The effect of acute zimeldine and alaproclate administration on the acquisition of two-way active avoidance: Comparison with other antidepressant agents,test of selectivity and sub-chronic studies

The dose-dependent effect of acute zimeldine and alaproclate treatment upon the acquisition of two-way and one-way active avoidance in the rat was studied in a single-session and in a repeated-sessions design. Zimeldine (5–20 mg/kg, IP), but not alaproclate, caused disruptions of two-way avoidance acquisition. Acquisition deficits were also caused by citalopram and fluoxetine but not the other antidepressant drugs tested. Zimeldine, but not alaproclate or desipramine, caused a slight but non-significant impairment of one-way active avoidance; neither zimeldine nor alaproclate produced any effects upon fear conditioning and retention testing. The long-term action of p-chloroamphetamine (2×10 mg/kg) antagonised the acute zimeldine effect totally, and chronic treatment with zimeldine (15 days, 1×50 mol/kg) and chlorimipramine (15 days, 2×10 mol/kg) also caused some partial blockade of the two-way avoidance deficit. These data seem to suggest some involvement of serotonin (5-HT) in the observed disruptions of two-way active avoidance caused by acute zimeldine treatment.     

DRGs视角下某医院医疗服务半径分析

目的通过分析某三甲医院的医疗服务半径及其变化趋势,为医院的科学发展规划提供决策依据。方法获取2016年至2019年的病案首页资料和DRGs运行指标,按患者现住址的行政区域统计分析各项业务指标的变化情况。结果医院各区域出院人次和DRGs组数均逐年增长,市本级患者构成比呈逐年下降趋势(χ趋势^2=441.74,P<0.001);区域CMI值表现为外市患者高于外县市高于市本级;MDCY(烧伤)、MDCN(女性生殖系统疾病及功能障碍)、MDCQ(血液、造血器官及免疫器官疾病和功能障碍)等MDC和整形烧伤科、神经外科、心胸外科等临床学科的区域辐射能力在增强。结论该院医疗服务辐射范围整体上有逐年扩张的趋势,未来需通过持续提升医疗质量和效率,积极推行分级诊疗,加强学科建设等措施,为本地市及周边区域的患者提供更加高质高效的医疗服务。     

视神经萎缩的治疗临床研究

目的 探讨视神经萎缩的有效治疗方法。方法 对324例526例眼视神经萎缩患,用胞二磷胆碱、肌苷做球后注射。结果 临床治愈88例,显效261例,进步106眼,有效率86．9％,收到了较满意的效果。结论 胞二磷胆碱、肌苷可通过卵磷脂的合成改善视神经周围的血液循环,刺激和促进视神经纤维的生物修补,从而导致视神经功能的改善和恢复。     

高频电汽化切除并注射THP治疗浅表膀胱癌18例

目的：探讨高频电汽化切除后粘膜下注射及膀胱内灌注抗癌药物治疗浅表膀胱肿瘤的效果。方法：经尿道高频电汽化膀胱肿瘤、肿瘤周围粘膜下和基底部注射盐酸吡柔比星（THP）,术后间断膀胱内灌注THP。结果：本组18例浅表膀胱肿瘤,术中、术后均无输血,无膀胱穿孔,未引起组织坏死。术后随访（6－15）月,未引起骨髓抑制,未见肿瘤复发。结论：此方法操作简单、安全、恢复快,并发症低。粘膜下注射并膀胱内灌注抗癌药物重点部位突出,药液扩散均匀,既可杀灭存留的肿瘤细胞,又对微小癌灶产生毒性作用,对治疗和预防浅表肿瘤复发疗效可靠。     

高校校长办公室工作的思考

院长办公室是学校的重要窗口 ,它的服务态度、工作质量和效率直接影响到学校的形象。校长办公室应不断加强自身建设 ,充分发挥参谋和助手作用 ,着力强化协调综合功能 ,脚踏实地开展督促检查 ,使办公室在沟通上下、协调左右、联系内外的过程中 ,不断提高工作质量 ,提升服务水平 ,真正成为校领导指挥全局、运筹决策的参谋部。     

Efecto sobre el comportamiento de dexmedetomidina como premedicación anestésica en la población pediátrica: Estudio prospectivo observacional

Premedication in the pediatric population is of vital importance to reduce anxiety and facilitate anesthetic induction. Midazolam and ketamine have been used for this purpose, drugs that have shown long-term changes in neurodevelopment. Dexmedetomidine promotes a sedative, analgesic effect and lacks neurotoxic effects, its intranasal application is easy and minimally invasive. We studied the sedative and behavioral effect of intranasal dexmedetomidine 2 mcg/kg in ASA 1 and 2 children for elective surgery. They were evaluated at 10, 20 and 30 minutes of administered, in the separation of the parents and placement of the mask for inhalation induction with behavioral and sedation scores (classified from 1 to 4), we considered acceptable for admission to operating room categories 3 and 4.ResultsThirty patients between 1 and 10 years old were included in the period from September 2017 to April 2018. The sedation score obtained at 30 minutes was acceptable in 46.6% of the patients and the behavior score was in 96% of the cases. In 63% of cases the acceptance of the facial mask placement for inhalation induction was achieved. The procedure was well tolerated in all cases and parents were satisfied in 100% of the cases.     

Successful navigation of late career transitions

The purpose of this educational review was to describe the challenges that may face the anesthesiologist near the end of their career and to propose strategies that will enable the individual to continue to be a productive and valued member of their Department, both clinically and by other contributions.     

Immediate rehabilitation of a rheumatoid arthritis patient with single-piece implants

Introduction and importanceThe aim of this article is to report the long-term outcome of full mouth rehabilitation with single piece, smooth surface implants following immediate loading protocol on a patient suffering with RA and severe unilateral condylar resorption.Case presentationHere, we present a challenging case of a patient suffering from Rheumatoid Arthritis who was stabilized and completed successfully with a 4 year follow-up period. Prosthetic management optimized the inter-occlusal relationship to maintain both function and esthetic integrity. Single piece implants are designed to engage and take support from the cortical bone low in metabolic activities thus promoting the force transmission through apical threads that are engaged in the cortical bone.DiscussionRheumatoid Arthritis [RA] is an auto-immune inflammatory condition in which the inflamed and hypertrophic synovial membrane grows into the articulation surfaces. The Temporomandibular Joints [TM] are frequently involved in rheumatoid arthritis. According to the literature on RA, due to frequent periodontitis, decreased salivary secretion, medication, as well as decrease in bone regenerative potential, RA is often considered as a relative contraindication in the use of implants. Atrophic jaws and cases with comorbidities like osteoporosis, diabetes, rheumatoid arthritis, periodontally infected cases are restored with high success by single piece smooth surface.ConclusionTo the best of our knowledge, this may be the first case of immediate functional loading by bi-cortical single piece implants.