Comparison of intramural 5-fluorouracil and more conventional routes of drug administration on concentrations in gastric regional lymph nodes: a potential for trans-endoscopic adjuvant chemotherapy.

Intramural injection of 20 muCi (2-14C) 5-fluorouacil (5-FU) into the gastric submucosa of dogs and baboons was employed to evaluate the kinetics of 5-FU distribution following this route of administration and to compare these results with those following intraluminal, intravenous, and local intraarterial injections. Measurements of radioactivity taken over a six-hour period after injections demonstrated that the greatest concentration of isotope in samples of gastric wall and perigastric lymph nodes was found after administration of the drug directly into the stomach wall. Clinical application of intramural injections of 5-FU into the stomach wall under direct gastroscopic visual control, may be worthy of trial in patients with gastric cancer.     

"Horseshoe kidney" in an ectopic position. A case report

We present a case study of a horseshoe kidney, harvested from a 68-year-old patient who died suddenly from rupture of an aneurysm of the ascending aorta. The kidney was ectopically placed, its isthmus corresponding to the terminal aorta. The two kidneys were unequal in size, the right kidney being larger than the left. We discovered four renal arteries, two on the right and two on the left side, and four renal veins, one left, one middle and two on the right side. The isthmus was blood supplied by the left and the right inferior renal arteries while the venous blood was collected by the left and middle renal veins.

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Electronic Supplementary Material The french version of this article is available in the form of electronic supplementary material and can be obtained by using the Springer Link server located at .

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Rein ectopique en fer à cheval. A propos d'un cas

Résumé Un cas de rein en fer à cheval est présenté, qui provenait d'une personne âgé de 68 ans décédée subitement par rupture d'anévrisme de l'aorte ascendante. Le rein était situé en position ectopique, son isthme correspondant à l'aorte terminale. Les deux reins avaient des dimensions inégales, le rein droit étant plus grand. Il y avaient quatre artères rénales, deux droites et deux gauches et quatre veines rénales, une gauche, une moyenne et deux droites. La portion isthmique était vascularisée par les artères rénales inférieures gauche et droite, le sang veineux était collecté par les veines rénales gauche et moyenne.

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序贯疗法与10d四联疗法抗Hp疗效对比分析

目的：比较10d序贯疗法和10d四联疗法根除Hp疗效和患者依从性,进一步探讨序贯疗法的机制。方法：将经胃镜检查确诊为慢性胃炎和消化性溃疡且Hp检测（尿素酶试验）阳性的患者170例随机分为A组和B组各85例,A组采用前5d奥美拉唑＋阿莫西林、后5d奥美拉唑＋克拉霉素＋替硝唑序贯疗法;B组采用奥美拉唑＋阿莫西林＋克拉霉素＋替硝唑四联疗法,疗程10d,观察Hp根除情况和患者的依从性。结果：Hp根治率A组明显优于B组（P〈0.05）,且A组依从性优于B组。结论：在疗程和药物选择相同的情况下,序贯疗法明显优于10d四联疗法。     

含左氧氟沙星四联方案补救治疗幽门螺杆菌52伤临床分析

目的探讨含左氧氟沙星四联方案在补救治疗幽门螺杆菌中的应用价值。方法选择消化性溃疡及慢性萎缩性胃炎患者102例,分为观察组和对照组,观察组患者应用雷贝拉唑、左氧氟沙星、阿莫西林及胶体果胶铋,对照组患者应用雷贝拉唑、阿莫西林、胶体果胶铋,治疗周期为14d。结果治疗4周后,观察组中46例患者幽门螺杆菌阴性比例为88．5％。对照组中36例患者幽门螺杆菌阴性比例为72．0％,观察组患者幽门螺杆菌转阴率明显高于对照组（χ2=4．3820,P=0．0363）。两组患者不良反应发生率间差异无统计学意义（χ2=0．5725,P=0．4493）。结论含左氧氟沙星四联方案在补救治疗幽门螺杆菌中具有良好的效果。     

甘羟铝片联合四联药物治疗复发性消化性溃疡的疗效观察

目的观察甘羟铝片联合四联药物（质子泵抑制剂、枸橼酸铋钾、呋喃唑酮、阿莫西林）治疗复发性消化性溃疡的疗效。方法选取复发性消化性溃疡患者84例,随机分治疗组和对照组,分别给予甘羟铝片联合四联疗法或以四联疗法治疗,总疗程均为14d。结果疗程结束时,治疗组总有效率为97．6％,对照组总有效率为88．1％,两组疗效差异无统计学意义（P〉0．05）,但是治疗组症状完全缓解天数少于对照组（P〈0．05）。两组幽门螺杆菌转阴率和溃疡愈合率差异无统计学意义（P〉0．05）。结论以甘羟铝片联合四联疗法与以四联疗法治疗复发性消化性溃疡均安全、有效,但是以甘羟铝片联合四联疗法缓解症状更快,依从性更好,是治疗复发性消化性溃疡较好的方案。     

