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51.
Chun Chang John Lipian Dennis A. Barnes Larry Seger Cheryl Burns Brian Bennett Laura Bonney Larry F. Rhodes George M. Benedikt Robert Lattimer Shyhchang S. Huang Victor W. Day 《Macromolecular chemistry and physics.》2005,206(19):1988-2000
Summary: Homopolymers of a bis‐trifluorocarbinol substituted norbornene ( 1 ) (α,α‐bis(trifluoromethyl)bicyclo[2.2.1]hept‐5‐ene‐2‐ethanol or HFANB) and copolymers of 1 with t‐butyl ester of 5‐carboxylic acid ( 2 , t‐BuEsNB) were produced using palladium catalysts and olefinic chain transfer agents such as 1‐hexene and ethylene to control molecular weight. However, these low‐molecular‐weight polymers exhibited relatively low optical transparencies at 193 nm. In fact, the opacity (measured as optical densities in absorbance units per micron) of thin films of these homo‐ and co‐polymers was inversely proportional to their molecular weight. This relationship is consistent with an end group contribution to the film opacity. Spectroscopic analysis of these polymers by 1H NMR and MALDI‐TOF MS confirmed that 1‐hexene and ethylene chain transfer agents generated olefin‐terminated vinyl addition polymers. The olefinic end group contribution to optical density can be eliminated by appropriate chemical modification. Both epoxidation and hydrogenation of the polymer olefinic end groups generated very low optical density materials, independent of molecular weight, that are suitable as 193‐nm photoresist binder resins.
52.
Regiane R. Santos Ajay Awati Petra J. Roubos-van den Hil Theo A. T. G. van Kempen Monique H. G. Tersteeg-Zijderveld Peter A. Koolmees 《Avian pathology》2019,48(6):582-601
ABSTRACTWe evaluated a blend of medium-chain fatty acids (MCFA), organic acids, and a polyphenol antioxidant on gut integrity. Eighty Ross Broilers were exposed to 20–22°C (control – normothermic) or to 35–39.5°C (heat stress) for eight hours a day for a period of 1 or 5 days. Birds were fed a standard diet, or a diet supplemented with the test blend. Thereafter, birds were euthanized, and intestinal sections were excised for morphological, morphometric and gene expression analyses. Blood samples were collected for glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GSH-Px) activity and trolox equivalent antioxidant capacity (TEAC) determination. Heart and liver tissues were used to quantify the expression of heat shock proteins 60 and 70 (HSP60 and HSP70, respectively) and inhibitor of kappa light chain gene enhancer in B cells alpha (IKBA). The jejunum was the most sensitive intestinal section, where heat stress modulated the expression of HSP70, of the inflammatory markers IKBA, interleukin 8 (IL-8), interferon gamma (IFNγ), and toll-like receptor 4 (TLR4). Moreover, expression of tight junctions (CLDN1, ZO1 and ZO2) and nutrient transporters (PEPT1 and EAAT3) was modulated especially in the jejunum. In conclusion, the feed additive blend protected intestines during heat stress from the decrease in villus height and crypt depth, and from the increase in villus width. Especially in the jejunum, heat stress played an important role by modulating oxidative stress and inflammation, impairing gut integrity and nutrient transport, and such deleterious effects were alleviated by the feed additive blend.RESEARCH HIGHLIGHTS
Jejunum is the most sensitive intestinal segment during heat stress.
Heat stress affects the expression of tight junctions and nutrient transporters.
Feed management helps to alleviate the disturbances caused by heat stress.
A blend of MCFA, organic acids and a polyphenol protects broilers under heat stress.
53.
Anne‐Marie Lamhonwah Simon E. Olpin Rodney J. Pollitt Christine Vianey‐Saban Priscille Divry Nathalie Guffon Guy T. N. Besley Russell Onizuka Linda J. De Meirleir Ljerka Cvitanovic‐Sojat Ivo Baric Carlo Dionisi‐Vici Ksenija Fumic Miljenka Maradin Ingrid Tein 《American journal of medical genetics. Part A》2002,111(3):271-284
Primary systemic carnitine deficiency or carnitine uptake defect (OMIM 212140) is a potentially lethal, autosomal recessive disorder characterized by progressive infantile‐onset cardiomyopathy, weakness, and recurrent hypoglycemic hypoketotic encephalopathy, which is highly responsive to L ‐carnitine therapy. Molecular analysis of the SLC22A5 (OCTN2) gene, encoding the high‐affinity carnitine transporter, was done in 11 affected individuals by direct nucleotide sequencing of polymerase chain reaction products from all 10 exons. Carnitine uptake (at Km of 5 μM) in cultured skin fibroblasts ranged from 1% to 20% of normal controls. Eleven mutations (delF23, N32S, and one 11‐bp duplication in exon 1; R169W in exon 3; a donor splice mutation [IVS3+1 G > A] in intron 3; frameshift mutations in exons 5 and 6; Y401X in exon 7; T440M, T468R and S470F in exon 8) are described. There was no correlation between residual uptake and severity of clinical presentation, suggesting that the wide phenotypic variability is likely related to exogenous stressors exacerbating carnitine deficiency. Most importantly, strict compliance with carnitine from birth appears to prevent the phenotype. © 2002 Wiley‐Liss, Inc. 相似文献
54.
