全文获取类型
收费全文 | 157356篇 |
免费 | 14191篇 |
国内免费 | 4303篇 |
专业分类
耳鼻咽喉 | 1473篇 |
儿科学 | 7717篇 |
妇产科学 | 4218篇 |
基础医学 | 19320篇 |
口腔科学 | 3274篇 |
临床医学 | 16995篇 |
内科学 | 24477篇 |
皮肤病学 | 2953篇 |
神经病学 | 13556篇 |
特种医学 | 3575篇 |
外国民族医学 | 6篇 |
外科学 | 13716篇 |
综合类 | 22726篇 |
现状与发展 | 21篇 |
一般理论 | 3篇 |
预防医学 | 10631篇 |
眼科学 | 2613篇 |
药学 | 9082篇 |
77篇 | |
中国医学 | 15682篇 |
肿瘤学 | 3735篇 |
出版年
2024年 | 287篇 |
2023年 | 2579篇 |
2022年 | 4098篇 |
2021年 | 7311篇 |
2020年 | 6917篇 |
2019年 | 6075篇 |
2018年 | 5986篇 |
2017年 | 6224篇 |
2016年 | 6300篇 |
2015年 | 5996篇 |
2014年 | 11152篇 |
2013年 | 11556篇 |
2012年 | 9163篇 |
2011年 | 10522篇 |
2010年 | 8346篇 |
2009年 | 7815篇 |
2008年 | 7579篇 |
2007年 | 7702篇 |
2006年 | 6902篇 |
2005年 | 5838篇 |
2004年 | 4933篇 |
2003年 | 4430篇 |
2002年 | 3115篇 |
2001年 | 2775篇 |
2000年 | 2394篇 |
1999年 | 2148篇 |
1998年 | 1744篇 |
1997年 | 1689篇 |
1996年 | 1620篇 |
1995年 | 1499篇 |
1994年 | 1334篇 |
1993年 | 1170篇 |
1992年 | 1039篇 |
1991年 | 828篇 |
1990年 | 742篇 |
1989年 | 649篇 |
1988年 | 639篇 |
1987年 | 551篇 |
1986年 | 497篇 |
1985年 | 682篇 |
1984年 | 560篇 |
1983年 | 361篇 |
1982年 | 433篇 |
1981年 | 385篇 |
1980年 | 313篇 |
1979年 | 274篇 |
1978年 | 172篇 |
1977年 | 135篇 |
1976年 | 114篇 |
1975年 | 60篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Heart rate variability and apnea during sleep in Down's syndrome 总被引:1,自引:1,他引:0
RAFFAELE FERRI LILIA CURZI-DASCALOVA STEFANO DEL GRACCO MAURIZIO ELIA SEBASTIANO MUSUMECI & SALVATORE PETTINATO 《Journal of sleep research》1998,7(4):282-287
Autonomic system dysfunction has been reported to occur frequently in patients with Down's syndrome (DS) and is constituted mainly by an imbalance between the sympathetic and vagal systems. The analysis of heart rate variability (HRV) during sleep is a quantitative reliable method for studying such a mechanism, but it has not yet been extensively and adequately applied in DS. In this study, HRV during sleep was evaluated in seven DS patients and in six normal controls, by also controlling for the presence of sleep apnea or arousal. The main results were an increased sympathetic function (low-frequency component of HRV) and a decreased vagal activity (high-frequency component of HRV) in DS with respect to normal controls, during apnea-free periods. Moreover, the presence of apnea, in DS, induced a further significant increase in low-frequency and very low-frequency components of HRV during sleep Stage 2. This study provides additional evidence of a brainstem dysfunctioning in DS, responsible for the abnormal imbalance between the sympathetic and vagal systems and confirms the brainstem involvement already suggested in the literature in order to explain brainstem-auditory evoked potential abnormalities and central sleep apnea in these patients. 相似文献
992.
