对消炎利胆片现行质量标准中含量测定的建议

目的:建议将消炎利胆片现行质量标准中含量测定方法中的"蒸干"改为"挥干".方法:依照国药监局2000ZFB0036文中含量测定方法对蒸干部分及挥干部分进行检测.结果:发现水浴蒸干会使脱水穿心莲内酯的色谱峰峰面积积分值大大降低.结论:原含量测定方法中水浴蒸干的操作会导致实测结果含量偏低.     

HPLC法测定健胃愈疡片中芍药苷的含量

目的:改进健胃愈疡片中芍药苷的含量测定方法.方法:采用HPLC测定健胃愈疡片中芍药苷的含量.色谱柱为ODS-C18(250×4.6mm,5μm),流动相为甲醇:水(25:70),检测波长为230nm.结果:平均回收率为98.8%,RSD=1.01%.结论:本法简便、灵敏、准确,具有实用价值.     

银杏叶提取物抗鼠肾缺血再灌注损伤及对P选择素表达的影响

目的 :探讨银杏叶提取物保护大鼠肾脏缺血再灌注损伤作用与机理。方法 :SD大鼠随机分为假手术组、缺血再灌注组、银杏叶提取物组。通过HE染色观察肾组织损伤和中性粒细胞浸润 ,免疫组织化学方法观察P选择素的表达情况。结果 :与假手术组相比 ,缺血再灌注组肾小管上皮细胞呈明显的缺血性改变 ,P选择素表达明显增强 (P <0 .0 1) ,肾小球内中性粒细胞增加明显 (P <0 .0 0 1) ;银杏叶提取物组比缺血再灌注组肾小管上皮细胞缺血性改变减轻 ,P选择素表达减少 (P <0 .0 1) ,肾小球内中性粒细胞较缺血再灌注组减少 (P <0 .0 0 1)。结论 :银杏叶提取物减轻大鼠肾缺血再灌注损伤 ,减少P选择素表达及中性粒细胞浸润     

舒血宁联合复方丹参片对急性脑梗塞患者血清超敏C反应蛋白、脂蛋白的影响及其临床疗效

目的 探讨舒血宁联合复方丹参片对急性脑梗塞患者（ACI）血清超敏C反应蛋白、脂蛋白的影响及其临床疗效。方法 选取青海省人民医院2014年4月～2015年9月收治的80例ACI患者,随机分为对照组和观察组,每组40例。对照组给予舒血宁注射液静脉滴注,研究组在此基础上,再予以复方丹参片口服。检测两组相关生化指标及血液流变学的变化,NIHSS及BI评分评估治疗前后神经功能及日常生活能力,NIHSS评分比较其临床疗效。结果 与治疗前比较,两组hs-CRP、LP、PAF及LP-PLA2水平均明显降低(P＜0.05),血液流变学指标亦明显降低(均P＜0.05),NIHSS评分显著降低(P＜0.05),BI评分显著升高(P＜0.05);与对照组比较,观察组hs-CRP、LP、PAF及LP-PLA2水平均较低(均P＜0.05),血液流变学指标及NIHSS评分均较低(均P＜0.05),但BI评分较高(P＜0.05),治疗有效率较高(P＜0.05)。结论 舒血宁联合复方丹参片能有效治疗急性脑梗塞,改善血液流变学,促进神经功能的恢复及预后,且能降低hs-CRP及LP水平。     

Fulfilling the psychological and information need of the family members of critically ill patients using interactive mobile technology: A randomised controlled trial

BackgroundIntensive care nurses may have an important role in empowering families by providing psychological support and fulfilling the family's pivotal need for information.AimTo determine whether ‘education of families by tab’ about the patient’s condition was more associated with improved anxiety, stress, and depression levels than the ‘education of families by routine’.Research designA randomized control trial of 74 main family caregivers (intervention: 39; control: 35).SettingAn adult intensive care unit.Main outcome measuresDepression Anxiety Stress Scale, and Communication and Physical Comfort Scale.ResultsAlthough information need satisfaction was not significantly different between intervention and control groups, the former reported significantly better depression score on Depression Anxiety Stress Scale comparing to the control group (p < 0.01; η² = 0.09) with a medium effect size. Reduction of anxiety in the intervention group were clinically significant.ConclusionThe results suggest that use of ‘education of family by tab’ is promising for intensive care nurses to provide psychological support for family members. More studies are needed to investigate this aspect of family care for better psychological support and information need satisfaction that contributes to the evidence-based practice of intensive care nursing.     

曲安奈德配合金纳多治疗单侧急性低频下降型感音神经性聋

目的探讨耳后注射曲安奈德配合金纳多银杏叶提取物片治疗单侧急性低频下降型感音神经性聋(ALHL)临床疗效。方法选取2014-05—2016-09开封市祥符区中医院收治的78例单侧ALHL患者,通过随机数字表法分为研究组与对照组各39例。对照组采用舒血宁注射液+地塞米松注射液治疗,研究组采用曲安奈德+金纳多银杏叶提取物片治疗,2组均持续治疗10d。疗程结束后对比2组临床疗效、不良反应发生率,分析治疗前后血清免疫功能指标(IgM、IgG、CD3~+、CD4~+)水平变化。结果研究组总有效率为94.87%(37/39),高于对照组的74.36%(29/39),差异有统计学意义(P0.05);治疗前2组IgM、IgG、CD3~+、CD4~+水平比较差异无统计学意义(P0.05),治疗后研究组IgM、IgG、CD3~+、CD4~+水平高于对照组,差异有统计学意义(P0.05);研究组不良反应发生率7.69%(3/39),与对照组10.26%(4/39)比较,差异无统计学意义(P0.05)。结论耳后注射曲安奈德配合金纳多银杏叶提取物片治疗单侧ALHL效果显著,可有效提高患者听力水平,且对改善其免疫功能具有重要作用,安全性较高,值得推广。     

