全文获取类型
| 收费全文 | 5806篇 |
| 免费 | 366篇 |
| 国内免费 | 15篇 |
专业分类
| 耳鼻咽喉 | 195篇 |
| 儿科学 | 129篇 |
| 妇产科学 | 93篇 |
| 基础医学 | 340篇 |
| 口腔科学 | 132篇 |
| 临床医学 | 468篇 |
| 内科学 | 1082篇 |
| 皮肤病学 | 82篇 |
| 神经病学 | 331篇 |
| 特种医学 | 48篇 |
| 外科学 | 960篇 |
| 综合类 | 335篇 |
| 预防医学 | 525篇 |
| 眼科学 | 46篇 |
| 药学 | 154篇 |
| 中国医学 | 957篇 |
| 肿瘤学 | 310篇 |
出版年
| 2024年 | 10篇 |
| 2023年 | 97篇 |
| 2022年 | 74篇 |
| 2021年 | 257篇 |
| 2020年 | 128篇 |
| 2019年 | 761篇 |
| 2018年 | 633篇 |
| 2017年 | 389篇 |
| 2016年 | 94篇 |
| 2015年 | 84篇 |
| 2014年 | 106篇 |
| 2013年 | 156篇 |
| 2012年 | 132篇 |
| 2011年 | 108篇 |
| 2010年 | 97篇 |
| 2009年 | 104篇 |
| 2008年 | 142篇 |
| 2007年 | 123篇 |
| 2006年 | 152篇 |
| 2005年 | 150篇 |
| 2004年 | 201篇 |
| 2003年 | 168篇 |
| 2002年 | 145篇 |
| 2001年 | 66篇 |
| 2000年 | 59篇 |
| 1999年 | 58篇 |
| 1998年 | 72篇 |
| 1997年 | 50篇 |
| 1996年 | 42篇 |
| 1995年 | 33篇 |
| 1994年 | 47篇 |
| 1993年 | 51篇 |
| 1992年 | 36篇 |
| 1991年 | 20篇 |
| 1990年 | 15篇 |
| 1989年 | 10篇 |
| 1988年 | 5篇 |
| 1985年 | 154篇 |
| 1984年 | 182篇 |
| 1983年 | 137篇 |
| 1982年 | 152篇 |
| 1981年 | 129篇 |
| 1980年 | 114篇 |
| 1979年 | 95篇 |
| 1978年 | 86篇 |
| 1977年 | 70篇 |
| 1976年 | 68篇 |
| 1975年 | 47篇 |
| 1974年 | 39篇 |
| 1973年 | 31篇 |
排序方式： 共有6187条查询结果，搜索用时 15 毫秒
991.
992.
993.
994.
995.
996.
997.
Persistent hyperparathyroidism after kidney transplantation is related to graft function, but pre-transplantation risk factors of persistent hyperparathyroidism have not been evaluated in detail. We enrolled 86 patients who had undergone kidney transplantation between 2008 and 2014. Nine patients showed persistent hyperparathyroidism characterized by the following: 1) serum parathyroid hormone levels >65 pg/mL and serum calcium levels >10.5 mg/dL at 1 year after kidney transplantation; 2) parathyroidectomy after kidney transplantation; and 3) reintroduction of cinacalcet after kidney transplantation. Compared with other patients, these 9 patients had significantly longer duration of dialysis therapy (186 ± 74 mo vs 57 ± 78 mo) and more frequent treatment with cinacalcet during dialysis (89% vs 12%). Multivariate analysis showed that dialysis vintage, calcium phosphate products, and cinacalcet use before kidney transplantation were independent risk factors of persistent hyperparathyroidism after kidney transplantation. A receiver operating characteristic curve showed 72 months as the cutoff value of dialysis vintage and 55 as the cutoff value of calcium phosphate products. In conclusion, dialysis vintage >6 years, calcium phosphate products >55 (mg/dL)2, and cinacalcet use before kidney transplantation are strong predictors of persistent hyperparathyroidism. High-risk patients should be evaluated for parathyroid enlargement, and parathyroidectomy must be considered before kidney transplantation. 相似文献
998.
