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101.
目的:探讨苦碟子注射液治疗突发性聋的效果。方法:随机将120例患者分为两组,治疗组60例,予以苦碟子注射液治疗;对照组60例,予以低分子右旋糖酐联合复方丹参注射液治疗。结果:治疗组治疗耳聋、耳鸣总有效率分别为88.33%、82.86%,对照组分别为68.33%、62.50%,治疗组耳聋、耳鸣总有效率均明显高于对照组(P<0.05)。结论:苦碟子注射液治疗突发性聋疗效好且安全可靠,无明显不良反应。 相似文献
102.
Manish Gautam Santanu Saha Sarang Bani A. Kaul Sanjay Mishra Dada Patil N.K. Satti K.A. Suri Sunil Gairola K. Suresh Suresh Jadhav G.N. Qazi Bhushan Patwardhan 《Journal of ethnopharmacology》2009
Ethnopharmacological relevance
Roots of Asparagus racemosus Willd (Shatavari in vernacular) are widely used in Ayurveda as Rasayana for immunostimulation, galactogogue as also in treatment of conditions like ulcers and cancer. Various studies have indicated immunomodulatory properties of Shatavari root extracts and formulations.Aim of the study
To study the effect of standardized Asparagus racemosus root aqueous extract (ARE) on systemic Th1/Th2 immunity of SRBC sensitized animals.Materials and methods
We used HPTLC to quantify steroidal saponins (Shatavarin IV, Immunoside®) and flow cytometry to study effects of ARE on Th1/Th2 immunity. SRBC specific antibody titres and DTH responses were also monitored as markers of Th2 and Th1 responses, respectively. We also studied lymphocyte proliferation. Cyclosporin, cyclophosphamide and levamisole were used as controls.Results
Treatment with ARE (100 mg/(kg b.w. p.o.)) resulted in significant increase of CD3+ and CD4/CD8+ percentages suggesting its effect on T cell activation. ARE treated animals showed significant up-regulation of Th1 (IL-2, IFN-g) and Th2 (IL-4) cytokines suggesting its mixed Th1/Th2 adjuvant activity. Consistent to this, ARE also showed higher antibody titres and DTH responses. ARE, in combination with LPS, Con A or SRBC, produced a significant proliferation suggesting effect on activated lymphocytes.Conclusion
The study suggests mixed Th1/Th2 activity of ARE supports its immunoadjuvant potential. 相似文献103.
In primary visual cortex of hooded rats, pyramidal cells in layer V may be classified as long, medium, or short, on the basis of the layer in which the apical dendrite terminates. The present study determines which of these types of pyramidal cells project to the superior colliculus. Two different strategies were used to label corticotectal cells with horseradish peroxidase (HRP). In the first set of experiments, a large number of corticotectal cells were labeled by retrograde transport following injection of HRP into the superior colliculus. In the second set of experiments, single unit recording was used to identify corticotectal cells physiologically by antidromic activation from the superior colliculus. These cells were then impaled and labeled by intracellular iontophoresis of HRP. The results from both techniques suggest that only long pyramidal cells send an axon to the superior colliculus. These cells are distinguished by an apical dendrite that extends into layer I. We conclude that in hooded rats corticotectal cells in primary visual cortex are the long pyramids in layer V. 相似文献
104.
目的探讨复方丹参注射液联合干扰素治疗慢性乙肝患者的疗效。方法110例慢性乙肝患者,按随机方法分成①对照组30例,应用普通保肝药物治疗,疗程6个月;②丹参组30例,应用复方丹参注射液(每ml含丹参、降香各1g)30ml加入10%葡萄糖溶液300ml中静脉注射1个月;③IFN组30例,应用IFN—α 3MU,隔日一次肌内注射,3个月;④联合组20例,应用复方丹参注射液30ml加10%葡萄糖溶液300ml静脉注射1个月,IFN-α 3MU,隔日一次肌内注射,3个月。丹参组,IFN组和联合组保肝药物治疗同对照组。四组病例在性别、年龄、病程,治疗前肝功能等方面均无统计学差异。治疗前检测肝功能,肝炎病毒标志,血清HA、IV—C、PCI—Ⅱ,部分病例进行肝穿病理检查。治疗开始后每月检测肝功能,3个月(治疗后)和6个月(随访时)时检测血清HA、IV—C、PCⅢ及乙肝病毒标志,治疗后1年行肝穿病理检查。结果治疗前四组患者血清HA、PCⅢ、IV—C水平无统计学差异;治疗后丹参组、IFN组、联合组血清HA、FCⅢ、IV—C水平较治疗前及对照组有不同程度的降低。结论复方丹参注射液联合IFN治疗可使血清HA、PCⅢ、IV—C有明显下降,肝组织病理改变明显改善,为目前有效的慢性乙肝治疗措施。 相似文献
105.
