奥沙利铂联合羟基喜树碱与氟尿嘧啶及亚叶酸钙治疗晚期胃癌

采用随机分组的方法将 5 4例晚期胃癌患者分为HLFO(艾恒 羟基树碱 亚叶酸钙 氟尿嘧啶 )方案组 2 6例与ELF(依托泊苷 亚叶酸钙 氟尿嘧啶 )方案组 2 8例 ,观察两组的临床疗效和患者的耐受性。治疗组 2 6例有效率 5 7 7% ,对照组 3 9 3 % ,两组差异有统计学意义 ,P <0 0 5。治疗组有独特的周围神经毒性 ,其余不良反应均相似。初步研究结果提示 ,HLFO方案是治疗晚期胃癌有效且毒性较小的联合化疗方案     

MVP方案加或不加光量子血液疗法治疗晚期非小细胞肺癌

目的 :观察MVP方案加光量子血液疗法治疗晚期非小细胞肺癌 (NSCLC)的近期疗效和毒副作用。方法 :将 4 8例晚期NSCLC患者随机分为治疗组和对照组 ,分别接受MVP方案 (丝裂霉素、西艾克、顺铂 )及化疗当日开始光量子血液治疗法或单纯MVP方案化疗。结果 :治疗组部分缓解率 5 4 2 % ,对照组 2 5 0 % (P <0 0 5 ) ,中位缓解期分别为 5 1个月及 4 2个月。治疗组毒性明显小于对照组。结论 :MVP方案化疗同时应用光量子血液疗法治疗晚期NSCLC ,疗效有所提高 ,毒性有所减少。     

A phase II study of carboplatin and paclitaxel in esophageal cancer.

BACKGROUND: This study was conducted to evaluate the efficacy and toxicity of combination carboplatin and paclitaxel in patients with esophageal cancer. MATERIALS AND METHODS: Thirty-five patients were enrolled. Patients were treated with paclitaxel 200 mg/m(2) intravenously (i.v.) over 3 h and carboplatin i.v. at an AUC of 5 mg/h/ml. Thirty-three patients were assessable for toxicity and objective response. RESULTS: A total of 166 treatment courses were administered with a median of five courses per patient. The objective response rate was 43% [90% confidence interval (CI) 0.3-0.58] by the intention-to-treat analysis. The median response duration was 2.8 months (90% CI 2.1-5.4). The median survival time was 9 months (90% CI 7-13.8) and the 1-year survival rate was 43% (90% CI 0.29-0.57). The major grade 3-4 toxicity observed was neutropenia, occurring in 17 patients (52%). There were no treatment-related deaths. CONCLUSIONS: The combination of carboplatin and paclitaxel is an moderately active and tolerable regimen in advanced esophageal cancer.     

艾恒治疗38例晚期实体肿瘤的近期疗效

目的 观察以艾恒为主的联合化疗治疗晚期实体肿瘤的疗效及毒副作用。方法 38例鼻咽癌、食管癌、胃癌、小细胞肺癌、肠癌、卵巢癌患者,应用以艾恒为主联合化疗方案,观察疗效及毒副反应。结果 PR 12例,总有效率为31.6％。主要毒副作用为外周感觉神经毒性,而血液学毒性、消化道副反应及肝肾毒性、脱发等轻微。结论 艾恒为主联合化疗治疗晚期实体肿瘤疗效良好,不良反应可以耐受,值得临床推广使用。     

IgA肾病的中医治疗经验

IgA肾病是肾小球系膜区以IgA为主的免疫球蛋白沉积的一种原发性肾小球肾炎，临床以发作性肉眼血尿与持续性镜下血尿为主要表现。其病因多为热在下焦，但热有实热与虚热之分，实热者为热盛伤络，迫血妄行；虚热者为阴虚内热，虚火扰络，络伤血溢。其次为脾气亏虚，气不摄血以及久病入络，气滞血瘀，络脉受损。治疗方法主要有清热凉血、养阴清热、益气健脾、活血化瘀等，但宜辨证与辨病相结合，才能提高疗效。     

