增液八珍汤治疗习惯性便秘

目的 观察增液八珍汤治疗习惯性便秘的临床疗效.方法 将100例习惯性便秘的患者随机分成治疗组和对照组,各50例.治疗组口服增液八珍汤(党参、白术、茯苓、当归等,1剂/d,早晚分服)治疗;对照组口服西沙比利(10 mg/次,3次/d,饭前口服),疗程1个月.分别检测治疗前后受试者血清中胃泌素(GAS)、P物质(SP)、生长抑素(SS)的含量.结果 治疗组治愈率58％,总有效率为98％,复发率10.3％;对照组治愈率24％,总有效率为72％,复发率33.3％.2组治愈率、总有效率比较,差异有统计学意义(P＜0.01,P＜0.05);治疗前后2组受试者血清中胃泌素(GAS)、P物质(SP)、生长抑素(SS)含量均有明显变化,治疗组变化明显优于对照组(P＜0.05).结论 增液八珍汤治疗习惯性便秘复发率低,无毒副作用,并能改善血清中GAS、SP、SS含量.     

What is the patient acceptability of real time 1:1 videoconferencing in an orthopaedics setting? A systematic review

Background

Real time 1:1 videoconferencing (VC) has the potential to play an important role in the management of orthopaedic pathologies. Despite positive reporting of telemedicine studies uptake in clinical practice remains low. Acceptability to patients is an important element of system take-up in telemedicine and a focus towards qualitative methodology may explore the underlying reasons behind its acceptability. In this paper we have systematically reviewed qualitative studies that include evidence about patient responses to VC services in an orthopaedic setting.

Changing Physical Activity Behavior in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis

Objectives

To (1) systematically review the literature on behavioral interventions for people with multiple sclerosis (MS) that aim to change physical activity (PA) behavior; and (2) explore whether these interventions are clinically effective in improving PA, are theory based, and use established behavior change techniques (BCTs).

Translational Mobilisation Theory: A new paradigm for understanding the organisational elements of nursing work

Translational Mobilisation Theory (TMT) is a generic sociological theory that explains how emergent projects of collective action are progressed in complex organisational contexts. Grounded in a substantial programme of research on healthcare work, it has value for understanding the organisational component of the nursing role for educational, practice and research purposes. This paper introduces Translational Mobilisation Theory, outlines its core components, and considers its application to nursing using ethnographic research on the organising work of nurses as an empirical reference. Organising work is a neglected element of the nursing function and lacks theoretical foundations. As the complexity and intensity of healthcare continues to accelerate this is an important gap in existing frameworks of understanding.     

多元智力理论视阈下的医学信息学本硕博连读培养模式

［］本硕博连读研究生培养模式旨在培养具有原创精神和能力的研究型人才。本文从多元智力理论出发,从理论层面对本硕博连读培养模式进行阐述;结合研究生教育改革实践,从选拔标准、培养模式、过程管理、质量监控、分流淘汰机制、论文答辩以及学术成果要求等几个方面对医学信息学本硕博连读培养中的关键环节进行了分析。     

TREATMENT OF HAIRY CELL LEUKEMIA WITH INCREASING DOSES OF RECOMBINANT ALPHA A INTERFERON

:Since July 1984, eight patients with advanced hairy cell leukemia have received treatment with recombinant alpha A interferon. At commencement of interferon, seven patients had progressive cytopenia, and one was in leukemic phase (>20times10⁹/L circulating hairy cells). All patients had had previous splenectomy. Interferon was administered subcutaneously. The initial dose was 3times10⁶ U/day, continued until peripheral counts stabilised. Subsequently, patients received 6times10⁶ U/day, 9times10⁶ U/day, and finally 12 times 10⁶ U/day. The dose increases proceeded every 8–12 weeks, as tolerated. Seven patients had an objective response. There were four complete remissions, two partial remissions, and one minor response. Complete remission was documented only in patients on at least 6 times 10⁶ U/day for 12 weeks. The median time to complete remission was 40 weeks (range 35–53). Normalisation of peripheral blood counts preceded histologic marrow improvement. The median times for response (platelets ≤ 100 times 10⁹L, hemaglobin > 12 gm/dL, neutrophils < 1.5 times 10⁹/L), were six to eight and 17 weeks, respectively. Toxicity included myelosuppression during the first four weeks of therapy. With increasing doses of interferon, myelosuppression did not recur. A transient, mild, flu-like syndrome affected all patients. Two patients developed asymptomatic transaminitis at doses >6 times 10⁶ U/day. This resolved with dose reduction. In one case impotence was reported during the first four weeks of each interferon level. One patient discontinued after two weeks due to an exacerbation of systemic vasculitis. The median duration of treatment for the seven responding patients is 78 weeks (range 30–156). All remain on interferon without disease progression. This report confirms a high remission rate, which may reflect a dose-response phenomenon for long-term treatment with alpha interferon in hairy cell leukemia. (Aust NZ J Med 1988; 18: 557–562).     

嗜人按蚊迁飞可能性的研究Ⅰ "同期突增"和"同期突发"现象的初步观察

目的观察嗜人按蚊是否存在"同期突增"和"同期突发"现象,以期探讨嗜人按蚊存在迁飞特性的可能性. 方法在浅山区约2 km2范围内,选择位于不同山沟内相互隔离的3个自然村,采用室内全夜灯光诱捕法,观察嗜人按蚊、中华按蚊和三带喙库蚊是否存在"突增突发"现象. 结果嗜人按蚊和三带喙库蚊均存在"突增突发"现象;中华按蚊未出现这种现象. 结论嗜人按蚊存在迁飞特性的可能性.