专栏——磁共振新技术在阿尔茨海默病诊断中的应用—— 阿尔茨海默病患者弥散张量成像研究

目的研究阿尔茨海默病（Alzheimer’s disease,AD）的弥散张量成像（DTI）改变,为AD的早期诊断提供依据。方法采用3.0T磁共振扫描仪对17例AD病人及17例对照组被试进行DTI检查。测量默认模式网络各种子点的FA值及脑白质纤维束感兴趣区的FA值。结果 AD组默认网络各脑区FA值较对照组均减低;联络系（双侧扣带束前、后部）、连合系（胼胝体膝部、体部及压部）、投射系（内囊前、后肢）的感兴趣区FA值较对照组均减低。结论阿尔茨海默病患者与正常老龄化组相比,弥散张量成像存在着特殊改变,能够为早期诊断阿尔茨海默病提供有效的功能影像学依据。     

我院心电网络系统建设与规划

本文分析了医院现有心电网络建设情况及成果,规划心电网络下一步建设方向,以提高医院的服务水平,促进医疗信息技术发展。     

医院移动护理系统的建设和应用

我院移动护理系统是在无线局域网的基础上,借助无线手持终端IM10建立的,实现了护理人员在床边维护病人的基本信息、医嘱、生命体征等数据及快速识别病人的药品等。移动护理系统的使用为患者提供更及时、准确、高效的医护服务,提高了医院运营效率。     

一种安全的医院数据上报解决方案

目的：为确保医疗数据在上报过程中的安全性,提供一种安全的医院数据上报解决方案。方法：采用基于安全隔离网闸的数据交换技术保证上报数据的安全性,同时保障医院的内部网络安全、可靠地运行。结果：基于网闸的数据上报的实现不仅可确保内网信．g-系统的安全．而且高效地实现了内外网的数据交换,为数据上报提供了一条安全便捷之路。结论：采用安全隔离网闸技术实现数据上报,可确保院内网的信息安全,为医院的信息化建设提供有力的保障。     

医院心电网络系统的建设与临床应用

目的：研究心血管专科医院内心电网络系统的建设与临床应用。方法：构建院级水平的心电网络化信息平台,在各病区配置网络心电图机,通过院内局域网及服务器与医院心电诊断中心对接,按设定的流程进行病例检查操作、上传、诊断、回传、结果打印与归档。结果：各病区终端心电图机、中央服务器、心电诊断中心通过局域网连接成一个整体,在医院心电网络化试验过程中,系统运行比较平稳,操作比较方便。结论：在医院内建设心电网络系统能明显提高临床心电检查及诊断工作的效率。     

野战医疗所医疗物资智能管理系统的研制

目的：提高战备物资的调配速度和战地使用管理的信息化水平。方法：利用射频识别和网络技术,扫描医疗物资射频识别码信息,实现医疗物资的自动识别和统计管理。结果：系统实现了医疗物资的快速出入库、战地物资发放和消耗统计智能化,缩短了库房盘点时间,提高了野战医疗所医疗的响应速度和战地物资的管理效率。结论：系统的研制完成,保证了野战医疗所的物资管理最佳备用状态和战地补给的及时性,对于提高野战医疗所的快速反应能力具有重要意义。     

Acrylamide exposure impairs blood-cerebrospinal fluid barrier function

Previous studies show that chronic acrylamide exposure leads to central and peripheral neu- ropathy. However, the underlying mechanisms remained unclear. In this study, we examined the permeability of the blood-cerebrospinal fluid barrier, and its ability to secrete transthyretin and transport leptin of rats exposed to acrylamide for 7, 14, 21 or 28 days. Transthyretin levels in cerebrospinal fluid began to decline on day 7 after acrylamide exposure. The sodium fluorescein level in cerebrospinal fluid was increased on day 14 after exposure. Evans blue concentration in cerebrospinal fluid was increased and the cerebrospinal fluid/serum leptin ratio was decreased on days 21 and 28 after exposure. In comparison, the cerebrospinal fluid/serum albumin ratio was increased on day 28 after exposure. Our findings show that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs secretory and transport functions. These changes may underlie acrylamide-induced neurotoxicity.     

Puerarin accelerates neural regeneration after sciatic nerve injury

Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin(8-(β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) were injected intraperitoneally into mouse models of sciatic nerve injury. Puerarin at the middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling, and reduced the atrophy of the triceps surae on the affected side and promoted the regeneration of nerve fibers of the damaged spinal cord at 8 weeks after injury. We conclude that puerarin exerts an ongoing role to activate growth-associated protein 43 in the corresponding segment of the spinal cord after sciatic nerve injury, thus contributing to neural regeneration after sciatic nerve injuries.     

Baicalin suppresses iron accumulation after substantia nigra injury: relationship between iron concentration and transferrin expression

Previous studies have shown that baicalin prevented iron accumulation after substantia nigra injury, reduced divalent metal transporter 1 expression, and increased ferroportin 1 expression in the substantia nigra of rotenone-induced Parkinson's disease rats. In the current study, we investigated the relationship between iron accumulation and transferrin expression in C6 cells, to explore the mechanisms of the inhibitory effect of baicalin on iron accumulation observed in Parkinson's disease rats. Iron content was detected using inductively coupled plasma-atomic emission spectroscopy. Results showed that iron content decreased 41% after blocking divalent metal transporter 1 and ferroportin 1 proteins. After treatment with ferric ammonium citrate of differing concentrations(10, 50, 100, 400 μg/mL) in C6 glioma cells, cell survival rate and ferroportin 1 expression were negatively correlated with ferric ammonium citrate concentration, but divalent metal transporter 1 expression positively correlated with ferric ammonium citrate concentration. Baicalin or deferoxamine reduced divalent metal transporter 1 expression, but increased ferroportin 1 expression in the 100 μg/mL ferric ammonium citrate-loaded C6 cells. These results indicate that baicalin down-regulated iron concentration, which positively regulated divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra.