特殊疾病医疗保险对糖尿病患者治疗费用的影响及相关因素分析

目的比较重庆市已纳入慢病管理系统2型糖尿病患者中，有、无特殊疾病医疗保险（简称特病医保）者之间的治疗费用情况及可能影响申请该特病医保的因素。方法采用结构化问卷，调查患者的基本信息及与糖尿病有关的药房、门诊、住院治疗费用情况。使用SAS 9.1软件进行数据统计分析，计数资料分析采用 χ ²检验，有统计学差异的变量再纳入多因素逐步logistic回归模型。连续性变量用中位数（四分位数间距）[ M（ Q）]来表示，采用Wilcoxon秩和检验。 结果门诊组有特病医保的患者年人均总费用[2160（3081）元]较无特病医保的患者高[1000（2100）元， P < 0.01]，年次均自费比例（54.04%）低于无特病医保患者的自费比例（93.78%， P < 0.01）。就申请特病医保而言，中等收入水平（ OR=1.94）、高收入水平（ OR=2.11）、参加城镇职工医疗保险（ OR=4.19）、病程超过5年（ OR=2.04）都是其可能的影响因素，具有这些特征的患者相对更容易申请到特病医保。 结论为缓解2型糖尿病患者经济负担，政府应大力宣传特病医保的相关政策，鼓励患者主动了解，积极申报。同时，医保部门与医疗机构应加强监管，简化办理流程，建议增加特殊疾病定点零售药店的数量和覆盖面，提高特病医保利用的可及性。同时，应更加关注低收入人群和病程相对较短的患者，增强他们抵御疾病经济风险的能力，提高特病医保的利用及公平性。     

Focusing on functional knee parameter determination to develop a better clinical gait analysis protocol

BackgroundAttempts to improve protocol standards of marker-based clinical gait analysis (CGA) have been one of the main focuses of research to enhance robustness and reliability outcomes since the 1990s. Determining joint centres and axes constitutes an important aspect of those protocols. Although the hip joint is more prominent in such studies, knee joint center (KJC) and axis (KJA) directly affect all outcomes.Research questionWhat recommendations arise from the study of the scientific literature for determining knee joint parameters (KJP) for protocols of CGA?MethodsA systematic, electronic search was conducted on November 2018 using three databases with the keyword combination (“functional approach” OR “functional method” OR “functional calibration”) AND (“hip joint” OR “knee joint” OR “ankle joint”) and analyzed by four reviewers. Given the existence of a recent review about the hip joint and the lack of material about the ankle joint, only papers about the knee joint were kept. The references cited in the selected papers were also screened in the final round of the search for these publications.The quality of the selected papers was assessed and aspects regarding accuracy, repeatability, and feasibility were thoroughly considered to allow for a comparison between studies. Technical aspects, such as marker set choice, KJP determination techniques, demographics, and functional movements, were also included.ResultsThirty-one papers were included and on average received a rating of about 75 % according to the quality scale used. The results showed that functional methods are superior or equivalent to predictive methods to estimate the KJA, while a regression method was slightly better for KJC prediction.SignificanceCalibration methods should be applied to CGA whenever feasibility is reached. No study to date has focused on evaluating the in vivo RoM required to obtain reliable and repeatable results and future work should aim in this direction.     

基于结构方程模型构建护理本科生人文关怀对职业精神态度的影响模式

目的 应用结构方程模型构建人文关怀对职业精神态度的影响模式,了解人文关怀、社会支持及职业精神态度之间的关系。方法 采用分层随机整群抽样法从南京和南通两所高等护理院校抽取全日制在校护理本科一年级至三年级在校学生450名进行问卷调查,应用AMOS 21.0构建人文关怀对职业精神态度的影响模式。 结果 人文关怀对职业精神态度影响模式的结构方程模型最终模型适配度指标分别为RMSEA = 0. 066、GFI = 0. 951、AGFI = 0. 918、NFI = 0. 901、ＲFI = 0. 860、IFI = 0. 932、TLI = 0. 903、CFI = 0. 931、PGFI = 0. 573、PNFI = 0.641、PCFI = 0. 663、χ_²/DF=2.965,说明模型拟合效果较好；人文关怀对社会支持的直接效应为0.571,社会支持对职业精神态度的直接效应为0.778,人文关怀对职业精神态度的总效应为0.554。结论 此模型可用于护生职业精神态度评价与干预工作,进一步提高护生人文关怀能力、社会支持水平及职业精神态度水平。     

A benchmark dose study of prenatal exposure to di(2-ethylhexyl) phthalate and behavioral problems in children