Wolfgang H Oertel Tobias W?chter Niall P Quinn Gudrun Ulm Dirk Brandst?dter 《Movement disorders》2003,18(4):430-432
According to the consensus statement on the diagnosis of multiple system atrophy (MSA), erectile dysfunction is required for male patients to fulfil the urinary incontinence criterion. However, there is no equivalent item for female patients. We questioned 19 female patients with MSA of the parkinsonian type (MSA-P), 28 female patients with Parkinson's disease (PD), and 27 healthy controls on their genital sensitivity. A total of 47% of the MSA patients but only 4% of the PD patients and 4% of the control group admitted to reduced genital sensitivity, a highly significant difference (P < 0.001). Moreover, the appearance of reduced genital sensitivity in female MSA patients showed a close temporal relation to the onset of the disease. If these preliminary results can be confirmed and further specified in a larger sample, a historical item of reduced genital sensitivity in female patients might become a diagnostic feature for MSA, comparable to erectile dysfunction in male patients. 相似文献
993.
Carol J. Ludowese Kate J. Thompson Gurbax S. Sekhon Richard M. Pauli 《Clinical genetics》1991,40(3):194-201
We describe ten individuals with an insertional duplication 15q12----q13. Phenotypic analysis of these individuals and 15 previously reported cases of proximal 15q duplications fails to show any consistent clinical manifestations. It appears that a duplication of this region is phenotypically silent. 相似文献
994.
鞍区肿瘤术后中枢性低钠血症的诊断和治疗 总被引:2,自引:1,他引:1
目的:探讨鞍区肿瘤术后中枢性低钠血症的诊断及处理方法。方法:对我科近四年鞍区肿瘤术后并发中枢性低钠血症的58例患者进行回顾性分析,术前、手术当日及术后每日定时检测血钠,观察尿量变化,测定中心静脉压,确定低钠血症的类型并给予相应的处理。结果:56例恢复正常,1例死于严重肺部感染,1例自动出院。结论:鞍区肿瘤易出现抗利尿激素分泌不当综合症和脑性耗盐综合症两种类型。前者需限水治疗,后者应予以充分补钠、补水,根据水、钠检测水平治疗。 相似文献
995.
河南省传染性非典型肺炎患者胸部X线表现 总被引:1,自引:1,他引:0
目的 :探讨传染性非典型肺炎的X线表现及变化规律。方法 :对河南省临床诊断的 1 5例患者发病后不同时间的系列胸片和CT进行回顾性分析。结果 :1 5例胸部X线病灶初始形态为斑片状 1 1例 (73.3% ) ,大片状 4例 (2 6 .7% ) ;双侧 9例 (6 0 .0 % ) ,单侧 6例 (4 0 .0 % ) ,均为中、下肺野 (1 0 0 % )。动态观察发现病变进展快 ,病变发展到高峰期时间为 4~ 1 4d , x±s(7.7± 3.2 )d ,双侧 1 3例 (86 .7% ) ,单侧 2例 (1 3.3% ) ,两肺叶及两肺叶以上病变者 1 4例 (93.3% )。病变开始吸收时间为 6~ 2 1d , x±s(1 1 .3± 4 .1 )d ;完全或基本吸收时间 8~ 2 6d , x±s(1 6 .4± 5 .0 )d。1 5例经治疗均痊愈出院。住院时间 1 8~ 4 2d , x±s(31 .9± 7.9)d。 结论 :传染性非典型肺炎的胸部X线特点为急性双侧或单侧多叶炎性浸润阴影 ,以中、下野常见 ,进展迅速 ,及时复查胸部X线对临床诊断及判断病情具有重要价值。 相似文献
996.
997.
