全文获取类型
收费全文 | 18507篇 |
免费 | 1822篇 |
国内免费 | 414篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 1754篇 |
妇产科学 | 279篇 |
基础医学 | 1954篇 |
口腔科学 | 158篇 |
临床医学 | 1181篇 |
内科学 | 2840篇 |
皮肤病学 | 174篇 |
神经病学 | 868篇 |
特种医学 | 178篇 |
外科学 | 985篇 |
综合类 | 3061篇 |
现状与发展 | 2篇 |
预防医学 | 1710篇 |
眼科学 | 267篇 |
药学 | 789篇 |
10篇 | |
中国医学 | 4278篇 |
肿瘤学 | 196篇 |
出版年
2024年 | 69篇 |
2023年 | 341篇 |
2022年 | 604篇 |
2021年 | 1083篇 |
2020年 | 980篇 |
2019年 | 696篇 |
2018年 | 642篇 |
2017年 | 837篇 |
2016年 | 812篇 |
2015年 | 690篇 |
2014年 | 1272篇 |
2013年 | 1169篇 |
2012年 | 1010篇 |
2011年 | 1083篇 |
2010年 | 792篇 |
2009年 | 723篇 |
2008年 | 648篇 |
2007年 | 686篇 |
2006年 | 652篇 |
2005年 | 533篇 |
2004年 | 494篇 |
2003年 | 439篇 |
2002年 | 354篇 |
2001年 | 341篇 |
2000年 | 309篇 |
1999年 | 283篇 |
1998年 | 271篇 |
1997年 | 225篇 |
1996年 | 186篇 |
1995年 | 218篇 |
1994年 | 180篇 |
1993年 | 179篇 |
1992年 | 162篇 |
1991年 | 174篇 |
1990年 | 151篇 |
1989年 | 145篇 |
1988年 | 143篇 |
1987年 | 119篇 |
1986年 | 118篇 |
1985年 | 152篇 |
1984年 | 116篇 |
1983年 | 74篇 |
1982年 | 109篇 |
1981年 | 92篇 |
1980年 | 69篇 |
1979年 | 79篇 |
1978年 | 45篇 |
1977年 | 43篇 |
1976年 | 49篇 |
1975年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
911.
Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt 《World Journal of Virology》2020,9(5):67-78
Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells. In this review, we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1. Considering the known biochemical properties including antibacterial and antiviral properties, time-honored applications, and the new promising findings regarding the use of thymosin, we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. 相似文献
912.
Stephanie Griggs Nancy S. Redeker Sybil L. Crawford Margaret Grey 《Research in nursing & health》2020,43(4):317-328
Type 1 Diabetes (T1D) affects 1.6 million Americans, and only 14% of emerging adults ages 18–25 years achieve targets for glycemic control (A1C < 7.0%). Sleep deficiency, including habitual short sleep duration (<6.5 hr total sleep time and high within-person variability in total sleep time), is associated with poorer glycemic control. Emerging adults with T1D have a more pronounced sleep extension on weekends compared with matched controls, consistent with sleep deficiency; however, associations among sleep variability and glycemic control have not been explored in this population. Sleep deficiency may affect the complex higher-order neurocognitive functioning needed for successful diabetes self-management (DSM). We report the protocol for an ongoing study designed to characterize sleep and the associations among sleep deficiency, neurocognitive function, DSM, diabetes quality of life, and glycemia among a sample of 40 emerging adults with T1D. We monitor sleep via wrist-worn actigraphy and glucose via continuous glucose monitoring concurrently over 14 days. We are collecting data on self-report and objective sleep, a 10-min psychomotor vigilance test on a PVT-192 device, a 3-min Trail Making Test on paper, and questionnaires, including twice-daily Pittsburgh sleep diaries using Research Electronic Data Capture (REDCap)TM. Results from this study will be used to support the development and testing of the efficacy of a tailored sleep self-management intervention that may improve total sleep time, sleep variability, neurocognitive function, DSM, glycemic control, and glucose variability among emerging adults with T1D. 相似文献
913.
Teng Jiang Jin-Tai Yu Xi-Chen Zhu Meng-Shan Tan Li-Ze Gu Ying-Dong Zhang Lan Tan 《Neurobiology of aging》2014
As a major characteristic of aging process, neuroinflammation is involved in the pathogenesis of several aging-related diseases including Alzheimer's disease (AD). Triggering receptor expressed on myeloid cells 2 (TREM2) is a newly identified risk gene for AD, which regulates inflammatory process in peripheral tissues via modulating the release of inflammatory cytokines. However, the role of TREM2 in aging-related neuroinflammation, cognitive deficiency, and AD-like neuropathology is unclear so far. Here, we detected the protein levels of TREM2 in brain of 3-, 7-, and 11-month-old senescence-accelerated mouse prone 8 (SAMP8) mice and observed that TREM2 levels were increased during aging process. We then knocked down TREM2 expression in brain of SAMP8 mice by nonviral RNA interference and found a significant increase in proinflammatory cytokines including tumor necrosis factor-α and interleukin (IL)-6, which was accompanied by a reduction in IL-10. Meanwhile, more obvious neuronal and synaptic losses and cognitive impairment were observed. These findings indicate that TREM2 may play a protective role against aging-related neuroinflammation and cognitive impairment. 相似文献
914.
Hemophagocytic lymphohistiocytosis (HLH) is characterized by uncontrolled immune activation and is traditionally associated with inherited gene defects or acquired causes. In addition to abnormalities in cytotoxic granules and lysosomes, various primary immune deficiency disorders (PID) have been identified among patients suffering from HLH. Our purpose was twofold: to better characterize and detail the association between PID and HLH. 相似文献
915.
A case of Robin sequence,microgastria, radiohumeral synostosis,femoral deficiency,and other unusual findings: A newly recognized syndrome? 下载免费PDF全文
916.
Mutations in HADHB,which encodes the β‐subunit of mitochondrial trifunctional protein,cause infantile onset hypoparathyroidism and peripheral polyneuropathy 下载免费PDF全文
917.
918.
919.
920.