幽门螺杆菌感染与一氧化氮关系研究进展

自从1983年MARSHALL和WARREN成功分离出幽门螺杆菌（helicobacter pylori，Hp）后，越来越多学者经过大量研究发现Hp是慢性胃炎、消化性溃疡的主要致病因素，与胃癌的发生亦有密切的关系。一氧化氮（NO）是左旋精氨酸在NO合酶（NOS）催化作用下生成的，NOS分为两型：原生型（cNOS）和诱生型（iNOS）。适当NO含量对调节胃动力和胃黏膜血流、维持胃黏膜的防御机制起着重要作用。NO含量的增多可能既是机体防御Hp入侵的重要手段，也是Hp引起炎症、溃疡乃至癌变的重要因素。本文拟就近几年慢性胃炎、消化性溃疡、胃癌Hp感染与NO的关系作一综述。     

多层螺旋CT灌注成像在颅脑系统疾病中的应用研究

随着多层螺旋CT的推广使用,使以脑血流动力学研究为目的的多层螺旋CT脑灌注成像(MSCT perfusion imaging)逐渐变为现实,为综合应用CT扫描技术提供了条件,为临床提供了一种全新的、极具潜力的、适用面广的影像检查新技术。一、CT脑灌注成像理论基础1.脑灌注成像理论的形成:在198     

创伤失血性休克的麻醉处理

目的：探讨创伤性失血性休克患者的麻醉处理及抗体克措施。方法：总结5年来这类手术麻醉病人共84倒，术前了解休克分类情况，选择合适的麻醉方法、药物、监测、调控措施和液体复苏。结果：84例休克中I、Ⅱ级46例，Ⅲ级34例。Ⅳ级4例。持硬麻45例，仝麻36例。神经阻滞2例，局麻1例。84例复苏成功，2例死亡，成功率97．6％。结论：创伤失血性休克，早期快速足量扩容是关键，选择合适的麻醉方法和药物非常重要。     

正常婴儿肺动脉血流特征及解剖学原理分析

目的 应用超声多普勒技术测量正常婴儿肺动脉主干及左右肺动脉血流速度,并初步探讨其可能的机理.方法 使用GE Vivid7超声诊断仪检查60例正常新生儿,分别检测1周、1个月、6个月及1年时主动脉内径AOD;肺动脉主干内径MPA及血流速度Pv,左、右肺动脉内径LPA、RPA及血流速度LPv、RPv,并计算LPA RPA/AO.结果 1周时左、右肺动脉速度高于肺动脉主干速度,且以右肺动脉明显,1周后左、右肺动脉血流速度逐渐减慢,1年后均基本低于肺动脉主干内血流速度,肺动脉主干血流速度及LPA RPA/AO比例在1周、1个月、6个月及1年组差异无统计学意义.结论 正常新生儿左、右肺动脉血流速度较高,随生长、发育肺动脉血流速度逐渐降低直至正常.     

蝮蛇抗栓酶治疗类风湿关节炎153例

目的：探讨蝮蛇抗栓酶治疗类风湿关节炎的疗效。方法：类风湿关节炎病人１５３例（男性４３例，女性１１０例，年龄５１±ｓ８ａ，病程５．２±２．０ａ）采用蝮蛇抗栓酶１．０Ｕ溶于０．９％氯化钠注射液２５０ｍＬ中静脉滴注ｑｄ，３ｗｋ为一个疗程，结果，经２例疗程治疗，近期控制３７例（２４．２％），显效４３例（２８．１％）有效６６例（４３．１％）无效７例（４．６％），总有效率９５．４％，在改善晨僵，消肿止痛及关节     

61例流行性出血热患者临床各期血液流变学观察

通过血液流变学的检测,观察61例流行性出血热患者临床各期的改变。发现出血热患者临床各期,全血粘度的均数都高于正常对照的上限值。五期中少尿期升高不明显,发热期和多尿期明显升高。红细胞聚集指数各期均有显著性升高,提示出血热整个病程是DIC的形成过程。通过动态观察临床各期血液流变学的检测可及时正确地指导临床工作。     

正常新生儿,婴儿血液动力流变学检测

血液动力流变学是机体的重要生理机能,其变化是观察人体生理、病理机能一项重要指标。正常儿童血液动力流变学测值国内报告甚少,婴儿及新生儿测值尚未见报道,我们对100例新生儿、48例1岁内婴儿进行了血液动力流变学24项参数检测。     

不同液体术前急性高容量血液稀释对深静脉血栓病人血液流变学的影响

Objective To investigate the effects of acute hypervolemic hemodilution (AHH) with different fluids on blood rheology in patients with deep vein (femoral and iliac) thrombosis. Methods Thirty ASA I or II patients aged 40-64 yr who had developed deep vein thrombosis in 48 h and were scheduled for embolectomy were randomly divided into 3 groups ( n = 10 each) ; group I normal saline (NS) ; group II 6 % HES 200/0.5 ( HES) ; group IE gelofusine (GEL). AHH was performed with normal saline, 6% HES or gelofusine infusion at 20 ml·kg-1 ·h-1 for 40 min. MAP, HR and SpO2 were monitored. Blood loss, volume of blood transfusion and fluid infused and urine output during operation were recorded. Anesthesia was induced with fentanyl 3-5 fig/kg, etomidate 0.15-0.30 mg/kg, propofol 1-2 mg/kg and succinylcholine 1-2 mg/kg and maintained with 2% isoflurane and propofol infusion at 5-8 mg·kg-1·h-1 and intermittent iv boluses of vecuronium. The patients were mechanically ventilated (VT 8 ml/kg, RR 12 bpm). PaO2 and PaCO2 were maintained within normal range. Venous blood samples were obtained before and after AHH for measurement of hematocrit (Hct), whole blood viscocity (WBV) at low or high shear rates, plasma viscosity, RBC aggregation and RBC deformation. RBC aggregation index and RBC deformation index were calculated. Results MAP and HR were stable in all patients. The amount of blood transfusion and fluid infused was significantly less in group HES and GEL than in group NS. The WBV at low or high shear rates in group HES and GEL, Hct in all 3 groups and RBC aggregation index in group HES were significantly decreased after AHH, but the RBC deformation index was significantly increased in group HES. Conclusion Colloid is better than crystalloid and HES is better than gelofusine in improving intraoperative hypercoagulability and sluggish blood flow.