“四联疗法”对支气管扩张并大咯血的治疗观察

目的观察垂体后叶素+硝苯地平+止血敏+强的松(简称"四联疗法")对支气管扩张大咯血的临床治疗效果。方法94例患者随机将其分为甲组,乙组(四联疗法治疗组):甲组44例,乙组50例,甲组首次使用5U溶于20ml生理盐水后静脉缓推,以后500ml液体中加入20U维持滴注,每天总量20～40U。同时并用止血敏1g加入葡萄糖250ml稀疏释后静滴,每日2～3次。口服硝苯地平10mg每日3～4次。乙组首次使用5U垂体后叶素溶于20ml生理盐水后静脉缓推,以后500ml液体中加入20U维持滴注,每天总量20～40U。同时并用止血敏1g加入葡萄糖250ml稀疏释后静滴,每日2～3次。口服硝苯地平10mg每日3～4次,强的松,每日30mg。结果甲组有效止血44例,占95%,平均止血时间7天;乙组有效止血48例,占96%,平均止血时间5天(P<0.05)。结论四联疗法能缩短支气管扩张大咯血治疗时间。     

四联疗法对消化性溃疡的研究

目的：研究分析四联疗法治疗幽门螺杆菌感染消化性溃疡的临床治疗效果及治疗后复发情况。方法：选取笔者所在医院收治的Hp感染消化性溃疡患者120例,将其随机分为观察组和对照组,每组各60例。对照组采用奥美拉唑＋阿莫西林＋克拉霉素治疗。观察组采用奥美拉唑＋阿莫西林＋克拉霉素＋枸橼酸铋钾的四联疗法治疗。观察比较两组患者治疗后消化性溃疡愈合、Hp根除及复发率情况。结果：观察组治疗溃疡总有效率为93.33%,对照组为90.00%,差异无统计学意义（P〉0.05）;观察组的Hp根除率为93.34%,明显高于对照组的75.00%,观察组、对照组患者的复发率分别为3.33%、11.67%,两组Hp根除率、复发率比较差异均有统计学意义（P〈0.05）。结论：四联疗法治疗消化性溃疡临床疗效显著,有效率高、Hp根除率高、不良反应较少,是治疗消化性溃疡安全有效的方法之一,值得临床应用推广。     

四联疗法治疗幽门螺杆菌相关性胃溃疡60例临床疗效分析

目的:观察四联疗法治疗幽门螺杆菌相关性胃溃疡的临床治疗效果。方法:将60例幽门螺杆菌阳性胃溃疡患者随机均分为观察组和对照组各30例,观察组患者采用埃索美拉唑+克拉霉素+阿莫西林+果胶铋四联疗法进行治疗,对照组患者采用埃索美拉唑+克拉霉素+阿莫西林进行治疗。结果:观察组患者显效率和总有效率均明显高于对照组,差异有统计学意义(P<0.05)。两组患者均未出现明显不良反应。结论:埃索美拉唑、克拉霉素、阿莫西林、果胶铋四联疗法治疗幽门螺杆菌阳性胃溃疡效果优于三联疗法,值得推广。     

消化性溃疡临床治疗中四联疗法的效果观察

目的:就四联疗法对于消化性溃疡的治疗效果进行分析和讨论。方法:以192例消化性溃疡并幽门螺杆菌(HP)阳性患者作为分析对象,采取四联疗法对患者进行为期14d的治疗,并对治疗结果和不良反应情况进行统计。结果:在112例胃溃疡患者中,有96例患者治愈,12例患者好转,4例患者无效,临床治愈率为85.7%。在80例十二指肠溃疡患者中,有72例患者治愈,8例患者好转,0例患者无效,临床治愈率为90%。在不良反应方面,有4例患者出现轻微的呕吐和恶心症状,均在短时间内自行消除,未出现严重的用药不良反应。结论:本次研究所采用的四联疗法对于消化性溃疡具有疗效显著,不良反应轻微的满意效果,值得在今后的临床实践中进行推广和应用。     

A Multipurpose Four-Channel Fluid Swivel

This article describes the construction of a functional quadruple fluid swivel with low propensity to leaking and low resistance to rotation. It was obtained through the addition of a fourth channel and some modifications performed on the rotary unit of a triple channel fluid swivel recently described. Those modifications included alterations of the Touhey–Borst adapter (Becton-Dickinson), and the development of a new method of fixation of the rotary tubes to the rotary unit of the swivel using nuts and screws. With those improvements the former swivel was transformed in a still more versatile device that can be used in experimental designs requiring the use of this relatively high number of channels. It can be used, for instance, in simultaneous off-line brain microdialysis of up to four different areas or on-line brain microdialysis in two areas; in push–pull perfusions of two brain regions; in studies determining the neuropharmacokinetics and pharmacodynamics of any compound and combining continuous drug infusion through one channel, double brain microdialysis to describe the distribution characteristics of the drug into the central nervous system as well as to monitor the neurochemical modifications induced by the drug, and continuous plasma sampling to know the plasma pharmacokinetics of the drug. These and several other methods used in neuroscience research can also be combined using the swivel described here.