丁香酚痤疮凝胶剂的处方设计及初步质量评价

目的丁香酚凝胶剂的制备工艺与初步质量评价。方法用卡波姆-940作基质,三乙醇胺为中和剂,加入丁香酚制成凝胶剂;采用紫外分光光度法以及气相色谱法直接测定凝胶剂中丁香酚的含量。结果制备的凝胶剂,细腻、光洁透明、稳定性好、释放药物快,且含量测定简单易行。结论该凝胶剂配方合理,符合《中国药典》2000版的规定,适宜于痤疮的治疗。     

青少年寻常痤疮发病规律的流行病学研究

目的:探讨青少年寻常痤疮发病规律及其与机体病理变化的关系.方法:应用流行病学调查方法研究840名青少年学生的寻常痤疮发病率、发病年龄、性别特点及面部皮损特征.结果:1.青春期寻常痤疮患病率为86.9%,男性患病率高于女性(P＜0.01);2.发病年龄在12～17岁之间,男性发病年龄大于女性(P＜0.05);3.青春期患者痤疮是以正常肤色的白头粉刺为主,数量在30个以内,皮损单一;4.面部皮损分区以左右分布为主(P＜0.01).结论:青春期是寻常痤疮的高发期,其患病率、皮损程度、分布与年龄、性别具有密切关系.     

凉血四物汤在皮肤病中运用

李治牢主任医师运用凉血四物汤加减治疗血热瘀滞证所引起的不同的皮肤病症方面,经验丰富,见解独到,临床疗效良好,体现了中医的"异病同治"的特点.     

自制甲-丁溶液治疗痤疮疗效观察

目的探讨自制甲—丁溶液治疗痤疮的疗效。方法治疗组用0.5%甲硝唑注射液100ml加丁胺卡那注射液0.4g配成甲—丁溶液后湿敷于患处,每周1次;对照组外用2%氯霉素酒精酊,1天1次;连用4周,对治疗效果对比分析。结果治疗组175例患者中,痊愈45例,占25.7%,总有效率为98.28%,对照组痊愈率和总有效率分别为13.2%和72.5%,两组相比,P值均小于0.05,均有显著性差异。结论我们自配的甲—丁溶液和传统的2%氯霉素酒精酊相比,治疗痤疮具有疗效好、操作简单、副作用少等优点,临床应用价值较大。     

Our approach to pediatric dermatologic laser surgery

BACKGROUND AND OBJECTIVES: Many pediatric dermatological conditions may be successfully treated with laser surgery. STUDY DESIGN/MATERIALS AND METHODS: The clinical approach to various pediatric dermatological conditions utilizing laser treatment options is discussed. RESULTS: Clinical uses of various modalities such as pulsed dye laser, KTP laser, Nd-YAG laser, Q-switched ruby laser, erbium-YAG laser, diode laser, non-coherent blue light sources, and fractional resurfacing are presented with successful parameters, developed over 22 years, utilized on a daily basis in a laser surgery clinic. CONCLUSION: Laser surgery can make a significant improvement in many pediatric skin lesions, thanks to the unique properties of pediatric skin and a vast array of laser technologies.     

Induction of toll-like receptors by Propionibacterium acnes

BACKGROUND: The bacterium Propionibacterium acnes is involved in the induction and maintenance of the inflammatory phase of acne. Recent studies have found that keratinocytes express toll-like receptors (TLRs) implicated in immediate immunity. No studies have, to date, been carried out on the action of P. acnes upon TLR activation in keratinocytes. OBJECTIVES: Focusing on the inflammatory phase of acne, to clarify the role of P. acnes in immediate immunity by inducing expression of TLR-2 and TLR-4 by keratinocytes. We also studied how the secretion and expression of matrix metalloproteinase (MMP)-9 is induced by P. acnes. METHODS: The work was carried out on two levels: in vivo with the study of the expression of TLR-2 and TLR-4 proteins in biopsies of acne lesions and in vitro on cultured keratinocyte monolayers to study the modulating effects of P. acnes on the expression of TLR-2 and TLR-4 and also on the expression and secretion of MMP-9. RESULTS: Our findings reveal that in vivo TLR-2 and TLR-4 expression is increased in the epidermis of acne lesions. In vitro, an increase in TLR-2 and TLR-4 expression by human keratinocytes occurred in the first hours of incubation with bacterial fractions as well as an increase of the expression and secretion by the keratinocytes of MMP-9, which plays a role in inflammation. CONCLUSIONS: This work demonstrates that P. acnes induces TLR expression and that this mechanism could play an essential role in acne-linked inflammation. These receptors could be involved notably in acute acne.     

Ocular surface disorders and tear function changes in nodulo-cystic acne

The aim of this study was to investigate the ocular surface disorders and tear function changes in patients with nodulo-cystic acne. Eighty-seven patients with nodulo-cystic acne vulgaris and 50 healthy subjects were included in the study. All subjects underwent full ocular examinations. Subjective ocular complaints were recorded. Corneal staining with fluorescein, tear film break-up time (BUT), and Schirmer test were applied. Abnormal tear film BUT and abnormal Schirmer scores were significantly more common in the acne group than in the control group. The tear film BUT was abnormal in 18 (20.7%) cases in the patient group and in 2 (4%) subjects in the control group (p=0.007). The mean Schirmer score was abnormal in 7 (8%) and decreased in 18 (20.7%) acne patients, and it was decreased in only 3 (6%) control subjects (p=0.005). Corneal punctuate epithelial erosions were detected in 3 (3.4%) acne patients, but not any of the control subjects. However, the difference between the groups was not statistically significant (p=0.184). Subjective ocular complaints were present in 28 cases (32.2%) in the patient group. Five (10%) subjects in the control group had such complaints (p=0.003). Tear function tests are also significantly altered in patients with nodulo-cystic acne. Our data suggest that severe acne patients should be referred to an ophthalmologist.     

Abnormal production of tumor necrosis factor (TNF) -- alpha and clinical efficacy of the TNF inhibitor etanercept in a patient with PAPA syndrome [corrected

We report a family with pyogenic sterile arthritis, pyoderna and acne syndrome (PAPA). The proband presented several episodes of sterile pyogenic arthritis and became unresponsive to glucocorticoids. After treatment with the tumor necrosis factor inhibitor etanercept, the disease underwent rapid and sustained clinical remission. Production of tumor necrosis factor-alpha by mononuclear cells of the proband and of the affected relatives was abnormally elevated.     

Treatment of rhinophyma with Er:YAG laser

BACKGROUND AND OBJECTIVE: Rhinophyma is a benign, disfiguring disorder of the nose which presents the end stage of acne rosacea, and can also occasionally result in nasal airway obstruction. We describe the first series of patients treated with Erbium laser. STUDY DESIGN/MATERIALS AND METHODS: Severe-to-moderate rhinophyma in six patients were treated at our institution between 1995 and 1996, using the Erbium:YAG (Erb:YAG) laser. RESULTS: All patients achieved marked cosmetic improvement, with no complications. Post-operative healing time was seven to fourteen days-significantly shorter than similar other modalities. CONCLUSIONS: The Erbium laser provides very accurate tissue ablation and allows the sculpturing of the hypertrophied areas, offering good cosmetic results, with a very short healing period as shown in our study.