针灸治疗子宫内膜异位症42例疗效观察

目的观察针灸治疗子宫内膜异位症的临床疗效。方法回顾性分析2010年7月～2011年7月本院妇科收治的42例子宫内膜异位症患者治疗过程,42例患者均给予针法和灸法结合治疗。结果显效29例,好转10例,无效3例,总有效率为92.86%,临床疗效满意。结论针法配合灸法治疗子宫内膜异位症临床疗效显著,值得推广。     

首发精神分裂症综合治疗临床研究

目的比较利培酮片与利培酮联合心理社会康复治疗方法治疗首发精神分裂症的疗效和安全性。方法按照患者入院顺序,把60例患者按照单双号随机分成两组,分别采用利培酮片与利培酮联合心理社会康复治疗方法进行治疗,疗程为6个月,通过PANSS、TESS、SDSS、ADL量表评价来比较两组的疗效和安全性。结果在PANSS方面,利培酮组和综合治疗组在治疗第3个月末PANSS阳性症状总分、PANSS总分均比第1个月末低;在治疗第6个月末,综合治疗组PANSS总分明显低于利培酮组(P<0.01)。在TESS方面,两组在治疗第6个月末嗜睡、肌强直、心电图改变、肝功能异常、视力模糊等不良反应比较均差异(P<0.05);在生活质量方面,利培酮组治疗第6个月末的生理职能、生理功能和一般健康状况分值显著高于治疗第1个月末,而综合治疗组治疗第6个月末所有维度分值均显著高于第1个月末(P<0.01)。结论利培酮片与利培酮联合心理社会康复治疗方法均能较有效地治疗首发精神分裂症,但若辅助心理社会康复治疗,其疗效则更显著些,安全性也更高,能较明显地提升患者的社会功能和生活质量。     

中医疗法治疗胃溃疡的临床效果观察

目的：对中医治疗胃溃疡的临床效果进行观察分析与探索。方法：选取70例患胃溃疡的患者作为研究对象，随机均分为研究组和参照组两组。研究组使用中医疗法进行治疗，参照组使用西医疗法进行治疗，最后比较这两种治疗方法的治愈效果。结果：经过对研究组和参照组治疗效果情况的对比得出，研究组总的治疗效果及愈后复发的可能性比参照组的都要好很多，两组的差异明显有统计学的意义（P〈0.05）。结论：中医疗法治疗胃溃疡的治疗效果较令人满意，并且有助于降低愈后复发的可能性，很大程度上改善了胃溃疡患者的生活质量，在临床治疗上是十分可取的治疗办法。     

Complementarity of Mental Observables

The aim of this note is to complete the discussion on the possibility of creation of quantum‐like (QL) representation for the question order effect which was presented by Wang and Busemeyer (2013). We analyze the role of a fundamental feature of mental operators (given, e.g., by questions), namely, their complementarity.     

食管癌术后早期肠内营养的临床应用

目的 探讨食管癌术后早期肠内营养的临床疗效.方法 将本院2009年9月～2012年9月住院的食管癌患者98例随机分早期肠内营养组（EEN）和传统肠内营养组（TEN）,每组49例,所有患者均于术后第1、10天测定血红蛋白（Hb）、清蛋白（ALB）、总蛋白（TP）、淋巴细胞计数（TLC）、血清转铁蛋白（TF）水平,观察患者胃肠道功能恢复情况以及各种不良反应.结果 与术前比较,治疗后1d及10 d两组患者Hb、TLC、ALB及TP均不同程度升高,前后差异有统计学意义（P＜0.05）;与TEN组比较,术后10 d EEN组患者Hb、TLC、ALB及TP均显著升高,两组差异有统计学意义（P＜0.05）.EEN组排气时间比TEN组短,差异有统计学意义（t=1 1.057,P＜0.05）;EEN组发生轻度腹胀患者6例,轻度腹泻8例,TEN组患者出现腹胀2例,轻度腹泻3例,两组差异有统计学意义（X2=9.105,P＜0.05）.结论 早期行肠内营养能改变食管癌术后患者的机体营养状态,维护和促进胃肠道功能.     

