全文获取类型
收费全文 | 62765篇 |
免费 | 4896篇 |
国内免费 | 1215篇 |
专业分类
耳鼻咽喉 | 312篇 |
儿科学 | 3628篇 |
妇产科学 | 1496篇 |
基础医学 | 8077篇 |
口腔科学 | 1403篇 |
临床医学 | 4280篇 |
内科学 | 11811篇 |
皮肤病学 | 883篇 |
神经病学 | 4319篇 |
特种医学 | 2181篇 |
外国民族医学 | 5篇 |
外科学 | 7035篇 |
综合类 | 5911篇 |
现状与发展 | 5篇 |
预防医学 | 4817篇 |
眼科学 | 703篇 |
药学 | 5032篇 |
37篇 | |
中国医学 | 4592篇 |
肿瘤学 | 2349篇 |
出版年
2023年 | 907篇 |
2022年 | 1479篇 |
2021年 | 2903篇 |
2020年 | 2445篇 |
2019年 | 3167篇 |
2018年 | 3089篇 |
2017年 | 2462篇 |
2016年 | 2007篇 |
2015年 | 1931篇 |
2014年 | 3424篇 |
2013年 | 3398篇 |
2012年 | 2565篇 |
2011年 | 2736篇 |
2010年 | 2164篇 |
2009年 | 2234篇 |
2008年 | 1999篇 |
2007年 | 1983篇 |
2006年 | 1844篇 |
2005年 | 1525篇 |
2004年 | 1394篇 |
2003年 | 1302篇 |
2002年 | 1004篇 |
2001年 | 957篇 |
2000年 | 873篇 |
1999年 | 805篇 |
1998年 | 700篇 |
1997年 | 608篇 |
1996年 | 508篇 |
1995年 | 481篇 |
1994年 | 411篇 |
1993年 | 353篇 |
1992年 | 315篇 |
1991年 | 339篇 |
1990年 | 285篇 |
1989年 | 266篇 |
1988年 | 264篇 |
1987年 | 204篇 |
1985年 | 1183篇 |
1984年 | 1936篇 |
1983年 | 1191篇 |
1982年 | 1350篇 |
1981年 | 1293篇 |
1980年 | 1061篇 |
1979年 | 977篇 |
1978年 | 850篇 |
1977年 | 733篇 |
1976年 | 842篇 |
1975年 | 588篇 |
1974年 | 519篇 |
1973年 | 585篇 |
排序方式: 共有10000条查询结果,搜索用时 125 毫秒
51.
John P. Sundberg Kathleen A. Silva Victoria E. Kennedy John J. Wilson Nicholas E. Gott Beth A. Sundberg Derry C. Roopenian 《Experimental dermatology》2019,28(9):1091-1093
2‐deoxy D‐glucose (2DG) was tested for efficacy in treating alopecia areata using the C3H/HeJ skin graft model. 2DG has proven to be efficacious in treatment of various mouse models of autoimmunity with minimal serious side effects noted. This agent has been shown to normalize abnormally activated T‐cell populations while also preventing cell surface expression of NKG2D; key factors defining alopecia areata disease progression. Daily oral ingestion of 2DG via drinking water to mice with patchy or diffuse alopecia areata for 16 weeks failed to prevent expansion of alopecia or cause regrowth of hair in treated mice. Histologically, there were no differences between treated and control groups. These results indicate that, while 2DG is effective for some autoimmune diseases, it was not efficacious for the cell‐mediated autoimmune mouse disease, alopecia areata. 相似文献
52.
Hong-Mei LiBohan LiHui MaXiaolong SunMeilin ZhuYiqun DaiTao MaQiang HuoCheng-Zhu Wu 《Asian Pacific journal of cancer prevention》2020,21(4):1073-1080
Objective: A dimeric neolignan, bishonokiol A (BHNKA) isolated from Magnolia grandiflora, significantly inhibits the proliferation of human breast cancer cells. However, the exact mechanism of BHNKA induced breast cancer cell death is unknown. In this study, we investigated the pharmacological mechanism underlying BHNKA induced MCF-7 cell death. Methods: Cell viability measurement was performed by the MTT assay. Flow cytometry with PI staining, DAPI staining, and electron microscopy were used to analyze cellular death modes. In addition, western blotting, siRNA transfection, ATP assay, and fluorescence microscopy were used to determine the mechanism of BHNKA induced MCF-7 cell death. Results: BHNKA induced cell death by apoptosis, necroptosis and autophagy at the same concentration and time in MCF-7 cells, and electron microscopy confirmed these results. The mechanism of BHNKA triggered apoptosis and autophagy in MCF-7 cells was primarily due to an increase in the Bax/Bcl-2 ratio and simultaneous up-regulation of LC3-II protein expression, respectively. BHNKA induced necroptosis by activation of the RIP1-RIP3-MLKL necroptosis cascade, up-regulation of cyclophilin D (CypD) protein expression to stimulate ROS generation. We further demonstrated that siRNA-mediated down-regulation of CypD protected against BHNKA induced cell death. Conclusions: These results suggest that BHNKA may be a potential lead compound for development as an anti-breast cancer agent for induction of multiple cell death pathways. 相似文献
53.
54.
55.
