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41.
男性青少年性腺功能减退症患者短期雄激素替代治疗对血脂和hsCRP水平的影响 总被引:1,自引:0,他引:1
目的 探讨性腺功能低减的青少年男性,短期雄激素替代治疗对血脂和超敏C反应蛋白(hsCRP)的影响。方法 本研究为前瞻性自身对照研究,共纳入33例性腺功能减退青少年男性。行短期(9个月)雄激素替代治疗,比较治疗前后血睾酮水平、第二性征发育程度、身高、握力、血红蛋白、血脂和hsCRP的差异。结果 (1)替代治疗后,睾酮水平明显升高,第二性征明显发育,身高、握力、血红蛋白显著增加(P值均〈0.05);(2)短期雄激素替代治疗后,总胆固醇(TC),低密度脂蛋白(LDL-c),高密度脂蛋白(HDL-c)和甘油三酯(TG)部有所下降,但无统计学差异(P〉0.5)。超敏CRP显著下降(P=0.025)。结论 (1)性腺功能低减的青少年男性,短期雄激素替代治疗,可以促进第二性征发育,增加身高、握力和血红蛋白;(2)短期雄激素替代治疗,对血脂无显著性影响。但是,可以使hsCRP明显下降。 相似文献
42.
Dongsoon Shin 《Nutrition Research And Practice》2009,3(1):31-37
Recently, Korean people are consuming seaweeds almost 3.5 times more now than three decades ago. It is well known that seaweeds contain lots of soluble dietary fiber in addition to micronutrients such as β-carotene, iodine and some bioactive components. Seaweeds are considered to be effective for preventing chronic diseases including obesity, diabetes mellitus, atherosclerosis, cancer or constipation. This study was conducted to investigate the effect of seamustard intake on body weight gain, blood glucose level and lipid profiles in rats fed diets with different energy nutrient composition. Male Sprague-Dawley rats (average initial weight 103.7 g) were divided into groups for two experiments as follows; Control, M2.5 & M5 groups (Exp. I) and M5, M10, HCM5, HCM10, HFM5 & HFM10 groups (Exp. II). The rats were fed diet and water ad libitum for 4 weeks. In general, there was no significant difference in blood glucose and triglyceride concentration among groups. In Exp. I, serum LDL-cholesterol level of rats fed diet with 5% seamustard powder (M5) was significantly lower than that of control group, while HDL-cholesterol level, TC/LDL ratio and weight of adrenal gland were higher. In Exp. II, food intake, body weight gain and EER of high fat diet with 10% seamustard group (HFM10) were the lowest among groups. Except gastrocnemius muscle, all organ weights of HFM10 group were the lowest. Fecal cholesterol excretion and serum LDL-cholesterol concentration of HFM10 group were the highest, while serum HDL-cholesterol level was the lowest among groups. Interestingly, HDL-cholesterol concentration was the highest in HCM5 group among groups. From these results, it was suggested that seamustard intake might be more effective for body weight control, but not for improving blood lipid profiles in high fat diet than in high carbohydrate diet. 相似文献
43.
Improvement of endoneurial lipid abnormalities in experimental diabetic neuropathy by oxygen modification 总被引:1,自引:0,他引:1
Endoneurial hypoxia and a high frequency of closed capillaries have been found in chronic experimental diabetes and human diabetic sural nerve, respectively. These findings have led to the hypothesis that the pathogenesis of diabetic neuropathy is due to endoneurial hypoxia. To evaluate the role of endoneurial hypoxia in experimental diabetic neuropathy, the effects of supplementation and deprivation of oxygen on peripheral nerve lipid biosynthesis were studied in normal control and streptozotocin-induced diabetic rats. Defective lipid biosynthesis in diabetic nerve was partially prevented by oxygen supplementation. When normal rats were placed in a hypoxic chamber, lipid abnormalities similar to those observed in diabetic nerves were demonstrated in the absence of changes in nerve free sugars. These findings suggest that endoneurial hypoxia may underlie some key biochemical abnormalities encountered in experimental diabetic neuropathy. 相似文献
44.
T. A. Goncharova K. N. Kontorshchikova 《Bulletin of experimental biology and medicine》1998,126(2):826-828
Injection of ozonized normal saline to animals with transplanted sarcoma-45 normalized energy metabolism in the liver, which
is important for this organ's function under conditions of malignant growth.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 8, pp. 207–209, August, 1998 相似文献
45.
G. I. Bisharova L. I. Kolesnikova V. V. Malyshev 《Bulletin of experimental biology and medicine》1998,126(3):947-949
A comparative study of the parameters of free-radical lipid peroxidation and antioxidant system was performed in children
living in the North for various time periods. Intense lipid peroxidation was shown to be the key factor in the pathogeneses
of several diseases caused by disturbances in the cellular membrane. Decreased resistance of red blood cells to peroxidative
hemolysis is a phenomenon characterizing the adaptation-violating processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 9, pp. 342–344, September, 1998 相似文献
46.
依据乡村医生人力结构现状调查结果,就现阶段县级卫校在初级卫生保健中的作用及今后面向乡村医生办学的可行性作了具体的分析和探讨。结论是:提高质量,加强对在岗乡医进行系统化正规中专层次的职后复训,应是县级卫校今后1O年的最主要的任务。 相似文献
47.
Jim-Shoung Lai T.-N. Wu Saou-Hsing Liou Chen-Yang Shen Chiam-Fang Guu Kquei-Nu Ko Chi. Hsueh-Yun P.-Y. Chang 《International archives of occupational and environmental health》1997,69(4):295-300
Objective: To examine the relationship between ambient lead levels and blood lead levels and to explore the modifiers of the relationship
between ambient lead and blood lead. Method: A cross-sectional study was conducted in two lead battery factories. Blood lead level and ambient lead concentration were
measured for each participant concurrently. A structured questionnaire was administered to collect sociodemographic characteristics
and occupational history. Design: Biological and personal environmental measurements of 219 lead-exposed workers were analyzed by both simple and multiple linear
regression. A regression model was selected for interpretation. Results: A high correlation (r=0.62) between ambient lead (PbA) and blood lead (PbB) was observed. In addition, numerous factors, including age, sex, alcohol
consumption, personal hygiene practice and type of lead exposure, were also found to influence blood lead levels. Although
PbB was highly correlated with PbA, blood lead level may not be effectively lowered by reducing ambient lead level. Based
on the regression coefficients, improvement of hygienic practice was more effective at lowering PbB than reducing ambient
lead level. Good hygienic practice may be the preferential way to reduce lead exposure in current conditions. Conclusion: Education of correct work practice may be more important than engineering control in the developing countries to lower blood
lead levels in lead battery factories.
Received: 28 May 1996/Accepted: 30 August 1996 相似文献
48.
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50.
重组血管内皮细胞生长因子在大肠杆菌的高效表达 总被引:3,自引:0,他引:3
目的:使重组血管内皮细胞生长因子(VEGF)在大肠杆菌中得到高效表达.方法:通过构建表达重组VEGF的质粒PRL621/VEGF,并在大肠杆菌中高效表达.结果:表达量约占菌体总蛋白的40%.对形成包含体的表达产物进行变性,初步复性处理,得到重组人VEGF粗提液,鸡胚绒毛尿囊膜试验表明有促血管生长活性,N-端15个氨基酸序列分析结果,与天然VEGF蛋白质相应序列一致. 相似文献