T. Mitsui K. Morita D. Iwami T. Kitta Y. Kanno K. Moriya M. Takeda N. Shinohara 《Transplantation proceedings》2017,49(1):65-67
Background
We investigated whether the age of donor kidneys influences the incidence of nocturnal polyuria in patients with successful renal transplantation (RTX).Methods
Eighty-five patients (45 men and 40 women) undergoing RTX (median age, 47 years) were included in this study. Twenty-four-hour bladder diaries were kept for 3 days, and nocturnal polyuria was defined as a nocturnal polyuria index (nocturnal urine volume/24-hour urine volume) of >0.33. Risk factors for nocturnal polyuria were analyzed in patients with RTX by means of the Mann-Whitney U test, χ2 test, and a logistic regression analysis.Results
End-stage renal disease (ESRD) developed from diabetes mellitus in 16 patients (19%). Sixty-five patients (76%) received pre-transplant dialysis, with a median duration of 5 years. The median serum creatinine level and body mass index at the most recent visit were 1.2 mg/dL and 21.2 kg/m2, respectively. On the basis of the 24-hour bladder diaries, nocturnal polyuria was identified in 48 patients (56%). A logistic regression analysis revealed that diabetes mellitus as the original disease for ESRD was the only risk factor for nocturnal polyuria (odds ratio, 8.95; 95% confidence interval, 2.01–65.3; P = .0028). The age of donor kidneys at examination did not affect the incidence of nocturnal polyuria (P = .9402).Conclusions
Nocturnal polyuria was not uncommon in patients with successful RTX. Diabetes mellitus as the original disease for ESRD was the only risk factor for nocturnal polyuria, whereas the age of donor kidneys at examination did not affect the incidence of nocturnal polyuria. Thus, nocturnal polyuria is caused by recipient factors but not donor factors. 相似文献999.
D. Nitta K. Kinugawa T. Imamura J. Iino M. Endo E. Amiya M. Hatano O. Kinoshita K. Nawata M. Ono I. Komuro 《Transplantation proceedings》2017,49(1):125-129
Background
Although many risk factors are reported about graft rejection after heart transplantation (HTx), the effect of HLA mismatch (MM) still remains unknown, especially in the Japanese population. The aim of the present study was to investigate the influence of HLA MM on graft rejection among HTx recipients in Japan.Methods
We retrospectively investigated the association of the number of HLA MM including class I (A, B) and class II (DR) (for each locus MM: 0 to 2, total MM: 0 to 6) and the incidence of moderate to severe acute cellular rejection (ACR) confirmed by endomyocardial biopsy (International Society for Heart and Lung Transplantation grade ≥ 3A/2R) within 1 year after HTx.Results
Between 2007 and 2014, we had 49 HTx cases in our institute. After excluding those with insufficient data and positive donor-specific antigen, finally 35 patients were enrolled. Moderate to severe ACR was observed in 16 (45.7%) patients. The number of HLA-DR MM was significantly associated with the development of ACR (ACR+: 1.50 ± 0.63, ACR?: 1.11 ± 0.46, P = .029). From univariate analysis, DR MM = 2 was the only independent risk factor for ACR episodes (P = .017). The frequency of ACR within 1 year was significantly higher in those with DR MM = 2 (DR MM = 0 to 1: 0.3 ± 0.47, DR MM = 2: 1.17 ± 1.34 times, P = .007).Conclusions
The number of HLA-DR MMs was associated with the development and recurrence of ACR episodes among HTx recipients within 1 year after transplantation in Japanese population. 相似文献1000.
N. Nakamura T. Miyazaki H. Matsuzaki R. Furuya S. Miyajima S. Irie H. Matsuoka M. Tanaka 《Transplantation proceedings》2017,49(1):32-36