A comprehensive review of intake estimates of di-isononyl phthalate (DINP) based on indirect exposure models and urinary biomonitoring data

Di-isononyl phthalate (DINP) is a high molecular weight general purpose plasticizer used principally in the manufacture of flexible polyvinyl chloride (PVC) articles. DINP metabolites can be measured in biological media such as blood and urine. However, measurement of a substance in the blood or urine does not by itself mean that the chemical causes or is associated with adverse health outcomes. This is particularly pertinent given the advances in modern analytical techniques whereby ever diminishing trace amounts of substances can be detected. Therefore, it is a scientific necessity that risk assessors understand the relationship of biomonitoring data to estimation of exposure so that appropriate comparisons can be made to the no observed adverse effects levels (NOAELs) or other points of departure from toxicological studies in animals. In this paper, estimates of daily DINP intake are calculated for various population segments based on urinary biomonitoring data and are compared to estimates of exposure based on indirect methods and to health-based exposure guidance values. In general, intake estimates converge on a mean of 1–2 μg/kg/day regardless of source of exposure or population cluster; a value 2-orders of magnitude lower than health-based exposure guidance values, ranging from 120 to 290 μg/kg/day, which have been established by regulatory authorities and other authoritative bodies as representing acceptable levels.     

七氟烷在小儿扁桃体腺样体摘除术中的应用分析

目的:研究分析七氟烷在小儿扁桃体腺样体摘除术中的应用效果。方法:选取我院在2011年12月~2012年11月收治74例小儿扁桃体腺样体摘除术患者的临床资料进行研究分析,并按患者住院尾号分为治疗组(37例)和对照组(37例),对比两组患者的治疗效果。结果:对比两组患者麻醉效果,治疗组患者诱导、拔管及苏醒等时间均显著短于对照组患者的,且有统计学意义(P<0.05);对比两组患者麻醉过程中出现不良反应发生率,治疗组患者麻醉过程中出现不良反应发生率为16.26%,对照组患者麻醉过程中出现不良反应发生率为46.01%,治疗组患者显著低于对照组患者,且有统计学意义(P<0.05)。结论:七氟烷在小儿扁桃体腺样体摘除术中具有显著效果,且安全性较高,值得推广应用。     

Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution

Thiamine pyrophosphate (TPP)-sensitive mRNA domains are the most prevalent riboswitches known. Despite intensive investigation, the complex ligand recognition and concomitant folding processes in the TPP riboswitch that culminate in the regulation of gene expression remain elusive. Here, we used single-molecule fluorescence resonance energy transfer imaging to probe the folding landscape of the TPP aptamer domain in the absence and presence of magnesium and TPP. To do so, distinct labeling patterns were used to sense the dynamics of the switch helix (P1) and the two sensor arms (P2/P3 and P4/P5) of the aptamer domain. The latter structural elements make interdomain tertiary contacts (L5/P3) that span a region immediately adjacent to the ligand-binding site. In each instance, conformational dynamics of the TPP riboswitch were influenced by ligand binding. The P1 switch helix, formed by the 5′ and 3′ ends of the aptamer domain, adopts a predominantly folded structure in the presence of Mg²⁺ alone. However, even at saturating concentrations of Mg²⁺ and TPP, the P1 helix, as well as distal regions surrounding the TPP-binding site, exhibit an unexpected degree of residual dynamics and disperse kinetic behaviors. Such plasticity results in a persistent exchange of the P3/P5 forearms between open and closed configurations that is likely to facilitate entry and exit of the TPP ligand. Correspondingly, we posit that such features of the TPP aptamer domain contribute directly to the mechanism of riboswitch-mediated translational regulation.