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排序方式: 共有1607条查询结果,搜索用时 15 毫秒
41.
Abraham AM Kavitha S Joseph P George R Pillay D Malathi J Jesudason MV Sridharan G 《Indian journal of medical microbiology》2007,25(3):260-262
Resistance to aciclovir (ACV) among Herpes simplex virus (HSV) isolates is increasingly being reported in the literature particularly in immunocompromised patients. However, there is only limited data available from India despite widespread use of ACV in our hospital. A cross-sectional study was hence conducted to determine the aciclovir (ACV) susceptibility of HSV 1 and 2 isolates using a dye uptake (DU) assay. This study showed a 3.0% prevalence of ACV resistance among HSV-1 strains (2/66, median IC 50 0.098 microg/mL) while in HSV-2 strains, it was 7.8% (5/64, median IC 50 0.195 microg/mL). The IC 50 for the HSV-1 and HSV-2 strains resistant to ACV was greater than or equal to 6.25 microg/mL. 相似文献
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目的:通过检验和监管工作中发现的问题,对当前红花市场质量状况进行分析,为红花的质量监管及临床用药提供建议。方法:在全国范围内进行抽样检查,依据红花现行标准对抽验样品进行检验。统计分析检验数据及其存在的质量问题。结果:检验发现部分样品有染色现象。结论:染色的目的是掩盖药材的质量问题;非法加入的色素和染料,特别是一些化工合成染料的安全性风险较高,染色行为严重危害公众用药质量和安全。提升红花药材及饮片的质量,需要注重源头治理和可追溯体系建设,加强生产、流通、使用领域的监管,保障公众用药安全和有效。 相似文献
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Inan U Aydemir H Taşdemir T 《Australian endodontic journal : the journal of the Australian Society of Endodontology Inc》2007,33(1):18-22
The aim of this study was to compare the apical sealing ability of three different obturation techniques using an electrochemical evaluation and evaluating dye penetration. One hundred and thirty-two maxillary anterior teeth were randomly divided into six groups. There were 20 teeth in each group. The teeth were obturated as follows: Groups 1 and 4 with Thermafil, Groups 2 and 5 with System B, and Groups 3 and 6 with cold lateral condensation (CLC). The apical leakage in these groups was evaluated using an electrochemical method for Groups 1, 2, 3 and a dye penetration method for Groups 4, 5 and 6. In both methods, the lowest mean leakage values were observed for Thermafil and the highest were observed for the CLC groups. The difference between Thermafil and CLC was statistically significant (P < 0.05). In both groups, System B fillings showed moderate leakage and the difference was not significant with Thermafil and CLC groups. 相似文献
44.
目的 通过豚鼠离体回肠模型及小鼠类致敏实验评价注射用益气复脉(冻干,YQFM)的安全性。方法 建立豚鼠离体回肠模型,依次考察0.2、0.4、0.6、0.8、1.2、1.4、1.6 mg/mL质量浓度的YQFM对静息离体肠、乙酰胆碱(Ach)及组胺(His)诱导的离体肠收缩的抑制率;雄性ICR小鼠随机分为阴性对照组,阳性对照组(C48/80,25 mg/kg),YQFM低、高剂量(780、3 135 mg/kg,分别为临床等效剂量的0.85和3.43倍)组,分为尾iv含0.4%伊文思蓝(EB)的药液及不含0.4% EB的药液两部分进行体内类致敏反应实验,依次比较各组小鼠耳廓蓝染情况;ELISA法测定血清中His和5-羟色胺(5-HT)的含量;并对耳、肺组织进行HE染色及病理检查。结果 体外实验显示,YQFM既能够抑制离体肠的自主收缩,又能抑制Ach和His导致的离体肠痉挛;体内实验表明,YQFM低剂量组耳廓蓝染率,His、5-HT含量均在正常范围,组织病理检查未见明显异常;3.43倍临床等效剂量时耳廓蓝染率,His、5-HT含量略高,病理结果见轻微炎症反应。结论 YQFM的安全性基本良好,临床使用时需对使用剂量稍加注意,以防轻微不良反应发生。 相似文献
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《The Journal of foot and ankle surgery》2014,53(6):712-715
The purpose of the present investigation was to evaluate the distribution of intratendinous injected platelet-rich plasma (PRP) after 15 minutes of prone resting versus immediate manipulation simulating weightbearing. Ten cadaveric lower limbs were injected under ultrasound guidance with PRP dyed with India blue ink. The dyed PRP was injected into the mid-portion of the Achilles tendon, after which 5 specimens were placed in the prone position for 15 minutes (simulating rest) and the remaining 5 specimens were manipulated through 100 cycles of ankle dorsiflexion and plantarflexion (simulating walking). Thereafter, the specimens were dissected, and the distribution of the India blue dye was ascertained. In the simulated rest group, every specimen showed dyed PRP in the Achilles tendon and in the space between the paratenon and tendon. The median craniocaudal spread of the PRP was 140 (range 125 to 190) mm. In 4 of the simulated rest tendons (80%), the distribution of PRP extended across the entire transverse plane width of the tendon. In the simulated motion group, every specimen showed dyed PRP extending across the entire transverse plane width of the tendon and in the space between the paratenon and tendon. The median craniocaudal spread was 135 (range 115 to 117) mm. No statistically significant difference was found in the amount of craniocaudal spread between the simulated motion and rest groups. In conclusion, it does not appear to matter whether the ankle has been moved through its range of motion or maintained stationary during the first 15 minutes after PRP injection into the mid-portion of the Achilles tendon. The precise meaning of this information in the clinical realm remains to be discerned. 相似文献
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Porous carbon material with high specific surface area was prepared from soybean dreg by a simple and effective two-step method (high temperature pyrolysis and activation). The structural characteristics of the synthesized carbon were evaluated by Brunauer–Emmett–Teller (BET), N2 adsorption/desorption measurements/techniques, an elemental analyzer (EA), scanning electron microscopy equipped with energy dispersive X-ray spectroscopy (SEM-EDS), transmission electron microscopy (TEM), an X-ray diffractometer (XRD), Raman spectroscopy (Raman), a Fourier transform infrared spectrometer (FTIR), and X-ray photoelectron spectroscopy (XPS). The specific surface area of SDB-6-K was 2786 m2 g−1, the pore volume was 2.316 cm3 g−1, and the average pore size was 3.326 nm. The high specific surface area and effective functional groups of carbon material promoted the adsorption of methylene blue. The maximum adsorption capacity of SDB-6-K to methylene blue was 2636 mg g−1 at 318 K. The adsorption kinetic and isotherm data were most suitable for pseudo-second-order and Langmuir equations. The results showed that the adsorbent had excellent adsorptive ability and had good practical application potential in the field of dye wastewater treatment in the future. 相似文献