小鼠诺瓦克病毒研究现状

诺瓦克病毒（Norwalk virus,NV）,也称为诺如病毒（norovirus,NV）,是引起人类非细菌性胃肠炎的主要病原体,此外,在牛、猪和小鼠也发现了诺瓦克病毒的存在.该病毒可分5个基因型（GⅠ～Ⅴ）,鼠诺瓦克病毒（Murine norovirus,MNV）属于GV,是一种新发现的感染实验小鼠的病毒,并且被认为是目前小鼠中最流行的一种病毒.MNV是诺瓦克病毒中在细胞内有效复制的病毒,被作为研究诺瓦克病毒复制分子机制的模型,同时MNV与人诺瓦克病毒（Human noroviruses,HuNV）有许多相似的分子生物学特点,也被认为是研究人诺瓦克病毒的理想病毒模型.     

Viruses, autophagy genes, and Crohn's disease

The etiology of the intestinal disease Crohn's disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn's disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.