头皮发际区微针法治疗糖尿病周围神经病变的临床研究

目的观察头皮发际区微针法治疗糖尿病周围神经病变的临床疗效。方法将60例糖尿病周围神经病变患者随机分为2组。治疗组30例用头皮发际区微针法,每日1次。对照组30例用甲钴胺0.5mg,每日早晚各1次口服。2组均60d为1个疗程,1个疗程后统计疗效,并检测血浆内皮素（ET）和一氧化氮（NO）含量。结果治疗组总有效率86.67%,对照组总有效率90.00%,2组比较差异无统计学意义（P〉0.05）。2组治疗前后血浆ET和NO含量比较差异均有统计学意义（P〈0.05） 2组治疗前后血浆ET和NO含量差值比较差异无统计学意义（P〉0.05）。结论头皮发际区微针法对于糖尿病周围神经病变患者具有确切疗效,其治疗机制与调节ET和NO平衡失调,改善血液循环状态相关。     

急性有机磷中毒动物血糖及胆碱酯酶活力的动态监测研究

目的：动态监测急性有机磷中毒动物在急性有机磷中毒及解救过程中血浆的乙酰胆碱酯酶活性和血糖值变化，依据此两项指标与中毒程度的相关性，为临床救治提供新的方法以及实验依据。方法：通过耳缘静脉注射5％敌百虫溶液（2mL／kg）先后对12只家兔建立急性有机磷中毒模型，分别在模型动物处于正常、轻、中、重度中毒和救治的时段采血，动态监测血浆乙酰胆碱酯酶活力和血糖两项指标变化。结果：在急性有机磷中毒过程中，血糖值升高与乙酰胆碱酯酶活力降低相比较，血糖浓度动态变化与中毒轻重程度相关性较好，并能体现机体对中毒的应激程度。结论：血糖浓度能较好地反映有机磷中毒深度以及机体应激程度，可作为临床评估危重程度的动态性快速诊断指标。     

壮医皮肤针治疗丹毒局部皮肤硬肿疗效观察

目的观察壮医皮肤针治疗丹毒局部皮肤硬肿的疗效。方法将150例丹毒局部皮肤硬肿患者分为两组，针刺组110例，用壮医皮肤针、金黄散配合治疗：对照组40例，用金黄散治疗，观察两组有效率。结果针刺组总有效率为97．3％，对照组总有效率为75．0％，针刺组总有效率高于对照组，两组比较差异具有统计学意义（P〈0．01）。结论壮医皮肤针配合金黄散治疗丹毒局部皮肤硬肿能提高其总有效率。     

改良《颈性眩晕症状与功能评估量表》在椎动脉型颈椎病中医临床中的应用及评价

目的探讨改良《颈性眩晕症状与功能评估量表》在椎动脉型颈椎病(CSA)的中医临床中的应用可行性。方法151例CSA患者随机分为针灸推拿治疗组和单针灸对照组,治疗前后采用改良《颈性眩晕症状与功能评估量表》进行量化评估,并对该量表在本次中医临床中的效度及信度进行初步检验。结果治疗组治疗后症状与功能评分比治疗前有显著提高(p<0.01),治疗组改善指数明显高于对照组(p<0.05)。经检验,该量表也有可以接受的准则效度(r在0.8-0.9之间,p<0.01)和再测信度(r在0.6-0.9之间,p<0.01)。结论针灸推拿结合治疗CSA具有确切的临床疗效,能明显改善患者症状、颈椎功能和生活质量。改良《颈性眩晕症状与功能评估量表》在CSA中医临床中具有可信性、有效性。     

电针加火罐治疗面神经麻痹的研究

目的　观察电针加火罐治疗面神经麻痹的效果。方法　选择面神经麻痹患者 4 0例 ,随机分为治疗组 2 0例 ,予以电针加火罐治疗 ;对照组 2 0例口服祛风药或维生素B族药物治疗 ,并进行疗效比较。结果　经过 4周治疗 ,治疗组总有效率为 95 % ,对照组总有效率为 75 % ,两组相比有非常显著性差异。结论　电针加火罐治疗面神经麻痹疗效显著 ,且无任何副作用     

动力髋螺钉治疗股骨转子间骨折

目的 评价动力髋螺钉(DHS)治疗股骨转子间骨折的临床效果。方法 1996年3月～2002年3月用DHS共治疗患者29例．骨折按Evans分型，本组Evans ⅠA2例，Evans ⅠB 10例，Evans ⅡA 3例，Evanslib12例，Evans Ⅲ2例．结果 29例患者均获随访，随访12～48个月，平均26个月，根据Harris髋关节评分：优16例，良9例，中3例，差1例。结论 如能及时手术良好复位，DHS是治疗股骨转子间骨折的较好选择。     