Abstract: Native chemical ligation has proven to be a powerful method for the synthesis of small proteins and the semisynthesis of larger ones. The essential synthetic intermediates, which are C‐terminal peptide thioesters, cannot survive the repetitive piperidine deprotection steps of Nα‐9‐fluorenylmethoxycarbonyl (Fmoc) chemistry. Therefore, peptide scientists who prefer to not use Nα‐t‐butyloxycarbonyl (Boc) chemistry need to adopt more esoteric strategies and tactics in order to integrate ligation approaches with Fmoc chemistry. In the present work, side‐chain and backbone anchoring strategies have been used to prepare the required suitably (partially) protected and/or activated peptide intermediates spanning the length of bovine pancreatic trypsin inhibitor (BPTI). Three separate strategies for managing the critical N‐terminal cysteine residue have been developed: (i) incorporation of Nα‐9‐fluorenylmethoxycarbonyl‐S‐(N‐methyl‐N‐phenylcarbamoyl)sulfenylcysteine [Fmoc‐Cys(Snm)‐OH], allowing creation of an otherwise fully protected resin‐bound intermediate with N‐terminal free Cys; (ii) incorporation of Nα‐9‐fluorenylmethoxycarbonyl‐S‐triphenylmethylcysteine [Fmoc‐Cys(Trt)‐OH], generating a stable Fmoc‐Cys(H)‐peptide upon acidolytic cleavage; and (iii) incorporation of Nα‐t‐butyloxycarbonyl‐S‐fluorenylmethylcysteine [Boc‐Cys(Fm)‐OH], generating a stable H‐Cys(Fm)‐peptide upon cleavage. In separate stages of these strategies, thioesters are established at the C‐termini by selective deprotection and coupling steps carried out while peptides remain bound to the supports. Pilot native chemical ligations were pursued directly on‐resin, as well as in solution after cleavage/purification. 相似文献
106.
中药注射剂治疗心脑血管系统疾病用药分析 总被引:4,自引:0,他引:4
中药注射剂是指在中医理论指导下,采用现代科学技术与方法,从中药、天然药物的单方或复方中提取有效物质制成的可供注入人体灭菌制剂,包括肌肉、穴位、皮内、皮下、静脉注射以及其他组织或器官注射用的灭菌制剂以及供临床前配制溶液的无菌粉末或浓缩液。主要有中药溶液型注射剂(含水针和静脉注射剂)、注射用粉针和冻干制品、注射用混悬剂和注射用乳剂。目前,中药注射剂品种的研发主要集中在治疗心脑血管、呼吸系统和肿瘤等疾病上,显示出其独特的优势。本文对用于治疗心脑血管系统疾病的中药注射剂进行分析和探讨。 相似文献
107.
葛根素注射剂不良反应流行病学特点研究 总被引:2,自引:0,他引:2
目的 探讨葛根素注射剂不良反应的流行病学特点.方法 通过检索1978~2008年医药学期刊,收集葛根素注射剂不良反应详细病案120例;在构建数据库的基础上,应用统计学方法对其相关信息进行分析.结果 葛根素注射剂不良反应类型多样,其中以溶血反应数量最多,共32例,构成比为21.33%;其余依次为皮肤损害31例(20.67%),循环系统损害24例(16%),呼吸系统损害19例(12.67%),消化系统损害17例(11.33%),药物热11例(7.33%)和过敏性休克9例(6.00%)等.结论 溶血反应是葛根素注射剂最常见的不良反应;超剂量、不合理配伍、过敏性体质等可能是葛根素注射剂不良反应发生的主要原因. 相似文献
108.
Ulrik Sartipy Anders Albåge Per Insulander Dan Lindblom 《Journal of interventional cardiac electrophysiology》2007,19(3):171-178
This article presents a review on the efficacy of surgical ventricular restoration and direct surgery for ventricular tachycardia
in patients with left ventricular aneurysm or dilated ischemic cardiomyopathy. The procedure includes a non-electrophysiologically
guided subtotal endocardiectomy and cryoablation in addition to endoventricular patch plasty of the left ventricle. Coronary
artery bypass surgery and mitral valve repair are performed concomitantly as needed. In our experience, this procedure yielded
a 90% success rate in terms of freedom from spontaneous ventricular tachycardia, with an early mortality rate of 3.8%. A practical
guide to the pre- and postoperative management of these patients is provided.
Electronic supplementary material The online version of this article (doi: ) contains supplementary material, which is available to authorized users. 相似文献
109.
110.
鱼腥草注射液佐治下呼吸道感染的疗效观察 总被引:1,自引:0,他引:1
目的观察鱼腥草注射液佐治下呼吸道感染的疗效及安全性.方法将76例急性下呼吸道感染患者随机分为治疗组和对照组,两组均予内科常规治疗,治疗组则另予鱼腥草注射液治疗.结果治疗组的总有效率为94.7%,显著优于对照组的73.7%(x2=6.33,P<0.05),且未见明显副作用.结论鱼腥草注射液佐治急性下呼吸道感染安全、有效,值得推广. 相似文献