全文获取类型
收费全文 | 11414篇 |
免费 | 1167篇 |
国内免费 | 277篇 |
专业分类
耳鼻咽喉 | 1084篇 |
儿科学 | 482篇 |
妇产科学 | 14篇 |
基础医学 | 2686篇 |
口腔科学 | 14篇 |
临床医学 | 440篇 |
内科学 | 813篇 |
皮肤病学 | 3597篇 |
神经病学 | 364篇 |
特种医学 | 69篇 |
外国民族医学 | 1篇 |
外科学 | 59篇 |
综合类 | 1197篇 |
预防医学 | 292篇 |
眼科学 | 140篇 |
药学 | 874篇 |
9篇 | |
中国医学 | 677篇 |
肿瘤学 | 46篇 |
出版年
2024年 | 26篇 |
2023年 | 117篇 |
2022年 | 205篇 |
2021年 | 357篇 |
2020年 | 335篇 |
2019年 | 342篇 |
2018年 | 355篇 |
2017年 | 403篇 |
2016年 | 437篇 |
2015年 | 372篇 |
2014年 | 647篇 |
2013年 | 770篇 |
2012年 | 599篇 |
2011年 | 626篇 |
2010年 | 471篇 |
2009年 | 477篇 |
2008年 | 469篇 |
2007年 | 477篇 |
2006年 | 412篇 |
2005年 | 403篇 |
2004年 | 358篇 |
2003年 | 351篇 |
2002年 | 288篇 |
2001年 | 306篇 |
2000年 | 207篇 |
1999年 | 294篇 |
1998年 | 306篇 |
1997年 | 267篇 |
1996年 | 263篇 |
1995年 | 254篇 |
1994年 | 221篇 |
1993年 | 203篇 |
1992年 | 196篇 |
1991年 | 178篇 |
1990年 | 165篇 |
1989年 | 179篇 |
1988年 | 144篇 |
1987年 | 58篇 |
1986年 | 56篇 |
1985年 | 46篇 |
1984年 | 56篇 |
1983年 | 38篇 |
1982年 | 27篇 |
1981年 | 18篇 |
1980年 | 15篇 |
1979年 | 18篇 |
1978年 | 10篇 |
1977年 | 6篇 |
1976年 | 15篇 |
1975年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 281 毫秒
11.
Y. Graif A. Goldberg R. Tamir D. Vigiser S. Melamed 《Clinical and experimental allergy》2006,36(12):1532-1537
BACKGROUND: In allergic conditions, the degree of skin test reactivity does not always correlate with the severity of clinical symptoms. Additional factors may contribute to the reported symptom severity. OBJECTIVES: To investigate the association between the magnitude of the skin prick test (SPT) response and the reported symptom severity in patients with allergic rhinitis and the possible modifying role of psychological factors. METHODS: One hundred four patients with allergic rhinitis and 23 with non-allergic rhinitis, classified according to their SPT response to 19 aeroallergens, were asked to rate the severity of five symptoms and to indicate whether their symptoms intensified on exposure to five common aeroallergens. They also completed a psychological questionnaire. Results Reported symptom severity of allergic rhinitis did not correlate with weal size for any of the aeroallergens tested or with the number of positive responses on SPT. It was not related to patient age, sex, or education. The reported symptoms severity correlated positively (0.29, P < 0.01) with reported symptom intensification on exposure to allergens. Moreover, both outcomes were positively associated with the psychological factors of hypochondriasis (0.20, P < 0.05 and 0.18, P < 0.05, respectively), and somatic awareness (0.24, P < 0.05 and 0.33, P < 0.01, respectively), but not with neuroticism. CONCLUSIONS: The severity of symptoms experienced by patients with allergic rhinitis is apparently not related to the magnitude of SPT response, but rather to psychological factors of hypochondriasis and somatic awareness. Physicians should be aware of the contribution of psychological factors to patient perceptions of the intensity of symptoms and of the intensification of symptoms on their exposure to allergens. 相似文献
12.
Local mucosal immunoglobulin E production: does allergy exist in non‐allergic rhinitis? 总被引:2,自引:0,他引:2
In this review, we critically evaluate the evidence for local IgE production in allergic rhinitis mucosa and the concept of local allergy in non-atopic idiopathic rhinitis. Significantly, fewer studies have focused on the disease pathways associated with non-allergic rhinitis compared with their allergic counterparts. Recently, there's been a revival of the hypothesis concerning the existence of local tissue-specific allergic disease confined to the nasal mucosa of some systemically non-atopic rhinitis subjects. Providing the evidence for local mucosal IgE production in allergic rhinitis is a pre-requisite to reviewing its existence in non-allergic rhinitis. In addition, practical and theoretical approaches useful in the detection of allergy in non-allergic rhinitis will be discussed. Furthermore, successful therapeutic regimens used in the treatment of non-allergic rhinitis will be examined as these could provide an insight into the underlying pathophysiology of this common but poorly understood disease. 相似文献
13.
14.
15.
16.
Dissociation of GFAP intermediate filaments in EAE: observations in the lumbar spinal cord 总被引:1,自引:0,他引:1
Acute experimental allergic encephalomyelitis (EAE) in the Lewis rat is a cell-mediated autoimmune disease of central nervous system myelin. The lesion has been characterized by breakdown of the blood-brain barrier, edema, and periventricular infiltration of macrophages and lymphocytes. At the early stage of the disease, the astrocytes show a marked increase in immunostaining for glial fibrillary acidic protein (GFAP). A corresponding increase in GFAP content, however, cannot be demonstrated. Electron microscopic examination of the early lesion shows a typical reactive astrocytic response expressed by an enlarged watery cytoplasm, particularly at the level of the processes surrounding neurons and blood vessels and in the neuropil itself. The astroglial processes contain numerous glycogen particles (aggregates and single particles). Glial filaments are also conspicuous and are arranged in small bundles or loose thin filaments adjacent to the bundles. The glial filaments that normally appear as tight bundles have expanded and appear less dense. We suggest that the increase in GFAP immunostaining of the astrocytes in the early lesion is due in part to edema, which causes dissociation of the filaments and thereby exposes more antigenic sites to the antibodies. 相似文献
17.
Occupational airborne allergic contact dermatitis from tylosin 总被引:2,自引:1,他引:1
18.
19.
Giorgio Ciprandi Mara De Amici Simone Negrini Gianluigi Marseglia Maria Angela Tosca 《International immunopharmacology》2009,9(10):1247-1249
Two new T cell subsets may be involved in allergic rhinitis (AR) pathogenesis: Th17 and T regulatory cells, mainly producing IL-17 and TGF-β respectively. Successful Sublingual Immunotherapy (SLIT) induces relevant immunological changes, thus the aim of this study was to evaluate serum IL-17 and TGF-β levels in AR patients treated with SLIT for 2 years. Patients' blood samples were collected before initiating SLIT (baseline), three months after the end of the first pre-seasonal SLIT course, and at the end of the second pre-seasonal course. IL-17 was detectable only in the most severe allergic patients. SLIT significantly induced an increase in serum TGF-β levels. There was moreover a significant relationship between TGF-β and symptom severity and drug use at the end of the study. Therefore, this study provides clinically relevant evidence that two pre-seasonal SLIT courses may significantly affect serum TGF-β levels. 相似文献
20.
Contact sensitivity to aluminium acetate eardrops 总被引:1,自引:0,他引:1