山东产四种菟丝子免疫增强作用的比较研究

目的 比较山东产四种菟丝子对小鼠免疫功能、抗疲劳、耐缺氧等方面的作用。方法 选用昆明种小鼠，用山东产四种菟丝子的水、醇提取物灌胃，观察小鼠腹腔巨噬细胞吞噬功能、免疫器官重量的变化、游泳实验和耐缺氧等指标。结果 山东产四种菟丝子均可增加小鼠吞噬百分率，使幼龄小鼠的胸腺和脾脏增重，并可显著延长小鼠的游泳及缺氧存活时间。其中以菟丝子和南方菟丝子的作用较好，水提取物的作用优于醇提取物。结论 山东产四种菟丝子具有增强机体免疫功能、抗疲劳、耐缺氧作用。菟丝子中的多糖是其提高机体免疫力，增强体质的有效物质之一。     

Lymphocyte T helper-specific reactivity in sustained responders to interferon and ribavirin with negativation (seroreversion) of anti-hepatitis C virus.

BACKGROUND: Seroreversion, negativation of anti-hepatitis C virus previously positive, is sometimes found in some chronic hepatitis C-sustained responders (SRs) to antiviral therapy. AIMS: To determine the probability of seroreversion in SR treatment with Interferon and Ribavirin, and lymphocyte T helper (CD4+) reactivity to HCV antigens. METHODS: Thirty SR were followed on average for 54.8 months. Anti-HCV was tested by third generation test. Peripheral blood mononuclear cells (PBMCs) were isolated from venous blood and cultured to evaluate CD4+ proliferation in response to 2 microg/ml of eight HCV recombinant antigens from core, NS3, NS4, NS5 regions. RESULTS: Seroreversion was verified in 23% of patients (7/30), appearing at 47.5+/-24.0 months. The probability of anti-HCV loss in this group was 25% at 56 months after ending therapy. In 57% (4/7), anti-HCV returned to positive. These 7 SR patients with seroreversion also showed weaker CD4+ reactivity in 5% of tests (3/56) than the remaining 23 anti-HCV-positive SRs who showed stronger reactivity in 18% of tests (33/184), P=0.036. CONCLUSIONS: One-quarter of the SR showed seroreversion of anti-HCV and weaker CD4+ specific HCV proliferation than those who remained anti-HCV positive. The data suggest that complete viral eradication is a possible and achievable clinical objective.     

佳沽士含三氯生牙膏和佳沽士防蛀修复牙膏抑菌作用的比较研究

目的：比较佳洁士含三氯生牙膏和佳洁士防蛀修复牙膏的抑菌效果及作用时间。方法：选用变形链球菌、牙龈卟啉单胞菌等为实验菌株，用微孔板微量液体稀释法对两种牙膏进行细菌敏感实验，比较二者对不同菌株的最低抑菌浓度（MIC）；并选择22名受试者，在晚间和清晨分别使用两种牙膏按指定方法刷牙后，观察两种牙膏抑菌作用的持续时间。结果：①含三氯生牙膏对5种菌的抑菌浓度均低于防蛀修复牙膏。@22名受试者使用含三氯生牙膏刷牙后，清晨抑菌作用保持率为81．8％，日间检出率下降，为40．9％；防蛀修复组抑菌作用保持率为0。统计学差异具有显著性意义。结论：佳洁士含三氯生牙膏抑菌作用较强，使用后能持续发挥抑菌作用，其夜间抑菌作用优于日间。     

Ⅴ-Ti催化剂低氧催化氧化邻二甲苯制苯酐——Ⅱ.TiO_2晶体结构及助剂作用的影响

研究了V-Ti体系中TiO_2晶体结构与催化活性的联系,本系统中,当焙烧温度超过650℃,由于TiO_2由锐钛矿型转变为金红石型,使催化活性降低。助剂作用的ESCA、XRD、LRS研究表明,与通常V-Ti系催化剂不同,本催化剂由于助剂的作用,使V=O键减弱而利于活化;且随K助剂含量增加,V_2O_(4.33)晶胞的001面取向优化加强,更宜于催化活性的充分显示。     