IntroductionPrenatal exposure to di(2-ethylhexyl) phthalate (DEHP) has been reported to be associated with adverse effects on neurodevelopment that yield behavior syndromes in young children with an estimated median exposure lower than the currently recommended tolerable daily intake (TDI) and reference dose (RfD).ObjectivesOur aim was to derive the benchmark dose for prenatal exposure to DEHP for the neurodevelopmental health in children.MethodsA total of 122 mother-child pairs from the Taiwan Maternal and Infant Cohort Study were analyzed for the dose-response relationship between maternal exposure to DEHP and children's behavioral syndromes evaluated at 8 years (n = 122, 2009), 11 years (n = 96, 2012), and 14 years (n = 78, 2015) of age. We employed a multivariate regression model to assess the statistical associations between the estimated maternal average daily intake of DEHP and child's individual CBCL scores for boys and girls at each separate age, followed by a mixed model for all the children across three ages accounting for individual variations. We then employed structural equation models by combining the children's specific behavioral problem scores at different ages and obtained a simulated overall latent score in relation to maternal exposure. Based on the established dose-response relationship, we derived the benchmark dose (BMD) and the lower limit (BMDL).ResultsAssociations of maternal DEHP exposure (median 4.54$\mu g/kg\_bw/day$) with the Child Behavior Checklist (CBCL) scores were all significant, except for somatic complaints, adjusting for child's age, gender, IQ, and family income. The BMDL, given a benchmark response of 0.10 (0.05) and a background response of 0.05, was 6.01 (2.16) $\mu g/kg\_bw/day$for an integrated CBCL score.ConclusionsThe current TDI (RfD) of 50 (20) $\mu g/kg\_bw/day$ for DEHP might not protect pregnant women for their children from behavioral problems. There remains the lack of comparable toxicological data. Further investigations are needed.     

Estimating the contribution of influenza to hospitalisations in New Zealand from 1994 to 2008

BackgroundInfluenza has a substantially but poorly measured impact on population health. Estimating its true contribution to hospitalisations remains a challenge.MethodsWe used simple and comprehensive negative binomial regression models with weekly counts of hospitalisations and isolates of influenza A, B and respiratory syncytial virus for the period 1994– 2008.ResultsThe estimated annual national average number of hospitalisations attributable to influenza was 822.1(95% CI: 815.3, 828.9) for pneumonia and influenza, 1861.3 (95% CI: 1842.9, 1879.7) for respiratory illness, 12.1 (95% CI: 2.6, 21.6) for circulatory illness, 2260.0 (95% CI: 2212.2, 2307.8) for all medical illness and 2419.9 (95% CI: 2356.4, 2483.4) for all causes. The contribution of influenza to total hospitalisations was about nine times larger than indicated by routine discharge data. New Zealanders 80 years of age and older had the highest annual excess rates of influenza-related hospitalisations (327.8 per 100,000); followed by infants under 1 year (244.5 per 100,000). Estimated influenza hospitalisation rates were also markedly higher in Pacific (83.3 per 100,000) and Māori (80.0 per 100,000) compared with European/Others (58.1 per 100,000).Respiratory illness was the major contributor to all cause hospitalisations attributed to influenza accounting for 77%. Influenza hospitalisations included only a negligible contribution from circulatory illness.ConclusionThese findings support efforts to reduce the impact of influenza, particularly for the most vulnerable population groups highlighted here. Analysis of the cost-effectiveness of such interventions needs to consider these higher modelled estimates of disease impact.     

基于结构方程模型的护理本科生自主学习能力影响因素研究

目的探讨护理本科生心理自立水平、评判性思维倾向、教育环境认知对其自主学习能力的影响,并建立其作用关系模型。方法采用一般资料问卷、护理学生自主学习能力量表、中文版加利福利亚评判性思维倾向调查表、大学生心理自立问卷和医学教育环境量表对湖南省11所护理院校的885名护理本科生进行调查。结果教育环境、心理自立、评判性思维倾向均可直接正性影响护理本科生自主学习能力,其中心理自立的效应值最大(总效应值为0.295,直接效应值0.180,间接效应值0.115);心理自立还可通过评判性思维的中介作用间接影响自主学习;教育环境5大因素均对自主学习产生直接或间接影响,其中效应值最大的是学习知觉域(总效应值为0.195,且全部为直接效应)和学术知觉域(总效应值为0.256,且全部为直接效应)。结论高等护理教育应注重培养护理本科生心理自立人格和正性评判性思维倾向,同时教育环境改善的重点应在学习知觉域和学术知觉域。