头皮针对脑缺血模型大鼠血浆内皮素-1的影响

目的 :研究头皮针对脑缺血模型大鼠内皮素 - 1 ( ET- 1 )的影响 ,并与电针组比较。方法 :Wistar大鼠 5 0只 ,随机分正常、假手术、模型、电针、头皮针五组 ,每组 1 0只 ,后四组均于造模后 72小时、1 0天、1 5天取血测 ET- 1 ,并与手术后 6小时测定值进行比较 ;前三组不治疗 ,后两组造模后分别用电针与头皮针治疗。观察治疗前后 ET- 1测定值。结果 :神经功能评分 ,术后 1 0天与 1 5天 ,治疗组与模型组有显著性差异 ( P<0 .0 5～ 0 .0 1 ) ,电针组与头皮针组 ET- 1测定值无明显差异。对ET- 1的影响 ,术后 72小时及 1 0天时 ,治疗组 ET- 1明显低于模型组 ( P<0 .0 5 ) ,头皮针组明显低于电针组 ( P<0 .0 5 )。结论 :头皮针可在脑缺血早期就明显降低血浆 ET- 1含量 ,这可能是头皮针减轻脑缺血损伤并促进肢体功能恢复的机制之一。     

Complex Genetic Disease: Can Genetic Strategies in Alzheimer's Disease and New Genetic Mechanisms Be Applied to Epilepsy?

Summary: Strategies used in molecular genetics have changed modern neurology. The gene or genes responsible for several major neurologic diseases have now been identified using "reverse" or positional genetics. Unexpected new genetic mechanisms have been discovered in human neurologic diseases, including (a) identical mutations of the prion protein gene in Creutzfeldt-Jakob disease and fatal familial insomnia with the phenotypic expression directed by an accompanying polymorphism; (b) stable duplications of chromosome 17 in Charcot-Marie-Tooth disease (type 1 A) that involve many genes, only one of which appears to cause neuropathy; and (c) highly variable, dynamic mutations in myotonic dystrophy, fragile X syndrome, and Kennedy's syndrome that modulate variable expressivity in multiple tissues. There is growing recognition that neurologic diseases are often complex genetic diseases with multifactorial rather than simple modes of inheritance. For example, genetic association/linkage strategies have interacted with biochemistry and immunopathology studies to produce new insights into the disease mechanism of late-onset Alzheimer's disease. The role of apolipoprotein E in late-onset Alzheimer's disease is an example of how new analytical techniques of genetic disease can be applied to dissect multiple genes. Similar research strategies are suggested for the study of epilepsy as a complex disease.     

Initial evaluation of123|-5-|-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects

The mapping of 5-HT₂ receptors in the brain using functional imaging techniques has been limited by a relative lack of selective radioligands. Iodine-123 labelled 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (¹²³I-5-I-R91150 or¹²³I-R93274) is a new ligand for single-photon emission tomography (SPET), with high affinity and selectivity for 5-HT_2A receptors. This study reports on preliminary¹²³I-5-I-R91150 SPET, wholebody and blood distribution findings in five healthy human volunteers. Maximal brain uptake was approximately 2% of total body counts at 180 min post injection (p.i.). Dynamic SPET sequences were acquired with the brain-dedicated, single-slice multi-detector system SEM-810 over 200 min p.i. Early peak uptake (at 5 min p.i.) was seen in the cerebellum, a region free from 5HT_2A receptors. In contrast, radioligand binding in the frontal cortex increased steadily over time, up to a peak at approximately 100–120 min p.i. Frontal cortex-cerebellum activity ratios reached values of 1.4, and remained stable from approximately 100 min p.i. onwards. Multi-slice SPET sequences showed a pattern of regional variation of binding compatible with the autoradiographic data on the distribution of 5-HT_2A receptors in (cerebral cortex>striatum>cerebellum). These findings suggest that¹²³I-5-I-R91150 may be used for the imaging of 5-HT_2A receptors in the living human brain with SPET.     

Dynamic response of the occipito-atlanto-axial (C0-C1-C2) complex in right axial rotation.

The torque-angular deformation in right axial rotation until failure of the ligamentous occipito-atlanto-axial complex subjected to variable loading rate (dynamic) axial torque was characterized using a biaxial MTS system. A special fixture and gear box that permitted right axial rotation of the specimen until failure without imposing any additional constraints were used to obtain the data. The specimens were divided into three groups and tested until failure at three different dynamic loading rates: 50, 100, and 400 degrees/s. A previous study by the authors provided data for quasi-static (4 degrees/s) loading conditions. The torque versus rotation curves can be divided into two straight regions and two transition zones. The plots clearly indicated that at loading rates higher than 4 degrees/s, the specimens became stiffer in the region of steadily increasing resistance prior to failure. The increase in stiffness was maximum at 100 degrees/s. The stiffness decreased somewhat at 400 degrees/s in comparison with 100 degrees/s, but this decrease was not significant. The resulting torque-right axial rotation curves were also examined to estimate the magnitude of maximum resistance (torque) and the corresponding angular rotation value. The average maximum resistance torque increased from 13.6 Nm at 4 degrees/s to 27.8 Nm at 100 degrees/s. The corresponding right angular rotation data (65-78 degrees), however, did not show any significant variation with loading rate. Posttest dissection of the specimens indicated that the type of injury observed was related to the rate of axial loading imposed on a specimen during testing.(ABSTRACT TRUNCATED AT 250 WORDS)