shown a correlation between the expression of H3K27me3 and pathological characteristics of malignant tumors. This study aimed to investigate the association of H3K27me3 and VEGF expression with clinical outcomes of synovial sarcoma patients.Methods
This study included 48 patients with synovial sarcoma. H3K27me3 and VEGF levels were evaluated by immunohistochemical staining, and their correlation with clinical parameters was analyzed by Spearman’s and Pearson’s test. Univariate and multivariate Cox regression analyses were used to identify potential prognostic factors. Kaplan-Meier method was used to analyze overall survival.Results
Protein levels of both H3K27me3 and VEGF were significantly associated with histologic grade (P?=?0.004, P?=?0.042, respectively), metastasis (P?=?0.009, P?=?0.028, respectively), and AJCC staging (P?<?0.001, P?=?0.003, respectively). H3K27me3 and VEGF expression showed positive correlation (P?<?0.001, R?=?0.618). Both H3K27me3 and VEGF expression were significantly associated with shorter overall survival by univariate analysis, but the association was significant for H3K27me3 [P?=?0.26, HR?=?2.640 (1.124–6.200)] only by multivariate analysis.Conclusions
H3K27me3 and VEGF expression are both significantly associated with overall survival of synovial sarcoma, and H3K27me3 is a significant independent prognostic indicator in patients with synovial sarcoma. 相似文献103.
Soluble B7‐H4 blood serum levels are elevated in women at high risk for preeclampsia in the first trimester,as well as in patients with confirmed preeclampsia 下载免费PDF全文
Pawel Mach Luisa Nolte‐Boenigk Leonie Droste Laura Fox Mirjam Frank Boerge Schmidt Florian Herse Stefan Verlohren Lukasz Wicherek Antonella Iannaccone Cahit Birdir Dimitrios Andrikos Rainer Kimmig Alexandra Gellhaus Angela Köninger 《American journal of reproductive immunology (New York, N.Y. : 1989)》2018,80(3)
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Lyne Gagnon Martin Leduc Jean-Francois Thibodeau Ming-Zhi Zhang Brigitte Grouix Francois Sarra-Bournet William Gagnon Kathy Hince Mikaël Tremblay Lilianne Geerts Christopher R.J. Kennedy Richard L. Hébert Alex Gutsol Chet E. Holterman Eldjonai Kamto Liette Gervais Jugurtha Ouboudinar Jonathan Richard Pierre Laurin 《The American journal of pathology》2018,188(5):1132-1148
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Franco H. Falcone Daniel Wan Nafal Barwary Ronit Sagi-Eisenberg 《Immunological reviews》2018,282(1):47-57
Since their establishment in 1981, RBL-2H3 cells have been widely used as a mast cell (MC) model. Their ability to be easily grown in culture in large amounts, their responsiveness to FcεRI-mediated triggers and the fact that they can be genetically manipulated, have provided advantages over primary MCs, in particular for molecular studies relying on genetic screening. Furthermore, the ability to generate clones that stably express proteins of interest, for example, a human receptor, have marked the RBL cells as an attractive MC model for drug screening. Indeed, 3 RBL reporter cell lines (RS-ATL8, NFAT-DsRed, and NPY-mRFP) have been generated providing useful models for drug and allergen screening. Similarly, RBL cells stably expressing the human MrgprX2 receptor provide a unique paradigm for analyzing ligand interactions and signaling pathways of the unique human receptor. Finally, transient co-transfections of RBL cells allow functional genomic analyses of MC secretion by combining library screening with simultaneous expression of a reporter for exocytosis. RBL cells thus comprise powerful tools for the study of intracellular membrane trafficking and exocytosis and the detection of allergens, vaccine safety studies and diagnosis of allergic sensitization. Their recent uses as an investigative tool are reviewed here. 相似文献
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