中药足浴配合中药保留灌肠治疗慢性溃疡性结肠炎的疗效观察

目的观察中药足浴疗法加中药保留灌肠对慢性溃疡性结肠炎(UC)患者治疗效果的影响。方法将120例慢性溃疡性结肠炎患者随机分为治疗组和对照组各60例,对照组采用中药保留灌肠治疗,治疗组加用中药足治疗,连续治疗21d,观察治疗前后症状、体征、大便常规检查及肠镜检查变化。结果治疗组与对照组总有效率分别为86.67%和65.00%,经统计学处理,P<0.01,表明两组比较差异有显著性。结论中药足浴疗法加中药保留灌肠治疗慢性溃疡性结肠炎疗效显著。     

A Case of Treating Cathinone Dependence and Comorbid Depression Using Bupropion

Abstract

Cathinone is a potent CNS stimulant found in khat leaves. Cathinone and synthetic cathinone-derivatives have become popular recreational drugs in recent years, commonly marketed as “legal highs.” In addition to acute physical and psychiatric adverse effects, dependence on these substances is a concern. The following case reports describes a young man with cathinone dependence and depression that was treated using bupropion. Bupropion is a cathinone-derivative with a dual dopamine-norepinephrine reuptake inhibiting mechanism, which is approved for the treatment of depression and smoking cessation. Clinical awareness to the addictive potential of cathinone and cathinone-derivatives is important. Research regarding the potential effectiveness of bupropion in these cases is needed.     

坐浴外洗联合环状混合痔术治疗术后并发症随机平行对照研究

[目的]观察坐浴外洗联合环状混合痔术治疗术后并发症疗效。[方法]使用随机平行对照方法,将70例住院患者按抛硬币法随机分为两组。对照组35例环状混合痔术,术前患者清淡、半流质饮食。术前1d清洁灌肠。手术取右侧卧位,碘伏消毒,局部麻醉。肛镜下对直肠上动脉区及痔体注入30mL消痔灵液。外痔较大混合痔行外剥内扎术,外痔较小混合痔则行弧形切除缝合术。术后,将1枚消炎痛栓纳入肛门,并用凡士林纱布填压创面,最后压迫包扎固定。每日便后,温水坐浴外洗,结束后油纱条换药。治疗组35例坐浴外洗(黄柏30g,黄连15g,苦参、地榆、延胡索各30g,白芷15g),水煎500mL,排便后坐浴,时间30min。结束后生肌玉红膏纱条换药;环状混合痔术同对照组。连续治疗14d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈33例,好转2例,无效0例,痊愈率94.29%。对照组痊愈27例,好转8例,无效0例,痊愈率77.14%。治疗组疗效优于对照组(P0.05)。[结论]坐浴外洗联合环状混合痔术治疗术后并发症效果显著,值得推广。     

中药药浴联合穴位按摩治疗小儿外感发热86例

目的观察中药药浴联合穴位按摩治疗小儿外感发热的临床疗效。方法将174例外感发热患儿随机分为治疗组(86例)与对照组(88例)。两组均予炎琥宁注射液静脉滴注,治疗组加用中药药浴及穴位按摩,对照组加用普通温水浴。两组疗程均为3天,观察临床疗效及体温变化情况。结果①治疗组、对照组总有效率分别为96.51%、85.22%;组间临床疗效比较,差异有统计学意义(P0.05)。②组内比较,两组治疗前与治疗当天、治疗前与治疗72 h后、治疗当天与治疗72 h后体温值差异均有统计学意义(P0.05)。组间比较,治疗前体温值差异无统计学意义(P0.05),治疗当天体温值差异有统计学意义(P0.05),治疗72 h后体温值差异有统计学意义(P0.05)。结论中药药浴联合穴位按摩治疗小儿外感发热临床疗效满意,且解热起效快、体温不反弹。     

中药超声波足浴结合穴位按摩治疗变应性鼻炎的临床研究

目的:观察中药超声波足浴结合穴位按摩对变应性鼻炎患者的治疗作用并探讨其作用机制。方法:将100例患者随机分为对照组(50例)、治疗组(50例),对照组口服氯雷他啶,治疗组采用中药超声波足浴并结合穴位按摩治疗,两组均治疗30天后进行疗效评定并检测治疗前后血清白介素4(IL-4)、IgE水平。结果:治疗组总有效率为90.00%,与对照组(64.00%)比较差异有统计学意义(P0.05)。治疗前两组患者血清IL-4、IgE水平较正常组显著升高,治疗后两组患者血清IL-4、IgE水平明显降低,治疗组下降更明显,差异有统计学意义(P0.05)。结论:中药超声波足浴结合穴位按摩能有效的治疗变应性鼻炎,降低变应性鼻炎患者血清中IL-4、IgE水平、改善患者的体质是其作用机制之一。     

