对碘缺乏病区7～9岁学生投服碘油胶丸的防治效果研究

对已供碘盐的碘缺乏病区的７～９岁学生加服不同剂量的碘油胶丸，以研究对这一组人群的补碘途径和方法。结果显示，投药１年和２年后投药组与对照组的甲状腺肿大率、学习成绩、体育成绩和尿碘值之间有极显著差异。且投药后第１年、第２年０．４ｇ组尿碘值明显高于０．２ｇ组，第２年甲状腺肿大率则反之。但２年中三组身高、体重，胸围之间差异无显著性。因此，对这一组人群的防治方法为每年口服０．２ｇ碘油胶丸１次或２年口服０．４ｇ碘油胶丸一次。     

ClinicalObservationofQiDeficiencySyndromein72PatientswithChronicObstructivePulmonaryDiseaseTreatedwithYiqiMianyiGranule（益气免疫冲

ＣｌｉｎｉｃａｌＯｂｓｅｒｖａｔｉｏｎｏｆＱｉＤｅｆｉｃｉｅｎｃｙＳｙｎｄｒｏｍｅｉｎ７２ＰａｔｉｅｎｔｓｗｉｔｈＣｈｒｏｎｉｃＯｂｓｔｒｕｃｔｉｖｅＰｕｌｍｏｎａｒｙＤｉｓｅａｓｅＴｒｅａｔｅｄｗｉｔｈＹｉｑｉＭｉａｎｙｉＧｒａｎｕｌｅ（益气免疫冲...     

《理虚元鉴》辨证论治特色

汪绮石《理虚元鉴》证治虚证重“三本二统”;辨证强调未详五脏,先审七情;论治注重未病先防,已病重调;投方用药有新解特色。     

益气健脾法干预乳腺癌患者化疗所致脾虚证的临床研究

目的:评价益气健脾法干预乳腺癌患者化疗所致脾虚证的影响。方法:30例女性乳腺癌化疗病人随机分单纯化疗、化疗前中药和化疗后中药3组,用益气健脾法中药干预,研究观察各组治疗前后脾虚证积分、血象及T细胞亚群变化。结果:3组化疗后脾虚积分均有升高,以单纯化疗组最明显(P<0.05),中药干预两组差异不明显(P>0.05);单纯化疗组60%(6/10)出现III度血液毒性,化疗后中药组10%(1/10)出现III度血液毒性而化疗后中药组未出现III度血液毒性病例;T细胞亚群:化疗前后辅助性T细胞(CD4 )及CD4 /CD8 比值单纯化疗组有明显下降(P(0.05);中药干预两组反有上升(P(0.05)。结论:抗肿瘤化疗药物可影响中医证侯,使肿瘤患者出现或加重脾虚证,益气健脾中药干预可减轻或改善患者脾虚证,减轻化疗毒副反应。使CD4 /CD 比值向CD 方向漂移,增强机体免疫能力。     

低硒与低营养复合因素致大鼠心肌损伤的实验研究

目的 探讨长期低硒与低营养复合因素膳食对大鼠心肌损伤的作用。方法 将Wistar大鼠40只随机分成2组，实验组用低硒、低蛋白、低维生素E饲料喂养，对照组用常硒、常蛋白、常维生素E饲料喂养，至第26周处死大鼠。测定全血谷胱甘肽过氧化物酶（GSH-Px）活性，血清肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）水平和心脏质量与体质量比值。光镜、电镜下观察心肌结构改变。结果 实验组大鼠全血GSH墩活性水平显著低于对照组（t=58．79，P〈0．01）；实验组与对照组大鼠血清CK分别为（1．456±0．291）、（1．057±0．251）kU／L，CK—MB分别为（1．138±0．215）、（0．722±0．130）kU／L，LDH分别为（864．96±137．57）、（404．65±72．49）U／L，组间比较差异有统计学意义（t=4．71、7．46、13.42，P〈0．01）。大鼠心脏质量与体质量比值，实验组[（3．608±0．166）g／kg]显著高于对照组[（3．140±0．114）g／kg]，组间比较差异有统计学意义（t=10．62，P〈0．01）。光镜下实验组大鼠心肌出现散在小灶状坏死，检出率为66．67％，两组心肌病变检出率差异有统计学意义（χ^2=7．25，P〈0．01）。电镜下实验组大鼠部分心肌细胞线粒体嵴断裂，基质密度下降，细胞核固缩，早期凋亡形成，肌丝走行紊乱甚至溶解；对照组大鼠心肌细胞膜结构完好，线粒体嵴清晰，基质密度适中。结论 长期低硒、低营养复合因素膳食可引起大鼠心肌组织出现损伤。     

消除碘缺乏病20年综合干预效果的分析

目的了解20年综合防治后光泽县地方性克汀病防治效果。方法采用PPS抽样法和随机整群抽样法进行调查。结果儿童甲状腺肿大率从防治前的56.41%下降到3.92%,尿碘中位数306.5μg/L,居民碘盐覆盖率为96.11%,合格碘盐食用率为90.28%,供应碘盐第二年后未再出现新发的地方性克汀病病人。结论光泽县碘盐合格率、儿童的尿碘水平和甲状腺肿大率等指标均达到了消除碘缺乏病的标准,并实现了消除地方性克汀病的预期目的。     

2005年河南省碘缺乏病监测结果分析

目的调查河南省碘缺乏病防治现状，完善可持续防治策略。方法采用人121比例概率抽样法（PPS）分阶段抽样。全省抽取30个县的8～10岁学生1200名，检查甲状腺肿大情况、测验智商、检测尿碘及家中盐样含碘量，并在学生和家庭主妇中进行健康教育问卷调查。结果①全省盐碘均值为29．18mg／kg，碘盐覆盖率为97．67％。②8-10岁学生甲状腺肿大率触诊法为4．56％，B超法为2．75％；智商均值为95．5，标准差为16.3。③检测8-10岁儿童尿样358份，尿碘中位数为315．30斗g／C。④问卷调查602名学生碘缺乏病防治知识，平均分为57．9分，及格率为35．5％。⑤在普及碘盐供应10年后，原划定病区与非病区间儿童甲状腺肿大率（B超法）差异无统计学意义（P〉0．05）；智商、盐碘、尿碘间差异亦无统计学意义（P〉0．05）。结论①河南省目前各项防治指标达到了碘缺乏病消除标准，但学龄儿童尿碘中位数较高，可以考虑适当下调碘盐含碘量；②儿童智商低下者（智商≤69）仍然高达7.3％，需要加强对孕妇的重点监测，早期发现缺碘，早期补碘；③防治知识知晓率偏低．应加强健康教育工作，增强群众防病意识。     

The Correlation Between Perceived Social Support and Illness Uncertainty in People with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome in Iran

Background:

Illness uncertainty is a source of a chronic and pervasive psychological stress for people living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) (PLWH), and largely affects their quality of life and the ability to cope with the disease. Based on the uncertainty in illness theory, the social support is one of the illness uncertainty antecedents, and influences the level of uncertainty perceived by patients.

Aim:

To examine uncertainty in PLWH and its correlation with social support in Iran.

Materials and Methods:

This cross-sectional correlational study was conducted with 80 PLWH presenting to AIDS Research Center, Tehran, Iran in 2013. The data collected using illness uncertainty and social support inventories were analyzed through Pearson''s correlation coefficient, Spearman''s correlation coefficient, and regression analysis.

Results:

The results showed a high level of illness uncertainty in PLWH and a negative significant correlation between perceived social support and illness uncertainty (P = 0.01, r = -0.29).

Conclusion:

Uncertainty is a serious aspect of illness experience in Iranian PLWH. Providing adequate, structured information to patients as well as opportunities to discuss their concerns with other PLWH and receive emotional support from their health care providers may be worthwhile.     

Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency

In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. In order to address this particular question, we used a TD rat model and patch-clamp technique to investigate the electrical properties of isolated cardiomyocytes from epicardium and endocardium. Neither cell type showed substantial differences on the action potential waveform and transient outward potassium current. Based on our results we can conclude that TD does not induce major electrical remodeling in isolated cardiac myocytes in either endocardium or epicardium cells.