银杏达莫注射液对脑梗死患者IL-1β、IL-6的影响

目的观察银杏达莫注射液对急性脑梗死患者血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平的影响。方法 80例急性脑梗死患者随机分为两组,治疗组予以常规措施并加银杏达莫注射液治疗,对照组仅用常规治疗。观察治疗前后血清IL-1β、IL-6水平的变化。结果两组治疗后血清I L-1β、IL-6的浓度较治疗前有明显降低,但治疗组降低较对照组更显着(P<0.05)。结论银杏达莫注射液可显著降低急性脑梗死患者血清IL-1β、IL-6的水平而降低炎症反应,在治疗急性脑梗死中起重要作用。     

Formulation and optimization of potassium iodide tablets

The use of potassium iodide (KI) as a protective agent against accidental radioactive exposure is well established. In this study, we aimed to prepare a KI tablet formulation using a direct compression method. We utilized Design of Experiment (DoE)/mixture design to define the best formulation with predetermined physical qualities as to its dissolution, hardness, assay, disintegration, and angle of repose. Based on the results from the DoE, the formulation had the following components (%w/w): Avicel 48.70%, silicon dioxide 0.27%, stearic acid (1.00%), magnesium stearate 2.45%, and dicalcium phosphate 18.69%, in addition to potassium iodide 28.89% (130 mg/tablet). This formulation was scaled-up using two tablet presses, a single-punch press and a rotary mini tablet press. The final scaled-up formulation was subjected to a variety of quality control tests, including photo-stability testing. The results indicate that potassium iodide tablets prepared by a rotary mini tablet press had good pharmaceutical characteristics and a shelf-life of 25 days when stored at room temperature protected from light.     

温阳散瘀方联合贝前列素钠片治疗下肢动脉粥样硬化性闭塞症的临床研究

目的观察温阳散瘀方辅助贝前列素钠片治疗下肢动脉粥样硬化性闭塞症的效果。方法采用简单随机抽样方法从2016年3月至2018年4月于该院接受诊治的下肢动脉粥样硬化性闭塞症患者中选取86例纳入研究,依据随机数字表法进行分组,对照组43例患者接受贝前列素钠片治疗,研究组43例患者接受温阳散瘀方联合贝前列素钠片治疗,治疗6周后评价两组临床疗效,测定两组患者血脂水平、踝肱指数(ABI)、6min步行试验(6-MWT)、无痛行走距离、超敏C反应蛋白(hs-CRP)以及血液流变学相关指标。结果研究组临床总有效率(88.37%)明显高于对照组(69.77%),差异有统计学意义(P<0.05);治疗后两组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均明显下降(P<0.05),且组间比较差异有统计学意义(P<0.05);治疗后研究组ABI、6-MWT、无痛行走距离和hs-CRP水平均明显优于对照组(P<0.05);治疗后两组血液流变学相关指标均明显下降(P<0.05),且组间比较差异有统计学意义(P<0.05)。结论温阳散瘀方辅助贝前列素钠片应用于下肢动脉粥样硬化性闭塞症的临床治疗,在平衡血脂水平、改善血液流变学相关指标方面效果明显,可有效改善ABI、6-MWT、无痛行走距离和hs-CRP等指标,增进疗效。     

The use of Ginkgo biloba in healthy elderly

To promote health-conscious behavior in the aging society and gain insight into the sources of knowledge on which preventive strategies are based, analyzing the behavior of elderly people who are recognized as highly health conscious may be useful. We focused on the use of Ginkgo biloba, which is commonly considered to be effective in preventing cognitive decline and dementia, among elderly adults. A total of 1,672 questionnaires were distributed among geriatric participants (60–94 years) who attended university lectures at 22 universities throughout Germany. Response rate was 36.1 %. We collected data on demographic characteristics, preventive strategies (use of Ginkgo and other supplements), health-conscious behavior, sources of knowledge concerning health behavior, and factors associated with the participants’ concept of aging. The prevalence of Ginkgo use was 15.3 %. Ginkgo was assumed to be effective for cognitive enhancement and the treatment of cognitive decline by two thirds of the surveyed participants and one third believed Ginkgo to be effective for preventing dementia. Ginkgo use was significantly higher among participants using natural remedies and herbal and food supplements. The use of Ginkgo was recommended by physicians (57.3 %), chemists (16 %), and healthcare magazines (10.7 %). Food supplements were taken by 65.8 % of the sample: this percentage was significantly higher among subjects who exhibited health-conscious behavior. “Knowledge” about strategies to enhance cognition or prevent cognitive decline among the elderly do not appear to be evidence based. Thus, there is a need to establish reliable and independent sources of scientific information for healthcare professionals and the general public.