小剂量碳酸锂与丙基硫氧嘧啶联合治疗甲状腺功能亢进症的近期疗效观察

目的碳酸锂、丙基硫氧嘧啶单独或小剂量联合治疗甲状腺功能亢进症的疗效比较。方法全部甲状腺功能亢进症病例共56例,随机分为3组:碳酸锂组17例,丙基硫氧嘧啶组19例,联合组(碳酸锂+丙基硫氧嘧啶)20例,治疗前及治疗2、4周测定血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺刺激素(TSH)及跟腱反射时间,比较3组疗效。结果3组治疗前甲状腺功能无明显差异,治疗后甲状腺功能均有明显下降,治疗2、4周时碳酸锂组、丙基硫氧嘧啶组FT3、FT4下降程度相似,联合组较另2组下降明显。结论碳酸锂能改善甲状腺功能,近期疗效与丙基硫氧嘧啶相似,联合治疗时其改善甲状腺功能效果将加强。     

头孢硫脒与6种抗菌药物联用对金葡球菌的体外抗菌活性

目的:评价头孢硫脒分别与万古霉素、奈替米星、阿米卡星、环丙沙星、左氧氟沙星和加替沙星6种抗菌药物联合用药,对于临床分离的金葡球菌(SA)的体外联合抗菌效应.方法:经VITEK鉴定临床分离致病菌,采用棋盘法设计,微量肉汤稀释法测定6组抗菌药物对SA及耐甲氧西林金葡球菌(MRSA)的最低抑菌浓度,并计算部分抑菌指数(FIC指数). 结果:头孢硫脒与万古霉素、奈替米星、阿米卡星、环丙沙星、左氧氟沙星、加替沙星联合应用后,MIC50,MIC90明显降低,FIC指数<0.5占60%～90%,0.5～1占10%～30%,1～2占0～13.3%,>2为0.结论:头孢硫脒与6种抗菌药物联合应用后,对SA基本表现为协同和相加作用,说明联合用药的疗效要高于两药单独使用.     

异环磷酰胺为主联合化疗方案治疗晚期非小细胞肺癌28例疗效观察

本文报告以异环磷酰胺为主联合化疗方案治疗晚期非小细胞肺癌28例，总有效率为35．7％。中位生存时间5月。主要毒副反应为骨髓抑制和脱发，发生率分别为100％和92．7％。其他毒副反应为肝功能损害和消化道反应，发生率分别为28．6％和28．6％。     

Evaluation of amlodipine, lisinopril, and a combination in the treatment of essential hypertension

Angiotensin converting enzyme (ACE) inhibitors and dihydropyridine calcium antagonists are well established and widely used as monotherapy in patients with mild to moderate essential hypertension. Earlier studies combining short acting drugs from these classes require multiple dosing and were associated with poor compliance. Availability of longer acting compounds allows once daily administration to avoid the inconvenience of a multiple daily dose. It was decided to perform a randomised double blind, crossover study with the long acting calcium channel blocker amlodipine and the long acting ACE inhibitor lisinopril, given either alone or in combination in essential hypertension. Twenty four patients with diastolic blood pressure (DBP) between 95 and 104 mm Hg received amlodipine 2.5 mg and 5 mg, lisinopril 5 mg and 10 mg, and their combination as per a prior randomisation schedule. Supine and standing blood pressure and heart rate were recorded at weekly intervals. Higher doses of both the drugs individually or in combination were used if the target supine DBP below 90 mm Hg was not achieved. There was a significant additional blood pressure lowering effect with the combination when compared either with amlodipine or lisinopril alone. Five mg amlodipine and 10 mg lisinopril monotherapy achieved the target blood pressure in 71% and 72% patients respectively. The combination of 2.5 mg amlodipine with 5 mg lisinopril produced a much more significant lowering of blood pressure in a higher percentage of patients than that with an individual low dose.     

黄连与黄芩、甘草配伍前后对金黄色葡萄球菌生长抑制作用的观察

以ＭＩＣ相对值为指标，观察黄连、黄芩、甘草煎液单味或不同比例配伍后对金黄色葡萄球菌生长的抑制作用。结果显示：黄连与黄芩配伍，黄芩的抑菌作用有所降低，但黄连则未见降低；黄芩多于黄连时，黄连的抑菌作用似有增强。黄连与甘草配伍，无论比例如何，配伍后的抑菌作用均呈降低趋势。当三药同时配伍时，黄连、甘草的抑菌作用不变，或反增强，只有黄芩的抑菌作用有减弱趋势。黄连与黄芩、甘草两两配伍，单独使用时，其抑菌作用似不如组成三药配伍。其机制值得进一步研究。