松花粉抗衰老作用的实验研究

目的　观察松花粉的抗衰老作用。方法　用含松花粉的饲料喂养衰老小鼠 ,测定小鼠血清中超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT)、谷胱甘肽过氧化物酶 (GSH Per)的活性 ,测定脑组织中丙二醛 (MDA)含量及脑组织和肝脏中的脂褐质 (Lf)含量 ,同时测定胸腺和脾脏的重量及网状内皮系统的吞噬功能。结果　松花粉能明显增加衰老小鼠血清中SOD、CAT、GSH Per活性 ,降低脑组织中MDA含量及脑组织和肝脏中的Lf含量 ,并增加胸腺和脾脏质量 ,提高网状内皮系统吞噬功能。结论　松花粉具有抗衰老作用     

Electrochemical investigation of formic acid electro-oxidation and its crossover through a Nafion® membrane

This work studies formic acid as an anode fuel for polymer electrolyte fuel cells and investigates the electro-oxidation of formic acid on Pt/C. Fuel crossovers through the Nafion^® 115 membrane at different temperatures and concentrations are reported. A linear dependence of the crossover current on the temperature and concentration is obtained. It is found that the crossover can be reduced by five times and a higher performance can be rendered by formic acid when compared to methanol under the same conditions. Electrochemical impedance measurements are conducted to interpret the reaction mechanism of formic acid oxidation. The effect of the electrode potential on the impedance pattern is revealed and an impedance model incorporating the reaction kinetics information is developed to simulate the experimental impedance response.     

FIA—fluorimetric determination of thiamine

A flow injection-fluorimetric determination of thiamine is reported. The procedure is based on the oxidation of the analyte with potassium hexacyanoferrate(III) immobilized on an anionic exchange resin; the fluorescence is monitored in aqueous basic solution. Concentrations of the vitamin of 0.1–4 ppm have been determined; the relative standard deviation was 1.8%. The injection rate was 28 samples/h. The influence of other substances and the determination of the drug in a pharmaceutical formulation are also reported.     

新型麻醉药异丙酚的氧化动力学

采用高效液相色谱法测定了异丙酚在不同温度下及其甲醇 水（Ｖ∶Ｖ＝７０∶３０）混合溶液在不同ｐＨ值下的反应速率常数，并求出了异丙酚氧化反应的活化能，结果表明ｐＨ值与温度对异丙酚的氧化动力学均有影响     

白芍总甙促干扰素诱生及抗病毒作用的研究

研究白芍总甙的促干扰素诱生及抗病毒作用,结果表明;白芍总甙10 mg·L~(-1)在试管内无直接诱生干扰素(JFN)作用.可促进鸡新城疫互I系弱毒冻干疫苗诱生αIFN,其最适浓度为10 mg·L~(-1)可促进ConA诱生γIFN.当ConA为亚适剂量时,最适浓度为l～10 mg·L~(-1)当ConA为最适剂量时,其最适浓度为0.1 ～1mg·L~(-1),皆可提高IFN效价l～2倍。具有直接抗病毒作用,白芍总甙250 mg·L~(-1)能使水泡性口炎病毒效价下降2.22个对数值。     

提高H2O2/甲酸体系选择性氧化抽提脱硫效率的研究

为了降低焦化蜡油(CGO)-甲酸／H2O2选择性氧化体系中H2O2的无效分解速度，屏蔽重金属离子对H2O2分解的催化效应，考察了造纸行业中常用的硅酸钠、硅酸镁和乙二胺四乙酸(EDTA)等稳定剂和螯合剂的加入对有机溶剂抽提后CGO中含硫量的影响。实验结果表明，EDTA可以很好地和重金属离子螯合，氧化后CGO抽余油中硫含量大幅降低。