The potential of mild testicular heating as a safe, effective and reversible contraceptive method for men

A preliminary assessment of the contraceptive efficacy of a daily mild increase (1–2°c) in testicular temperature during waking hours is reported in nine couples using two techniques of non-surgical fixation of the testes close to the inguinal canal. With technique 1, immobilization was achieved by passing the penis and the empty scrotum through a hole made in close-fitting underwear; there was one pregnancy, hm a man who stopped the heating after 7 weeks, for 42 cycles of exposure in three couples. With technique 2, immobilization was achieved by adding a ring of soft material surrounding the hole in the underwear; there was no pregnancy for 117 cycles of exposure in six couples. Reversibility and safety were assessed. These preliminary results suggest that a daily mild increase in testicular temperature could be a potential contraceptive method for men.     

纳米抗菌剂抑菌杀菌性能研究

目的：检测纳米抗菌剂对标准菌株的杀菌、抑菌性能和高温对其抑菌效果的影响。方法：目标菌为大肠杆菌、金黄色葡萄球菌和白色念珠菌，通过悬液定量杀灭试验和抑菌环试验检测纳米抗菌剂的杀菌、抑菌能力。结果：水溶性纳米抗菌膜溶于5ml灭菌水中作用l0min可杀灭95．39％的金黄色葡萄球菌和93．28％的白色念珠菌，复合了纳米银的抗菌医用棉条、烧烫伤贴、创伤贴对大肠杆菌和金黄色葡萄球菌的抑菌环直径大于l0mm，对白色念珠菌的抑菌环直径大于7mm。结论：纳米抗菌剂对细菌繁殖体和白色念珠菌具有良好的抑菌、杀菌作用，高压灭菌处理对纳米银抗菌剂抑菌效果影响不大，但织物构造对其抑菌效果有影响。     

美宝湿润烧伤膏治疗急性肛裂疗效观察

目的：对美宝湿润烧伤膏(MEBO)、肛裂膏外用治疗急性肛裂进行疗效分析，判断其优劣。方法：将2000-2002年我院治疗的188例急性肛裂患者随机分为A组和B组，两组均采用相同的全身治疗，其中A组采用MEBO外用，B组采用肛裂膏外用。通过跟踪随访，在平均愈合时间、治愈率两方面进行判断分析，比较优劣。结果：A组在平均愈合时间、治愈率方面均优于B组。结论：湿润烧伤膏外用治疗急性肛裂优于肛裂膏，为治疗急性肛裂较好的外用药。     

优立新治疗急性细菌性感染的临床观察

优立新与头孢噻肟随机对照治疗呼吸道和泌尿道感染４０例，临床有效率各为１００％和９５％（Ｐ＞０．０５），细菌阴转率各为９４，１％和１００％（Ｐ＞０．０５）。无显著性差异。优立新共治疗３０例，临床有效率和细菌阴转率分别为１００％和９６％。两药副反应均轻微。无因副反应而停药。在优立新治疗病例中，有２例出现皮疹。另２例为肝功能ＡＬＴ和ＡＳＴ暂时性轻度增高。     

贯众提取液对革兰氏阳性球菌的抑菌作用

目的：了解贯众(Dryopteris crossirhizomz)不同提取液对革兰氏阳性球菌的抑菌作用。方法：分别用水以及3种不同pH值的70％乙醇为溶媒提取贯众干品以制备贯众提取液，利用打孔法和试管稀释法测定提取液对13种微生物的抑制效果。结果：每1ml含生药1g的贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用，尤其是革兰氏阳性球菌如金黄色葡萄球菌和甲型溶血性链球菌等。对革兰氏阴性菌和真菌的抑制作用较弱，但对普通变形杆菌则有较强的抑制作用。不同pH值的抽提溶剂对药物的有效抑菌成份的提出效果不同，抽提溶剂pH越小，有效成份的提出效果越好。结论：贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用，尤其是对革兰氏阳性球菌，而对革兰氏阴性菌和真菌的抑制作用则较弱。贯众的抗菌成份易溶于水，抽提效果随pH减小而增加。     

Ivermectin for the chemotherapy of bancroftian filariasis: a meta-analysis of the effect of single treatment

Summary The efficacy and safety of ivermectin in the treatment of filariasis due to Wuchereria bancrofti was assessed by a meta-analysis of the results from 15 published clinical trials. Seven hundred and forty-eight microfilaraemic patients were enrolled in 7 dose-finding and 8 comparative studies. Administered as a single dose, ivermectin induced nearly complete clearance of microfilariae from the blood from the first day to 30 days post-treatment, followed by gradual recurrence of microfilaraemia and increase in its intensity. Higher doses of ivermectin showed greater clearance effects and maintained lower microfilaraemia levels for a longer time. The adverse reactions caused by the drug were flu-like, transient, generally mild and well tolerated by patients. The frequency and intensity of adverse reactions were strongly associated with pretreatment microfilaria counts in the blood, but independent of dose. The findings of the meta-analysis suggest that ivermectin given at a single annual dose of 200 μg/kg body weight or higher, whether or not in combination with DEC, has great potential for therapeutic strategies to control bancroftian filariasis.     

经皮射频消融与手术切除治疗直径≤ 3 cm原发性小肝癌的疗效分析

目的 分析经皮射频消融（PRFA）与手术切除治疗直径≤3 cm原发性小肝癌的疗效。方法 选取2015年1月—2017年6月兰州市第二人民医院收治的原发性小肝癌患者78例。将36例接受PRFA治疗的患者作为观察组,另外42例行手术切除的患者作为对照组。采用全自动生化分析仪检测血清谷草转氨酶（AST）、谷丙转氨酶（ALT）、总胆红素（TBIL）水平,电化学发光全自动免疫分析仪检测血清甲胎蛋白（AFP）水平。结果 观察组手术时间、术中出血量、住院时间均少于对照组（P <0.05）;观察组治疗前后AST、ALT、TBIL、AFP的差值均高于对照组组（P <0.05）。两组术后并发症比较,差异无统计学意义（P>0.05）;两组治疗后1、2、3、5年的生存率和复发率比较,差异均无统计学意义（P>0.05）。结论 与手术切除比较,PRFA治疗直径≤3 cm原发性小肝癌可缩短手术时间,减少术中出血量,促进肝功能恢复,但两者术后并发症发生率、生存率和复发率接近。