加巴喷丁与卡马西平治疗复发性三叉神经痛的临床效果分析

目的分析加巴喷丁与卡马西平治疗复发性三叉神经痛的临床效果。方法将2016年1月~2017年8月于本院进行治疗的60例复发性三叉神经痛患者作为研究对象,回顾性分析该60例患者的病历资料,按照治疗方式的不同将患者分成两组,普通组使用卡马西平进行治疗,实验组采用加巴喷丁进行治疗,对比分析两组患者的治疗效果。结果治疗后,实验组患者的VAS评分为(2.5±0.5)分,LSI-B指数为(16.5±2.1),各项指标均优于普通组(P0.05);实验组患者的治疗有效率为93.33%,不良反应发生率为3.33%,两项数据均优于普通组(P0.05)。结论加巴喷丁治疗复发性三叉神经痛的效果明显优于卡马西平,该药可有效缓解患者疼痛,且药物不良反应更少,用药安全可靠,能够显著提升患者的生活质量,应在复发性三叉神经痛的治疗中优先选用。     

The retrospective study for effectiveness of cervical cerclage in preventing recurrent preterm birth

ObjectiveThis study aimed to clarify the effectiveness of cervical cerclage in preventing recurrent preterm births.Materials and methodsA retrospective study was conducted using the perinatal registration database of the Japan Society of Obstetrics and Gynecology for the Perinatal Center from 2014 to 2016. The efficacies of history-indicated, ultrasound-indicated, and physical examination-indicated cerclage as preventive treatments for women with a history of preterm birth were evaluated by comparing cerclage and non-cerclage cases. Fisher's exact test was performed to evaluate any significant differences in patient backgrounds. Prior to the evaluation, propensity score matching was performed for history-indicated and ultrasound-indicated cerclage patients.ResultsFor this study, 6060 multiparous women with a history of preterm birth were reviewed. After excluding 17 patients with unknown indications for cervical cerclage, 6043 patients were included in the study. History-indicated and ultrasound-indicated cerclage did not reduce the risk of preterm birth in subsequent pregnancies for any of the pregnancy periods (p = 0.413, p = 1.000). In contrast, physical examination-indicated cerclage significantly reduced the risk of subsequent preterm births for all pregnancy periods (p < 0.001).ConclusionSubsequent preterm births were effectively prevented only in physical examination-indicated cerclage cases. For history- or ultrasound-indicated cerclage, statistically significant differences in subsequent preterm births were not evident.     

Polymorphisms in tumor necrosis factor-alpha (−863C>A, −857C>T and +488G>A) are associated with idiopathic recurrent pregnancy loss in Korean women

Polymorphisms in TNF-a have been reported as genetic risk factors for recurrent spontaneous abortion and TNF-α may be immunologically important. We therefore examined the contribution of several TNF-a mutations to this phenomenon. The study participants consisted of 388 patients with idiopathic recurrent pregnancy loss (RPL), which was diagnosed on the basis of at least two consecutive spontaneous abortions; control subjects were 224 healthy women with a history of successful pregnancies. Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to determine the TNF-α −863C>A, −857C>T, and +488G>A genotypes. The TNF-α −863C>A variants correlated with increased risk of RPL (CA + AA; adjusted odds ratio [AOR], 2.142; 95% confidence interval [CI], 1.493–3.074). These data did not differ in a stratified analysis according to number of consecutive spontaneous abortions. In haplotype analysis, there were similar trends of data for combination analysis, but in patients with 3+ pregnancy losses, a stratified analysis revealed that this correlation did not increase directly with the number of pregnancy losses. The TNF-α −863C>A variant is a possible genetic risk factor for idiopathic RPL in Korean women.     

喘可治注射液治疗复感儿反复呼吸道感染的疗效研究

目的通过比较研究,探讨喘可治注射液在治疗小儿反复呼吸道感染的效果。方法从我院2010年10月—2013年10月间接诊的病患中抽取100例患儿,随机分为治疗组和对照组,每组各50例,对照组施行常规治疗,治疗组在常规治疗的基础上联合施行喘可治注射液注射。并进行跟踪随访,一年后观察两组疗效。结果在两组治疗中,治疗组显效率为70%,有效率20%,无效率为10%,总有效率为90%。而对照组的显效病患为15例,显效率为30%,有效病患21例,有效率为42%,无效病患为14例,无效率28%,总有效率为72%。治疗组治疗效果明显好于对照组。结论通过对比研究,我们可以发现在治疗反复呼吸道感染时,喘可治注射液治疗效果好,值得推广使用。