肾炎清片对无症状性血尿患者IL-6和VEGF水平的影响

目的 探讨肾炎清片对无症状性血尿患者IL-6和VEGF水平的影响.方法 将76例临床诊断为无症状性血尿患者随机分为治疗组和对照组各38例,对照分析肾炎清片治疗前和治疗后无症状血尿患者的IL-6和VEGF的水平.结果 肾炎清片治疗组无症状性血尿患者的IL-6和VEGF的水平较对照组明显降低,结果显示组间的差异具有统计学意义(P＜0.05).结论 肾炎清片能够改变无症状性血尿患者IL-6和VEGF的水平,可能对无症状性血尿患者血尿症状的改善具有一定的作用.     

The Influence of Engravings on the Sticking of Tablets. Investigations with an Instrumented Upper Punch

The purpose of this study was to investigate the influence of engravings on the sticking of tablets. Therefore, an instrumented upper punch capable of measuring the pull-off force, which occurs when the punch detaches itself from the upper surface of a tablet, was equipped with small cones of different angles between the punch face and the cones’ lateral face. The cones could be screwed into a threaded hole at the center of the punch face. The adhesion forces of two formulations known to stick to engravings during production increased with a greater steepness of the cones’ lateral face. With microencapsulated acetylsalicylic acid, no quantitative differences could be found between the adhesion forces obtained with plain and modified punch faces, indicating that the sticking behavior of the substance was not affected by shear forces. Starch 1500® showed higher adhesion force signals in comparison to those obtained with a plain punch face. Microcrystalline cellulose, which gave no adhesion force signals with a plain punch face and did not stick to the cones, showed distinct pull-off signals. The instrumented upper punch equipped with shear cones is a valuable instrument for detecting the adhesion caused by engravings and is therefore a helpful tool for tablet formulation development and the design optimization of tablet identification.     

高效液相色谱法测定复方丹参片的三七皂苷R1含量

目的用高效液相色谱（HPLC）法测定复方丹参片的三七皂苷R1含量。方法色谱柱为Thermo C18柱（250mm×4．6mm，5μm），以乙腈-水（20：80）为流动相，检测波长为203nm，枉温为30℃。结果三七皂苷R1进样量在0．3～2．5μg范围内与峰面积线性关系良好，平均加样回收率为97．58％，RSD=0．9％（n=6）。结论HPLC法简便可行、重现性好，可以用于复方丹参片的质量控制。     

红金消结片的制备与质量控制

目的:研究红金消结片的制备及其质量控制方法.方法:鉴别采用薄层色谱法,用高效液相色谱法测定人参皂苷Rg1含量.色谱柱为Cmsmosil C18(200mm×4.6mm,5μm),乙腈-0.05%磷酸溶液(21:79)为流动相;检测波长为203nm,柱温为25℃.结果:红金消结片中人参皂苷Rg1在0.7～6.3μg呈良好线性关系,r=0.999 2.结论:红金消结片制备工艺简单,质量控制方法可靠,重现性好.     

热痹通片联合伤科黄水治疗急性痛风性关节炎的临床研究

目的观察热痹通片联合伤科黄水治疗急性痛风性关节炎的临床疗效。方法将80例患者随机分为两组,两组基础治疗相同。治疗组口服热痹通片、外敷伤科黄水治疗;对照组给予秋水仙碱、扶他林治疗。疗程均为7 d。结果治疗组的临床疗效与对照组相当,两组治疗后血沉(ESR)、C反应蛋白(CRP)改善无差异,治疗组降血尿酸(BUA)优于对照组。结论热痹通片联合伤科黄水治疗急性痛风性关节炎的疗效满意。     

妇科止带片质量标准研究

目的提高妇科止带片的质量标准。方法用薄层色谱法鉴别椿皮、五味予，用高效液相色谱（HPLC）法测定盐酸小檗碱含量。结果方法平均回收率为99．31％，RSD为1．00％。结论定性、定量方法简便，准确，专属性强，可以更有效地控制妇科止带片的质量。     

正清风痛宁片含量测定方法改进

目的:采用HPLC法测定正清风痛宁片中青藤碱含量。方法:色谱条件为:采用Kromasil-C_(18)柱,以乙腈-0.78%磷酸二氢钠溶液(12:88)为流动相;检测波长:265nm;流速1ml·min~(-1);柱温:30℃。结果:青藤碱在0.38～1.92μg范围内具有良好的线性关系,r=0.9999。平均回收率为98.3%,RSD=0.8%。结论:本法操作简单,重复性好,准确,可用来控制本制剂质量。     

反相高效液相色谱法同时测定四维钙片中多种维生素含量

目的对四维钙片中的维生素C（VitC）、维生素B1（vitB1）及维生素B2（VitB2）进行含量测定。方法采用反相高效液相色谱法，使用Zorbax Eclipse XDB—C8柱（150mm×4．6mm，5μm），流动相为0．05％乙酸溶液（含0．005mol／L己烷磺酸钠、1．3％三乙胺，用冰醋酸调节pH值至3．5）-甲醇（90：lO），检测波长为254nm。结果VitC，VitB1，，VitB2质量浓度分别在7～60μg／mL，1～10μg／mL，1～10μg／mL范围内与峰面积线性关系良好，r分别为0．9998，0．9997，0．9998（n=8）；平均回收率分别为100．3％，99．1％，98．5％，RSD分别为1．2％．1．5％．1．6％（n=9）。结论该方法准确、简单,能够有效控制制剂的质量。     

复方甘草口含片处方及制备工艺研究

目的考察及筛选复方甘草口含片的处方和制备工艺。方法以有效成分和口感为考察指标，对辅料进行优选。结果确定了以β-环糊精掩盖特殊恶臭味的复方甘草口含片的处方及工艺。结论确定的复方甘草口含片处方合理，制备工艺可行且能够适应大规模工业生产的要求。     

Figures of Merit Comparison of Reflectance and Transmittance Near-Infrared Methods for the Prediction of Constituent Concentrations in Pharmaceutical Compacts

The purpose of this work was to demonstrate how multivariate figures of merit, in conjunction with accuracy and precision statistics, can be used to evaluate the performance of near-infrared reflectance and transmittance spectroscopy for the nondestructive chemical quantification of intact pharmaceutical compacts. A total of 174 four-component compacts were produced at five compaction pressures following a fully balanced quaternary design. Near-infrared spectra were measured in both reflectance and transmittance modes. Partial least-squares regression was used to model spectroscopic response, and net analyte signal theory was used to generate the figures of merit. It was discovered that sample positioning variation more negatively impacted the performance (analytical sensitivity, S/N ratio, limit of detection) of the transmittance method. Process analytical technology implementation teams should consider these aspects during technology selection, method development, and validation.