Lilia Bliznashka Joanne E. Arsenault Elodie Becquey Marie T. Ruel Deanna K. Olney 《Maternal & child nutrition》2020,16(1)
Anaemia is a persistent problem among young Burkinabe children, yet population‐specific information on its determinants is scant. We used baseline data from an evaluation of Helen Keller International's Enhanced Homestead Food Production Program (n=1210 children) to quantify household‐, mother‐, and child‐level factors associated with anaemia in Burkinabe children aged 6‐12 months. We used structural equation modelling to assess a theoretical model, which tested four categories of factors: (a) household food security and dietary diversity, (b) household sanitation and hygiene (latrine and poultry access and bednet ownership), (c) maternal factors (anaemia, stress, cleanliness, and health, hygiene and feeding knowledge and practices), and (d) child nutrition and health (iron deficiency (ID), retinol binding protein (RBP), malaria, and inflammation). The model also included household socio‐economic status, size, and polygamy; maternal age and education; and child age and sex. Results showed that ID, malaria, and inflammation were the primary direct determinants of anaemia, contributing 15%, 10%, and 10%, respectively. Maternal knowledge directly explained improved child feeding practices and household bednet ownership. Household dietary diversity directly explained 18% of child feeding practices. Additionally, RBP, child age and sex, and maternal anaemia directly predicted child haemoglobin. Our findings suggest that program effectiveness could be increased by addressing the multiple, context‐specific contributors of child anaemia. For young Burkinabe children, anaemia control programs that include interventions to reduce ID, malaria, and inflammation should be tested. Other potential intervention entry points suggested by our model include improving maternal knowledge of optimal health, hygiene, and nutrition practices and household dietary diversity. 相似文献
56.
Kyung Won Lee Mi Sook Cho Dayeon Shin 《International journal of food sciences and nutrition》2016,67(2):184-194
Urinary iodine concentrations (UICs) in the US have been reported to be stable since 1988–1994, although those in selected subgroups remained low. We aimed to investigate iodine status among adults (≥20 years) by two different criteria of assessing iodine deficiency in population. Utilizing National Health and Nutrition Examination Surveys 2001–2012, we conducted linear logistic regressions adjusting for covariates. The prevalence of <50?μg/L UIC was higher in women than in men; increased from 11.6% (2001–2004) to 13.2% (2009–2012) at the national level and in young adults, non-Hispanic blacks (NHBs) and non-users of iodine-containing supplements (all, p?<0.05); the adjusted odds ratios (95%CI) in young adults (1.54 [1.11–2.15], p =?0.0007) and NHBs (1.70 [1.15–2.52], p =?0.0078). Median UICs confirm women and NHBs being in borderline iodine status. Recognizing the critical consequence of iodine deficiency particularly in women and NHBs, regular monitoring of iodine status is important for public health in the US. 相似文献
57.
58.
Ming-Yeh Yang Ching-Yuan Huang Tina H.T. Chiu Kai-Chih Chang Ming-Nan Lin Liang-Yü Chen Anren Hu 《Yao wu shi pin fen xi = Journal of food and drug analysis.》2019,27(2):494-501
Vitamin D is responsible for multiple metabolic functions in humans. Rickets are the most common disease caused by vitamin D deficiency. It is caused by poor calcium intake resulting in poor serum-ionized calcium. The purpose of this study is to develop a rapid, sensitive, and feasible method to determine the 25-hydroxy-vitamin D3 (25(OH)D3) levels in blood samples for clinical assessment. In this study, gas chromatography coupled mass spectrometry with trimethylsilyl derivatization (TMS-GC-MS) is the most suitable protocol for quantitative analyses of 25(OH)D3. Performance of method was evaluated and compared with liquid chromatography and immunoassay. Method validation has been carried out with plasma specimens. The limit of quantitation of TMS-GC-MS method is 1.5 ppb with good linear correlation. Furthermore, the dietary intake and nutritional status of vegetarian and non-vegetarians in Taiwan were assessed by our validated method. As a result, this vitamin D nutrition survey demonstrates that most Taiwanese people have insufficient vitamin D. Due to dietary habits; the male vegans may have the highest risk of vitamin D deficiency. 相似文献
59.
60.
《Journal of Clinical Orthopaedics and Trauma》2019,10(2):380-386
Additive manufacturing is a rapidly emerging technology which is being successfully implemented in the various field of medicine as well as in orthopaedics, where it has applications in reducing cartilage defects and treatments of bones. The technology helps through systematic collection of information about the shape of the "defects" and precise fabrication of complex 3D constructs such as cartilage, heart valve, trachea, myocardial bone tissue and blood vessels. In this paper, a large number of the relevant research papers on the additive manufacturing and its application in medical specifically orthopaedics are identified through Scopus had been studied using Bibliometric analysis and application analysis is undertaken. The bibliometric analysis shows that there is an increasing trend in the research reports on additive manufacturing applications in the field of orthopaedics. Discussions are on using technological advancement like scanning techniques and various challenges of the orthopaedic being met by additive manufacturing technology. For patient-specific orthopaedic applications, these techniques incorporate clinical practice and use for effective planning. 3D printed models printed by this technology are accepted for orthopaedic surgery such as revision of lumbar discectomy, pelvic surgery and large scapular osteochondroma. The applications of additive manufacturing in orthopaedics will experience a rapid translation in future. An orthopaedic surgeon can convert need/idea into a reality by using computer-aided design (CAD) software, analysis software to facilitate the manufacturing. Thus, AM provides a comprehensive opportunity to manufacture orthopaedic implantable medical devices. 相似文献