全文获取类型
收费全文 | 94439篇 |
免费 | 8173篇 |
国内免费 | 3990篇 |
专业分类
耳鼻咽喉 | 1010篇 |
儿科学 | 1996篇 |
妇产科学 | 1520篇 |
基础医学 | 11533篇 |
口腔科学 | 4162篇 |
临床医学 | 10015篇 |
内科学 | 9753篇 |
皮肤病学 | 1443篇 |
神经病学 | 3605篇 |
特种医学 | 4875篇 |
外国民族医学 | 58篇 |
外科学 | 12715篇 |
综合类 | 14994篇 |
现状与发展 | 28篇 |
预防医学 | 2586篇 |
眼科学 | 1111篇 |
药学 | 6390篇 |
53篇 | |
中国医学 | 3000篇 |
肿瘤学 | 15755篇 |
出版年
2024年 | 169篇 |
2023年 | 1378篇 |
2022年 | 2049篇 |
2021年 | 3718篇 |
2020年 | 3284篇 |
2019年 | 3015篇 |
2018年 | 2939篇 |
2017年 | 3120篇 |
2016年 | 3422篇 |
2015年 | 3650篇 |
2014年 | 5901篇 |
2013年 | 6862篇 |
2012年 | 5254篇 |
2011年 | 5930篇 |
2010年 | 4730篇 |
2009年 | 4789篇 |
2008年 | 4866篇 |
2007年 | 5148篇 |
2006年 | 4625篇 |
2005年 | 4157篇 |
2004年 | 3596篇 |
2003年 | 3054篇 |
2002年 | 2644篇 |
2001年 | 2375篇 |
2000年 | 1902篇 |
1999年 | 1739篇 |
1998年 | 1453篇 |
1997年 | 1369篇 |
1996年 | 1201篇 |
1995年 | 1080篇 |
1994年 | 916篇 |
1993年 | 717篇 |
1992年 | 651篇 |
1991年 | 568篇 |
1990年 | 460篇 |
1989年 | 434篇 |
1988年 | 422篇 |
1987年 | 360篇 |
1986年 | 288篇 |
1985年 | 378篇 |
1984年 | 326篇 |
1983年 | 217篇 |
1982年 | 280篇 |
1981年 | 262篇 |
1980年 | 205篇 |
1979年 | 170篇 |
1978年 | 132篇 |
1977年 | 99篇 |
1976年 | 113篇 |
1975年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
71.
《药学学报(英文版)》2020,10(7):1294-1308
A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations. Inspired by our previous efforts in designing antitumor evodiamine derivatives, herein selective histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) dual inhibitors were successfully identified, which showed potent in vitro and in vivo antitumor potency. Particularly, compound 30a was orally active and possessed excellent in vivo antitumor activity in the HCT116 xenograft model (TGI = 75.2%, 150 mg/kg, p.o.) without significant toxicity, which was more potent than HDAC inhibitor vorinostat, TOP inhibitor evodiamine and their combination. Taken together, this study highlights the therapeutic advantages of evodiamine-based HDAC1/TOP2 dual inhibitors and provides valuable leads for the development of novel multi-targeting antitumor agents. 相似文献
72.
73.
Taisuke Inada Satoshi Fukushima Masayuki Murai Masatoshi Jinnin Azusa Miyashita Satoshi Nakahara Junji Yamashita Jun Aoi Shinichi Masuguchi Hironobu Ihn 《The Journal of dermatology》2015,42(2):198-201
miRNA‐221 (miR‐221) is known to be abnormally expressed in many human cancers. The serum levels of miR‐221 have been reported as a tumor marker for malignant melanoma (MM). We hypothesized that the hair shaft miR‐221 levels may be increased in patients with MM. We therefore assessed the possibility that hair shaft miR‐221 levels could be a marker for MM. The hair shaft miR‐221 levels were significantly higher in patients with MM than controls. The rates of increased hair shaft miR‐221 levels above the cut‐off value were comparable to those of serum 5‐S‐CD, which is a tumor marker commonly used for MM. Measurements of the hair shaft miR‐221 levels could have potential clinical value in the detection of MM. This is the first report investigating the hair shaft levels of an miRNA in patients with MM. Our investigations offer new insight into the relationship between miR‐221 and MM, and may provide a new, non‐invasive way to screen for melanoma. 相似文献
74.