壮医药线点灸对类风湿关节炎血清肿瘤坏死因子α及白细胞介素1β的影响

目的：观察壮医药线点灸治疗对类风湿关节炎（RA）血清肿瘤坏死因子仪及白细胞介素1β的影响,探讨其治疗机制。方法：选取活动性类风湿关节炎90例,随机分为药线治疗组30例,空白线灸组30例,西药对照组30例,药线治疗组和空白线灸组分别采用壮医药线、空白苎麻线点灸,同时配合西药治疗,采用ELISA法检测治疗前后3组患者的血清TNF-α和IL-1β。结果：药线治疗组治疗后与治疗前比较TNF-α、IL-1β有显著性差异（P〈0．01）,药线治疗组治疗后TNF-α、IL—1β较空白线灸组和西药对照组治疗后也有明显降低（P〈0．05）。结论：壮医药线点灸治疗可降低RA患者的血清TNF-α、IL-1β水平,这是其可能的治疗机制。     

藻酸钙敷料联合消炎坐浴洗剂治疗糖尿病肛周脓肿的疗效观察和护理

目的探讨藻酸钙敷料联合消炎坐浴洗剂治疗糖尿病肛周脓肿的临床疗效。方法将34例糖尿病肛周脓肿患者随机均分为观察组(藻酸钙敷料联合消炎坐浴洗剂)与对照组(传统方法),比较2组治疗有效率及平均治愈时间。结果观察组治疗有效率明显高于对照组(P<0.05),平均愈合时间明显短于对照组(P<0.01)。结论使用藻酸钙敷料联合消炎坐浴洗剂治疗糖尿病肛周脓肿明显优于传统治疗方法,具有治愈率高、伤口愈合快等优点。     

The development and characterization of an ELISA specifically detecting the active form of cathepsin K

Objective

Cathepsin K plays essential roles in bone resorption and is intensely investigated as a therapeutic target for the treatment of osteoporosis. Hence an assessment of the active form of cathepsin K may provide important biological information in metabolic bone diseases, such as osteoporosis or ankylosing spondylitis.

Methods

Presently there are no robust assays for the assessment of active cathepsin K in serum, and therefore an ELISA specifically detecting the N-terminal of the active form of cathepsin K was developed.

Results

The assay was technically robust, with a lowest limit of detection (LOD) of 0.085 ng/mL. The average intra- and inter-assay CV% were 6.60% and 8.56% respectively. The dilution recovery and spike recovery tests in human serum were within 100 ± 20% within the range of the assay.A comparison of latent and active cathepsin K confirmed specificity towards the active form. Quantification of the levels of active cathepsin K in supernatants of purified human osteoclasts compared to corresponding macrophages showed a 30-fold induction (p < 0.001).In contrast, in serum samples from osteoporotic women on estrogen or bisphosphonate therapy and from ankylosing spondylitis patients no clinically relevant differences were observed.

Conclusion

In summary, we have developed a robust and sensitive assay specifically detecting the active form of cathepsin K; however, while it monitors osteoclasts with high specificity in vitro, it appears that circulating levels of active cathepsin K do not reflect bone changes under these circumstances.     

Effectiveness of the Sitz bath in managing adult patients with anorectal disorders

Objective: The objective of this review was to critically analyze and systematically review the best evidence related to the effectiveness of the Sitz bath in managing adult patients with anorectal disorders. Methods: The text terms were established and searched systematically from the relevant databases from 1990 to November 2009 in the English language. The eligible studies that were congruent with the review's inclusion criteria were selected. The selected studies were critically appraised for their methodological validity by two independent reviews and the data were extracted from the studies by using the Joanna Briggs Institute Systems Meta Analysis of Statistical Assessment and Review Instrument. The results were presented in narrative form because statistical pooling was not possible due to clinical heterogeneity. Results: A total of four randomized controlled trials was included in the review. The use of the Sitz bath had no significant impact on reducing the overall intensity of pain and postoperative pain. Conflicting findings for postdefecation pain were reported. The Sitz bath had no impact on accelerating fissure or wound healing. However, the patients were satisfied with using the Sitz bath and no severe complication was reported. Conclusion: There was no strong evidence to support the use of the Sitz bath for pain relief and to accelerate fissure or wound healing among adult patients with anorectal disorders. However, the Sitz bath may be prescribed for patients' satisfaction.     

脑瘫患儿332例临床资料与疗效分析

目的：探讨脑瘫患儿的致病因素及治疗效果,降低脑瘫患儿发生率和残疾发病程度。方法：将332例脑瘫患儿分为观察组（246例）和对照组（86例）,两组患儿均给予运动功能训练法、针灸、按摩及西药治疗,治疗组在此基础上加用中药药浴,治疗3个月,采用修订的Asworth痉挛量表对治疗前后的痉挛程度进行评价。结果：在肌张力的缓解上,观察组总有效率为86.2%,对照组总有效率为48.8%,两组总有效率比较差异有高度统计学意义（χ2=49.44,P〈0.01）。结论：做好围生期保健是降低脑瘫发病率的关键,中药药浴治疗小儿脑瘫可以明显降低患儿肌张力,增加关节活动度,矫正异常姿势,改善患儿的运动功能。