Skin rejuvenation with microthermal fractional photothermolysis

ABSTRACT:  Fractional resurfacing is gaining acceptance as a preferred method for skin resurfacing. Experience in treating photoaging, acne scars, and melasma is reviewed.     

复合维生素E,C,B组合物面膜治疗寻常痤疮117例的疗效和安全性(英文)

目的:了解维生素E,C,B组合物面膜治疗寻常痤疮的疗效及安全性。方法:117例13a以上、痤疮严重程度分级在2级以上且主要表现于脸部的病人,予维生素E,C,B组合物面膜治疗,每日1次,共8wk。观察治疗前后痤疮数量及性质,包括粉刺、丘疹、脓疱及囊肿之数目,并评估整体疗效。结果:治疗后,粉刺、丘疹、脓疱及囊肿数目下降了13±s13,10±12,5±7及3±3,均P<0.01。7例(6.0%)病人症状完全改善,44例(37.6%)中度改善,56例(47.9%)轻度改善,10例(8.6%)无改善。59例(50.4%)病人无红肿、搔痒、灼热及脱皮等现象发生。结论:维生素E,C,B组合物面膜治疗痤疮有效,超过半数的受试者无不良反应发生,可作为传统治疗寻常痤疮药物的替代。     

The effectiveness of intermittent isotretinoin treatment in mild or moderate acne

BACKGROUND: Isotretinoin is the only drug that affects almost all factors in acne pathogenesis. Recently, its use for the treatment of chronic mild or moderate acne unresponsive to long-term antibiotic therapy, and with a tendency to cause scarring and leading to negative psychological effects, has became popular. The aim of the study was to investigate the effectiveness of intermittent isotretinoin treatment in mild or moderate acne. METHODS: Sixty patients with mild or moderate acne localized to the face were enrolled in the study. The treatment regimen consisted of isotretinoin, 0.5-0.75 mg/kg per day, applied for 1 week every 4 weeks for a total period of 6 months, according to the degree of acne and number of inflammatory lesions. RESULTS: Forty-one (68.3%) of the 60 patients completed the 6-month therapy. At the end of the treatment complete improvement was observed in 34 patients (82.9%) out of 41. All adverse effects were mild and discontinuation of the treatment was not necessary. CONCLUSION: Intermittent isotretinoin treatment was found to be a safe and effective choice for patients with mild or moderate acne.     

中西医结合治疗寻常性痤疮的临床观察

目的 :探讨中西医结合治疗寻常性痤疮的临床疗效。方法 :将 10 5例寻常性痤疮患者随机分为中西医结合治疗组和西药治疗对照组 ,分别应用中西药结合治疗和西药治疗 ,治疗后观察两组的临床疗效及皮损变化情况。结果 :中西医结合治疗组痊愈率、显效率及皮损消退情况显著高于西药治疗对照组 (P <0 .0 5 ,P <0 .0 1)。结论 :中西医结合治疗寻常性痤疮有较好的临床效果。     

新清宁胶囊治疗寻常型痤疮103例临床疗效观察

目的观察新清宁胶囊治疗寻常型痤疮的疗效。方法将209例患者随机分为治疗组(新清宁胶囊)和对照组(四环素片),并对服药30d后的疗效进行比较分析。结果治疗组治愈率为89.4%,与对照组相比较有显著差异,(X2=47.75,P<0.01)。结论新清宁胶囊是治疗寻常型痤疮的有效方法。     

Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement,Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized,Double-Blind,Placebo-Controlled Study

