肾阳亏虚证泄泻的现代生物学内涵

肾阳亏虚证作为泄泻常见中医证型,其发病机制较为复杂.本文从肠道菌群、信号通路、“肾-肠轴”相关分子三个层面探究肾阳亏虚证泄泻发生发展的作用机制,寻找肾阳亏虚证泄泻的生物标记物,对揭示肾阳亏虚证泄泻的现代生物学内涵以及推进后续临床的靶向治疗具有重要意义.     

“四个全面”战略布局的形成、内涵与定位

党的十八大以来,以习近平同志为总书记的新一届中央领导集体从坚持和发展中国特色社会主义全局出发,提出和确立了协调推进全面建成小康社会、全面深化改革、全面依法治国、全面从严治党的战略布局,形成了“四个全面”战略思想,开辟了中国共产党治国理政的新境界,实现了马克思主义与中国实际相结合的新飞跃,是中国特色社会主义理论体系的最新成果。在“四个全面”战略布局中,既有战略目标,也有战略举措,其中每一个“全面”都具有重大战略意义,都有其历史形成过程和深刻而丰富的科学内涵。系统考察其形成过程,深刻把握其基本内涵,正确认识其科学定位,对正确理解把握和深入贯彻落实“四个全面”战略布局,具有重要意义。     

医院网络中的安全风险与防范措施

随着信息科技的高速发展,网络在越来越多地为人们生活提供便利的同时,也为企业节省了大量的人力和物力,但是企业在使用网络与外界交流时也同样承担着巨大的风险。本文介绍了医院网络中存在风险的原因、存在的风险及其对策。为医院在网络安全方面提供了一定的建议。     

基于发明专利的全球心室辅助装置技术创新态势研究

目的:研究全球心室辅助装置(VAD)领域的发明专利,分析揭示技术创新态势,为VAD领域的研发提供信息支撑.方法:采用专利分析方法,从技术创新时间趋势、技术创新热点、技术创新国家和地区以及主要竞争对手等角度,对智慧芽专利数据库收录的VAD发明专利进行分析,揭示VAD领域的发展态势.结果:VAD领域目前共有发明专利申请11...     

A longitudinal study on the Ghislenghien disaster in Belgium: strengths and weaknesses of the study design and influence on response rate

Background

A longitudinal study was conducted in order to assess the impact of the Ghislenghien disaster (Belgium) on physical, mental and social health, and to evaluate the prevalence of Post-Traumatic Stress Disorder (PTSD) in the affected population.

Objectives

To describe the set up of the study, to report on the strengths and weaknesses of the methodology employed and its influence on response rate. To clarify the importance of the study for the management of disasters.

Methods/Design

The study included adults (≥ 15 years) and children (8-14 years) at risk of developing adverse health effects related to the disaster. Subjects were connected to the disaster through their geographical or professional proximity as well as connections through relatives. Questionnaires were sent by regular mail 5 months and 14 months after the disaster. Pearson Chi square tests were used to investigate whether the response rate at 14 months depended on the exposure classification.

Results

The response rate at household level was respectively 18% (n = 607 families) and 56% (n = 338 families) 5 months and 14 months after the disaster. Response rate at the follow up period did not significantly differ by exposure classification.

Discussion

This paper discusses the difficulties and challenges encountered during the design of the study. It discusses the determinants of response in relation to disaster related characteristics. It further provides an overview of lessons learnt and the significance of the study for the management of large scale emergencies.

     

衰老视角阐释膝骨关节炎虚实夹杂病机的科学内涵

膝骨关节炎是骨伤科常见的退行性疾病，症状以膝关节疼痛、肿胀、活动受限为主。既往中医并无关节炎病名，对此病的认识多依据症状，早期归入“痹证”“膝痹”，后期归入“痿证”范畴。病因病机方面总体认为本病属于本虚标实，本虚主要是肝肾不足、气血亏虚，标实主要是气血痹阻、寒凝痰结等。因此，在治法方面，各家经验虽然治法、用药不一，但多数强调治法的攻补兼施。膝骨关节炎本质上是骨关节的衰老，结合中医对于衰老的认识，以及现代医学对于组织细胞衰老的认识，从细胞衰老及其在组织间扩散的机制认识膝骨关节炎“虚实夹杂”的科学内涵，对临床和科研具有启发性意义。     

试谈对《千金方》知识层面的研究

主要讨论从知识层面研究《千金方》学术内涵的必要性和可行性,认为借助知识解析的理念与方法,可以最大限度地发现《千金方》中蕴涵的知识,反映当时中医学术在知识层面的科学内涵。     

南京总医院10年获奖成果回顾

目的：总结我院近10年511项获奖成果的经验。方法与结果：采用回顾性分析方法,对获奖成果从学历、职称、学科建设等方面进行深入分析,发现成果奖获得与高学历、学科建设、学科带头人密切相关。重大成果奖成绩突出,大奖与小奖数量差别合理;奖项等级越高,成果创新程度越大,科学性越强;数量虽少,却是“精品”,说明潜能巨大。结论：科技人员在科技政策指引下,积极参与科研工作。让创新思维多出成果,使管理产生效益,科研政策兑现,成果数质量在各大军区（军兵种）总医院中位居前列。     

Duties and responsibilities of laboratory scientists

The duties and responsibilities of laboratory scientists are still evolving. In this paper, I briefly summarize some of the classical duties and responsibilities of Clinical Chemists in the areas of research, education and service. Furthermore, I developed some general rules of success for younger laboratorians. It is clear that we are living in exciting times and Clinical Chemists must learn to adapt very quickly to the continuing changes in our discipline. The new developments in science and technology suggest that we are yet to realize the best times of this exciting profession.