Xinyou Jiang 《Pediatric nephrology (Berlin, Germany)》1994,8(3):343-344
A preparation of extracts from the root of the Chinese medicinal herbTripterygium wilfordii Hook was administered orally at a dose of 1 mg/kg body weight per day to 13 children with idiopathic nephrotic syndrome. Eight children, including 4 who were steroid resistant, went into remission which was maintained in 4 for up to 3 years after withdrawal of treatment. In 3 children the proteinuria lessened with the return of plasma protein concentration to normal, and in 1 child this improvement was maintained for 4 years after treatment ceased. No serious side-effects were noted, but a temporary anti-fertility activity has been noted in other studies of both men and women. 相似文献
998.
Toshimichi Hasegawa Yuko Tazuke Yasuhiro Iwasaki Osamu Monta Junichi Sumimura Hiroshi Koyama Toru Dezawa 《Surgery today》1997,27(12):1191-1194
We report herein the case of a premature infant with esophageal atresia (EA) and a tracheoesophageal fistula (TEF) associated
with cardiac anomalies who was successfully treated by an early ligation of the TEF following gastrostomy, and delayed repair
of the esophagus. A 1212-g male was born prematurely at 31 gestational weeks, at which time he was diagnosed as having EA
with TEF and patent ductus arteriosus (PDA), ventricular septal defect (VSD), and atrial septal defect (ASD). A gastrostomy
was initially performed but following extubation he gradually became tachypneic. A chest roentogenogram revealed atelectasis
and ground-glass appearance, and reintubation was required. Ligation of the TEF was performed 53h after his birth. Following
the improvement of his respiratory condition through ventilatory support and the intratracheal administration of pulmonary
surfactant, he underwent repair of the esophagus on the 6th day of life. Postoperatively, he suffered from heart failure,
but was treated with peritoneal dialysis and pharmacological closure of the PDA. Weaning the infant from the ventilator proved
difficult, but it was finally achieved when he had reached a weight of 2268g at 3 months of age by enteral feeding. Our experience
of this case demonstrates that early ligation of TEF should be performed for a premature infant with EA and TEF before respiratory
distress syndrome (RDS) has developed. If a gastrostomy is required to prevent gastric distention, it should be followed by
simultaneous or immediate ligation of the TEF. 相似文献
999.
Edwina J. Popek R. Weslie Tyson Gary J. Miller Sherrie A. Caldwell 《Fetal and pediatric pathology》1991,11(1):1-29
Prune belly syndrome (PBS) has been recognized since 1950 as the triad of absent abdominal wall musculature, undescended testes, and urinary tract anomalies. The etiology, however, remains uncertain. Theories of mesenchymal maldevelopment, obstruction, and genetic origin have been proposed. To evaluate the role of lower urinary tract obstruction as it relates to prostatic development and PBS, we studied the lower urinary tract of 15 cases of PBS, 8 cases of posterior urethral values (PUV), and 34 age-matched controls. It is generally accepted that prostatic growth and development are dependent on mesenchymal-epithelial interactions. We evaluated the mesenchymal and epithelial differentiation and relationships, and found distinctly different and consistent abnormalities between PBS and PUV as compared with one another and controls. The findings suggest that in PBS, prostatic growth and development are hindered because of destruction or absence of the appropriate primitive mesenchyme. Our studies could not definitely exclude very early obstruction as a cause of the findings because of lack of appropriate fetal material. 相似文献
1000.
Interleukin-5 has a specific role in various eosinophilic activities. It is the predominant cytokine produces by activated T-lymphocytes isolated from patients with idiopathic hypereosinophilic syndrome. We studied a young patient suffering from idiopathic hypereosinophilic syndrome who presented with Horner's syndrome, peripheral neuropathy and skin ulcers. The IL-5 gene expression by CD4+ T-lymphocytes and the peripheral eosinophil count were raised. The skin ulcers continued to deteriorate despite a swift reduction of the IL-5 gene expression and peripheral eosinophil count following systemic corticosteroid treatment. We suggest that peripheral eosinophilia may not be responsible for the damage in skin lesions and more aggressive treatment may be required. 相似文献