Lactobacillus plantarum CJLP55 has anti-pathogenic bacterial and anti-inflammatory activities in vitro. We investigated the dietary effect of CJLP55 supplement in patients with acne vulgaris, a prevalent inflammatory skin condition. Subjects ingested CJLP55 or placebo (n = 14 per group) supplements for 12 weeks in this double-blind, placebo-controlled randomized study. Acne lesion count and grade, skin sebum, hydration, pH and surface lipids were assessed. Metagenomic DNA analysis was performed on urine extracellular vesicles (EV), which indirectly reflect systemic bacterial flora. Compared to the placebo supplement, CJLP55 supplement improved acne lesion count and grade, decreased sebum triglycerides (TG), and increased hydration and ceramide 2, the major ceramide species that maintains the epidermal lipid barrier for hydration. In addition, CJLP55 supplement decreased the prevalence of Proteobacteria and increased Firmicutes, which were correlated with decreased TG, the major skin surface lipid of sebum origin. CJLP55 supplement further decreased the Bacteroidetes:Firmicutes ratio, a relevant marker of bacterial dysbiosis. No differences in skin pH, other skin surface lipids or urine bacterial EV phylum were noted between CJLP55 and placebo supplements. Dietary Lactobacillus plantarum CJLP55 was beneficial to clinical state, skin sebum, and hydration and urine bacterial EV phylum flora in patients with acne vulgaris.     

86例痤疮患者血清性激素水平分析

目的 研究痤疮患者血清性激素水平与痤疮的关系。方法 对86例痤疮患者以放免法检测患者血清睾酮、卵泡刺激素（男性称精子生成素）、黄体生成素（男性称间质细胞刺激素）、孕酮和雌二醇;并对其中20例患者检测了泌乳素。结果 男性寻常痤疮、男和女聚合性痤疮和痤疮伴四肢或乳晕多毛（女性）63．89％患者血清睾酮增高,75％患者雌二醇增高;男性疮疮90．91％患者精子生成素低于正常。结论 血清性激素水平与痤疮类型有关,在痤疮的发生、发展和持续状态中起重要作用。     

中国芦荟治疗寻常痤疮临床研究

目的：观察中国芦荟治疗寻常痊疮的疗效。方法：全叶组41例外用芦荟全叶，叶肉组40例外用芦荟叶肉，对照组30例外用达芙文凝胶治疗。结果：3组总有效率分别为73．2％，70．0％，76．7％，经统计学处理无显著性差异(P＞0．05)。结论：中国芦荟全叶和叶肉外用治疗寻常痊疮疗效较好，但叶肉更安全，患者依从性好。     

丹参酮胶囊治疗结节囊肿性痤疮的临床疗效评价

目的 :观察丹参酮治疗结节囊肿性痤疮的临床疗效。方法 :选择符合标准的一组患者 (共 3 5例 ,3 1例完成观察 ) ,口服丹参酮胶囊 (0 .2 5g 粒 ) ,每次4粒 ,每日 3次 ,连服 8wk后 ,改为每次 3粒 ,每日 3次 ,总疗程共 1 2wk。结果 :治疗的总有效率为83 .9% ,治疗 2、4、8、1 2wk后结节囊肿性皮损平均数目分别是 1 9± 9、1 5±6、1 0±6和 7± 7(P <0 .0 1 ) ,与治疗前 (2 3±1 1 )比较 ,P <0 .0 1。结论 :丹参酮对结节囊肿性痤疮有较好的临床疗效 ,随疗程的延长有效率逐渐增加     

疏风解毒胶囊联合环丙沙星与维生素C治疗肺风粉刺的临床观察

目的 评价疏风解毒方联合环丙沙星与维生素C治疗肺风粉刺的临床疗效和愈后。方法 将60例痤疮中医辨证为肺经风热型的患者随机分成治疗组与对照组各30例，对照组给予外用盐酸环丙沙星和口服VitC，治疗组在对照组的基础上同时给予疏风解毒胶囊，两组疗程均为1个月。两组分别在治疗2、4周时评价系统症状（口干、便秘等）和皮损炎症好转情况、新发皮损情况、愈后（出现色素沉着和凹陷性瘢痕）情况、临床总有效率，同时考察两组不良反应以评价其安全性。结果 两组治疗后临床疗效对比，治疗组总有效率为96.67%高于对照组的76.67%（P<0.05）。治疗两周后，治疗组口渴、便秘等系统症状减轻例数、皮损处红肿消退例数分别为26例、24例，对照组为4例、7例，治疗组的症状减轻人数明显多于对照组，差异有显著统计学意义（P<0.01）；且两周后治疗组有新发皮损数明显少于对照组，差异有显著统计学意义（P<0.01）。结论 疏风解毒方联合环丙沙星与维生素C在治疗痤疮肺经风热证上疗效显著，愈后理想。