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101.
差异显示法的建立及其在辐射致癌机理研究中的初步应用 总被引:1,自引:0,他引:1
本研究目的建立差异显示技术,将基应用于辐诱发肺癌发生相关基因研究中。聚SHTF细胞(SV40永生化人胎气管成纤维细胞)和αSHTF细胞(α粒子照射后能在软琼脂上形成克隆的SHTF细胞)以及肺癌组织和同例正常肺组织为模板,将其mRNA进行RTPCR扩增,采用放射自显影法和硝酸银染色法显示扩增片段,并比较两者的显示效果。结果表明:在细胞和组织样品中均建立了差异显示法,但硝酸银染色的条带较放射自显影显示 相似文献
102.
合成的阿魏硝胺(乙醇胺硝酸酯的阿魏酸盐),具有明显的心血管效应,可使麻醉兔降低全身血压39±12mmHg,但对心电图无明显影响(iv)。它对抗垂体后叶素所致急性心肌缺血(iv),能增强小鼠耐缺氧能力(ip),并能增加麻醉狗的冠脉血流量(iv);并能明显抑制去甲肾上腺素(NE)引起的动脉血管条收缩。本品对小鼠的 LD_(50)为857mg/kg(iv),>1200mg/kg(PO)。 相似文献
103.
将周围静脉压测定法稍加改良后用于监测硝酸酯静脉扩张效应60例次,结果舌下含服硝酸甘油(NTG)后1~2min静脉压开始下降,4~6min显下降,9-12min下降到最大值,平均下降比率53.61±7.83%。认为周围静脉压测定法监测NTG扩血管效应方法简单,操作方便,过程稳定,数据可靠。 相似文献
104.
Bang-qiao Yin Yu-hong Guo Yuan Liu Yang-yang Zhao Shan-mei Huang Xia-wei Wei Heng-sheng Wang Ruo-ya Liu Ying Liu Yao-ping Tang 《中草药(英文版)》2021,13(3):396-402
ObjectiveMost of the studies on the herb Chuanxiong Rhizoma (CR) have focused on the l-arginine-nitric oxide (NO) pathway, but the nitrate-nitrite-NO (NO3−–NO2−–NO) pathway was rarely investigated. Therefore, the aim of this study was to evaluate the effects and mechanisms of action of CR in coronary artery disease (CAD).MethodsThe NO3−, NO2− and NO levels were examined in the NO3−–NO2−–NO pathway. High-performance ion chromatography was used to quantify NO3− and NO2− levels. Then, NO was quantified using a multifunctional enzyme marker with a fluorescent probe. The tension of aortic rings was measured using a multi myograph system.ResultsHigh content of NO3− and low content of NO2− was found in CR, and which could potently convert NO3− to NO2− in the presence of endogenous reductase enzyme. Incubating human coronary artery endothelial cells (HCAECs) with CR-containing serum showed that CR significantly decreased the NO3− content and increased the levels of NO2− and NO in the cells under hypoxic conditions. In addition, CR significantly relaxed isolated aortic rings when the l-arginine –NO pathway was blocked. The optimal concentration of CR for relaxation was 200 mg/mL.ConclusionCR supplements large amounts of NO in cells and vessels to achieve relaxation via the NO3−–NO2−–NO pathway, thereby making up for the deficiency caused by the lack of NO after the l-arginine-NO pathway is suppressed. This study also supports the potential use of a traditional Chinese herb for future drug development. 相似文献
105.
Nitric oxide (NO) importantly contributes to cardiovascular homeostasis by regulating blood flow and maintaining endothelial integrity. Conversely, reduced NO bioavailability is a central feature during natural ageing and in many cardiovascular disorders, including hypertension. The inorganic anions nitrate and nitrite are endogenously formed after oxidation of NO synthase (NOS)‐derived NO and are also present in our daily diet. Knowledge accumulated over the past two decades has demonstrated that these anions can be recycled back to NO and other bioactive nitrogen oxides via serial reductions that involve oral commensal bacteria and various enzymatic systems. Intake of inorganic nitrate, which is predominantly found in green leafy vegetables and beets, has a variety of favourable cardiovascular effects. As hypertension is a major risk factor of morbidity and mortality worldwide, much attention has been paid to the blood pressure reducing effect of inorganic nitrate. Here, we describe how dietary nitrate, via stimulation of the nitrate‐nitrite‐NO pathway, affects various organ systems and discuss underlying mechanisms that may contribute to the observed blood pressure‐lowering effect. 相似文献
106.
107.
茶多酚对硝酸羟胺染毒小鼠血常规和血清生化值的影响 总被引:3,自引:1,他引:3
目的 观察绿茶提取物茶多酚对硝酸羟胺染毒小鼠血常规、血清生化值的影响。方法 采用腹腔注射硝酸羟胺建立中毒模型。雄性ICR小鼠随机分为正常组、硝酸羟胺染毒组、茶多酚预防组、茶多酚治疗组 ,常规测量各组外周血细胞和生化指标。结果 经过统计学分析 ,茶多酚可明显促进硝酸羟胺中毒导致的小鼠血常规的WBC、RBC、HGB、PLT计数改变的恢复 ,部分血清生化值AST/ALT、ChE、ALB、LDH、UA、Fe病理性改变的恢复。结论 茶多酚灌胃给药对硝酸羟胺中毒引起的氧化损伤具有一定的保护作用 相似文献
108.
How to use nitrates 总被引:2,自引:0,他引:2
Abrams J 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2002,16(6):511-514
Nitrates are old drugs, available in many formulations, that are effective in relieving symptoms in various CAD syndromes as well as congestive heart failure. Nitrate tolerance is the major problem limiting nitrate efficacy and use by physicians. Currently, an intermittent dosing strategy is the only practical way to limit the development of tolerance or attenuation of nitrate actions. 相似文献
109.
110.
[摘要]目的评价硝酸舍他康唑栓治疗外阴阴道假丝酵母菌病的疗效及安全性。方法采用随机双盲对照试验。治疗组及对照组各30例,分别外用硝酸舍他康唑栓300 mg和克霉唑栓500 mg,用药1或2次。停药后(7±1) d及28~35 d时进行观察。结果治疗组28例、对照组30例纳入分析,治疗组和对照组停药后(7±1) d临床有效率分别为89.29%,86.67%(P>0.05);用药结束后28~35 d时的临床有效率分别为81.48%,66.67%(P>0.05);均未发生与药物相关的不良反应。结论硝酸舍他康唑栓治疗外阴阴道假丝酵母菌病有效,安全。 相似文献