75.
John Lennon Silva Cunha Amanda Almeida Leite Thamiris de Castro Abrantes Lorena Passoni Vervloet Thayn Melo de Lima Morais Gerson de Oliveira Paiva Neto Tatiana Nayara Librio Kimura Snia Maria Soares Ferreira Ricardo Luiz Cavalcanti de Albuquerque‐Júnior Aline Corrêa Abraho Mario Jos Romaach Bruno Augusto Benevenuto de Andrade Oslei Paes de Almeida Ciro Dantas Soares 《Journal of cutaneous pathology》2021,48(1):24-33
76.
Antoine Lin Hlne Sudour‐Bonnange Virginie Languillat‐Fouquet Herv Brisse Sabine Irtan Arnauld Verschuur Sabine Sarnacki Estelle Thbaud Aurore Coulomb‐L'Hermine Anne Notz‐Carrre Jean Michon Marie‐Dominique Tabone Ccile Boulanger Isabelle Pellier Claire Freycon Georges Audry Frdrique Dijoud Magali Morelle Christophe Bergeron Claudia Pasqualini 《Pediatric blood & cancer》2020,67(6)
77.
78.
Roberto V.P. Ribeiro Mitesh V. Badiwala Danny Ramzy Laura C. Tumiati Vivek Rao 《The Journal of thoracic and cardiovascular surgery》2019,157(2):615-625.e1
Objective
Hypertonic saline (HTS) has potent immune and vascular effects. We assessed recipient pretreatment with HTS on allograft function in a porcine model of heart transplantation and hypothesized that HTS infusion would limit endothelial and left ventricular (LV) dysfunction following transplantation.Methods
Heart transplants were performed after 6 hours of cold ischemic storage. Recipient pigs were randomized to treatment with or without HTS (7.5% NaCl) before cardiopulmonary bypass (CPB). Using a myograft apparatus, coronary artery endothelial-dependent (Edep) and -independent (Eind) relaxation was assessed. LV performance was determined using pressure-volume loop analysis. Pulmonary interleukin (IL)-2, IL-6, and tumor necrosis factor (TNF)-α expression was measured.Results
Weaning from CPB and LV performance after transplantation were improved in HTS-treated animals. Successful weaning from CPB was greater in the HTS-treated hearts (8 of 8 vs 2 of 8; P < .05). Mean LV functional recovery was improved in the HTS-treated animals, as assessed by preload recruitable stroke work (65 ± 10% vs 27 ± 10%; P < .001) and end-systolic elastance (55 ± 7% vs 37 ± 4%; P < .001). Treatment with HTS resulted in improved Edep (mean maximum elastance [Emax], 56 ± 5% vs 37 ± 7%; P < .001) and Eind (mean Emax%, 77 ± 6% vs 52 ± 4%; P < .001) vasorelaxation compared with control. Pulmonary expression of IL-2, IL-6, and TNF-α increased following transplantation, whereas HTS therapy attenuated IL production (P < .001). Transplantation increased plasma TNF-α levels and LV TNF-α expression, whereas HTS prevented this up-regulation (P < .001).Conclusions
Recipient HTS pretreatment preserves allograft vasomotor and LV function, and HTS therapy limits CPB-induced injury. HTS may be a novel recipient intervention to prevent graft dysfunction. 相似文献79.
80.
�� ��a������ٻb��������a��������a������������ �� 《中国实用外科杂志》2019,39(2):194-196