V. A. Struchkov N. B. Strazhevskaya D. Yu. Blokhin 《Bulletin of experimental biology and medicine》1992,113(5):716-719
All-Russian Oncologic Scientific Center, Academy of Medical Sciences, Moscow. (Presented by Academician of the Academy of Medical Sciences N. N. Trapeznikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 5, pp. 529–531, May, 1992. 相似文献
55.
Exposure in swine confinement buildings induces an intense airway inflammation. Twenty-two volunteers, of whom eleven wore
a half-mask, were exposed for 3 hr in a swine barn. Blood samples were drawn before and after exposure. The ratio C3b/totalC3
in plasma decreased from 6.8 to 5.0% (p = 0.02) without mask and from 6.6 to 5.9% (p = 0.01) with mask (p = 0.67 between groups). The ratio Bb/totalB decreased from 14.5 to 13.5% (p < 0.01) without and 14.6–13.3% (p = 0.09) with mask (p = 0.25 between groups). Epithelial cells (A549) incubated up to 24 hr with 0.1 mg/mL dust suspensions were analysed for C3,
IL-6 and IL-8 secretion. Cumulative C3 synthesis of dust stimulated cell cultures was 43,000 pg/mL compared to 25,000 pg/mL
in unstimulated cells. Cumulative dust-induced IL-6 and IL-8 secretion was 200 and 3000 pg/mL, respectively and below detection
in unstimulated cells.The activation of complement in vivo and induced C3 synthesis by epithelial cells suggests a role of complement in the airway reaction to organic dust exposure. 相似文献
56.
Vilarinho L Cardoso ML Gaspar P Barbot C Azevedo L Diogo L Santos M Carrilho I Fineza I Kok F Chorão R Alegria P Martins E Teixeira J Cabral Fernandes H Verhoeven NM Salomons GS Santorelli FM Cabral P Amorim A Jakobs C 《Human mutation》2005,26(4):395-396
We studied 21 patients, from 18 families, with L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic disorder with a homogeneous presentation: progressive neurodegeneration with extrapyramidal and cerebellar signs, seizures, and subcortical leukoencephalopathy. Increased levels of L-2-hydroxyglutaric acid in body fluids proved the diagnosis of L-2-HGA in all 21 patients. We analyzed the L-2-HGA gene (L2HGDH), recently found to be mutated in consanguineous families with L-2-HGA, and identified seven novel mutations in 15 families. Three mutations appeared to be particularly prevalent in this Portuguese panel: a frameshift mutation (c.529delC) was detected in 12 out of 30 mutant alleles (40%), a nonsense mutation (c.208C>T; p.Arg70X) in 7/30 alleles (23%), and a missense mutation (c.293A>G; p.His98Arg) in four out of 30 mutant alleles (13%), suggesting that common origin may exist. Furthermore, two novel missense (c.169G>A; p.Gly57Arg, c.1301A>C; p.His434Pro) and two splice error (c.257-2A>G, c.907-2A>G) mutations were found. All the mutations presumably lead to loss-of-function with no relationship between clinical signs, progression of the disease, levels of L-2-HGA and site of the mutation. In the three remaining families, no pathogenic mutations in the L-2-HGA were found, which suggests either alterations in regulatory regions of the gene or of its intervening sequences, compound heterozygosity for large genomic deletion and, or further genetic heterogeneity. 相似文献
57.
J. Mertens J. Eersels W. Vanryckeghem 《European journal of nuclear medicine and molecular imaging》1987,13(3):159-160
A new high yield 123I radioiodination (97%), based on the Cu(I) assisted isotopic exchange in an ethanol water mixture, of 15(p-I-phenyl)-9 methyl pentadecanoic acid, a potential myocardial tracer, is proposed. The method allows a true kit preparation of radioiodinated phenyl fatty acids for a substrate concentration of ±10-6 moles. High specific activities (>0.1 mCi/g) can be obtained when coupling the labelling method to HPLC purification with an overall radiochemical yield of 75%. 相似文献
58.
李霄 《中国医疗器械信息》2021,(1)
目的:对原发性肝癌患者介入术后接受CT、MRI诊断病灶残留及复发的临床价值进行系统研究与探讨。方法:选择本院2018年12月~2019年12月收治的90例行介入术原发性肝癌患者作为实验对象,数字奇偶法分组后探究每组诊断效果。对照组(45例)应用CT诊断;观察组(45例)应用MRI诊断。对比两组患者残留及复发病灶数量。结果:观察组残留及复发病灶数量为(66.44±3.75)个,较之于对照组,差异具有统计学研究意义(P<0.05)。结论:原发性肝癌患者接受介入手术治疗后,在诊断病灶残留与复发中,MRI诊断优势更明显。 相似文献
59.
利用电池电动势法测定了298.15K下NaCl在不同DMF含量的水-DMF混合溶剂中的活度系数。结果表明,随着混合溶剂中DMF含量的增加NaCl的活度系数减小,测定了水-DMF-NaCl混合物在不同温度下的粘度。 相似文献
60.
以聚4-甲基戊烯-1(PMP)为膜材质、分别以环己烷、三氯乙烯以及环己烷/三氯乙烯为溶剂,以浇铸法制备了PMP的均质致密膜。研究了不同溶剂体系的相对溶解能力和挥发速度对PMP膜结晶度和形态结构的影响,并对成膜的渗透汽化特性的影响进行了研究。 相似文献